Results 61 to 70 of about 13,288 (170)

Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial K+ buffering in central white matter

open access: yesExperimental Physiology, Volume 111, Issue 3, Page 1313-1329, 1 March 2026.
Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley   +1 more source

Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells

open access: yesThe Journal of Physiology, Volume 604, Issue 5, Page 1820-1839, 1 March 2026.
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira   +7 more
wiley   +1 more source

Secretion from Islets and Single Islet Cells following Cryopreservation

open access: yesCell Transplantation, 1999
The ability to cryopreserve pancreatic islets has allowed the development of low-temperature banks that permit pooling of islets from multiple donors and allows time for sterility and viability testing.
Jonathan R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MS/MS

open access: yesBiochemistry Research International, 2018
Oldenlandia diffusa has been used to treat various cancers. Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine. Currently, the problem that remains is the effective treatment in drug-drug interaction situation.
Yiping Lin   +5 more
doaj   +1 more source

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

open access: yesDrug Design, Development and Therapy, 2020
Mei-ling Wu, Yi-ping Lin, Yan-li Wei, Hong-jian Du, Xiao-qian Ying, Wen-zhuang Tan, Bi-e Tang Faculty of Medicine, Jinhua Polytechnic, Zhejiang, People’s Republic of ChinaCorrespondence: Bi-e TangFaculty of Medicine, Jinhua Polytechnic, No.
Wu M   +6 more
doaj  

ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees

open access: yesScientific Reports, 2017
Honey bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world.
Scott T. O’Neal   +2 more
doaj   +1 more source

Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues

open access: yesPharmaceutics, 2017
Various diseases such as type 2 diabetes (T2D) may alter drug clearance. The objective of this study was to evaluate the effects of T2D on CYP450 expressions and activities using high-fat diet (HFD) as a model of obesity-dependent diabetes in C57BL6 mice.
Sarah Maximos   +4 more
doaj   +1 more source

Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine’s Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes

open access: yesPharmaceutics
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co ...
Xuefen Yin   +5 more
doaj   +1 more source

Clinical Experience with Tolbutamide [PDF]

open access: yesBMJ, 1957
G, WALKER   +3 more
openaire   +2 more sources

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