Results 61 to 70 of about 15,995 (210)

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

THE TREATMENT OF DIABETES MELLITUS WITH ORAL TOLBUTAMIDE

, 1957
Experience in the treatment of 76 diabetic patients with tolbutamide is described. In 25 patients the drug was discontinued after trials of from 1 week to several months because of poor diabetic control.
Allen Gold
core   +1 more source

Effects of Cimetidine, Ranitidine and Omeprazole on Tolbutamide Pharmacokinetics

, 1995
This randomized, four-way crossover study in 16 healthy subjects compared the effects of cimetidine 800 mg, ranitidine 300 mg and omeprazole 40 mg against placebo given daily after breakfast for seven days on the pharmacokinetics of a single oral dose of
F G P Mullins, A Khan, S Toon, B L Holt
core   +1 more source

Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam [PDF]

, 2017
Background and Objectives: Cytochrome P450 2C9 (CYP2C9) is involved in the biotransformation of many commonly used drugs, and significant drug interactions have been reported for CYP2C9 substrates.
Ng, WT, Chappell, J, Twelves, C, Jill Chappell, Wee Teck Ng, Everett J. Perkins, Posada, M, P. Kellie Turner, Perkins, EJ, Kellie Turner, P, Maria Posada, Chris Twelves   +11 more
core   +1 more source

Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention - a retrospective nationwide cohort study

Cardiovascular Diabetology, 2010
Background The optimum oral pharmacological treatment of diabetes mellitus to reduce cardiovascular disease and mortality following myocardial infarction has not been established.
Jørgensen Casper H, Gislason Gunnar H, Andersson Charlotte, Ahlehoff Ole, Charlot Mette, Schramm Tina K, Vaag Allan, Abildstrøm Steen Z, Torp-Pedersen Christian, Hansen Peter R   +9 more
doaj   +1 more source

Post-hypoxic recovery of respiratory rhythm generation is gender dependent. [PDF]

PLoS ONE, 2013
The preBötzinger complex (preBötC) is a critical neuronal network for the generation of breathing. Lesioning the preBötC abolishes respiration, while when isolated in vitro, the preBötC continues to generate respiratory rhythmic activity.
Alfredo J Garcia, Naama Rotem-Kohavi, Atsushi Doi, Jan-Marino Ramirez   +3 more
doaj   +1 more source

The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Frontiers in Pharmacology, 2018
Since the implementation of several legislations to improve pediatric drug research, more pediatric clinical trials are being performed. In order to optimize these pediatric trials, adequate preclinical data are necessary, which are usually obtained by ...
Joske Millecam, Laura De Clerck, Elisabeth Govaert, Mathias Devreese, Elke Gasthuys, Wim Schelstraete, Dieter Deforce, Lies De Bock, Jan Van Bocxlaer, Stanislas Sys, Siska Croubels   +10 more
doaj   +1 more source

Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes

Scientific Reports, 2021
The gene KCNJ11 encodes Kir6.2 a major subunit of the ATP-sensitive potassium channel (KATP) expressed in both the pancreas and brain. Heterozygous gain of function mutations in KCNJ11 can cause neonatal diabetes mellitus (NDM).
Gokhan Dalgin, Andrew K. Tryba, Ashley P. Cohen, Soo-Young Park, Louis H. Philipson, Siri Atma W. Greeley, Alfredo J. Garcia   +6 more
doaj   +1 more source

Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells

Journal of Diabetes Research, 2016
Small and big mouse islets were compared with special reference to their content of glucagon-producing α-cells and somatostatin-producing δ-cells. Areas stained for glucagon and somatostatin were measured in the largest cross section of small (diameter <
Joey Lau, Eva Grapengiesser, Bo Hellman
doaj   +1 more source

In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States

Molecules, 2017
Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder.
Agnieszka Szkudlarek, Danuta Pentak, Anna Ploch, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk   +4 more
doaj   +1 more source