Results 81 to 90 of about 15,995 (210)
ChemMedChem, Volume 21, Issue 7, 14 April 2026.A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi +24 more
wiley +1 more source
Secretion from Islets and Single Islet Cells following Cryopreservation
Cell Transplantation, 1999 The ability to cryopreserve pancreatic islets has allowed the development of low-temperature banks that permit pooling of islets from multiple donors and allows time for sterility and viability testing.
Jonathan R. T. Lakey Ph.D. +3 more
doaj +1 more source
TOLBUTAMIDE HYPOGLYCEMIA IN ACUTELY DEPANCREATIZED DOGS * t
, 1958 The hypoglycemic activity of tolbutamide and related compounds is well established; however, their mode of action is still debated. Several theories have been postulated (1-5).
Edward Meilman +2 more
core
Biochemistry Research International, 2018 Oldenlandia diffusa has been used to treat various cancers. Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine. Currently, the problem that remains is the effective treatment in drug-drug interaction situation.
Yiping Lin +5 more
doaj +1 more source
Tolbutamide inhibits glucagon-induced phosphorylation of 6PF-2-K/Fru-2,6-P2ase in rat hepatocytes
, 1995 In previous studies, we demonstrated that tolbutamide inhibits a phosphorylation of hepatic 6-phosphofructo-2-kinase (6PF-2-K)/fructose-2,6-bisphosphatase (Fru-2,6-P2ase) catalyzed by the adenosine 3',5'-cyclic monophosphate-dependent protein kinase in a
T. Kaneko +4 more
core +1 more source
The effects of tolbutamide on lipoproteins, lipoprotein lipase and hormone-sensitive lipase
, 1999 Type 2 diabetic patients are at increased risk to develop atherosclerotic vascular disease. These patients are often treated with sulphonylurea derivatives, and it has been suggested that this treatment might contribute to the increased atherosclerotic ...
Bjorgell, P +3 more
core +2 more sources
Calycosin Influences the Metabolism of Five Probe Drugs in Rats
Drug Design, Development and Therapy, 2020 Mei-ling Wu, Yi-ping Lin, Yan-li Wei, Hong-jian Du, Xiao-qian Ying, Wen-zhuang Tan, Bi-e Tang Faculty of Medicine, Jinhua Polytechnic, Zhejiang, People’s Republic of ChinaCorrespondence: Bi-e TangFaculty of Medicine, Jinhua Polytechnic, No.
Wu M +6 more
doaj
Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver
, 1986 In isolated perfused livers of 24-h fasted rats, perfused with lactate (2 mM), pyruvate (0.5 mM), or dihydroxyacetone (1 mM), infusion of tolbutamide (0.5 mM) very rapidly (within 3 min) inhibited the rate of gluconeogenesis.
T. B. Patel
core +1 more source
ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees
Scientific Reports, 2017 Honey bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world.
Scott T. O’Neal +2 more
doaj +1 more source
Proliferation of C6 glioma cells is blunted by the increase in gap junction communication caused by tolbutamide [PDF]
, 2001 We have previously reported that tolbutamide prevents the inhibition of gap junction communication in astrocytes. Here, we show that tolbutamide increases gap junction communication and connexin 43 expression in poorly coupled C6 glioma cells.
Sánchez-Alvarez, Rosa +11 more
core +1 more source