Results 81 to 90 of about 20,169 (222)

The prevention of type 2 diabetes [PDF]

, 2008
Type 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action—potential targets of preventive interventions—are impaired.
A Keech, A Mari, A Ramachandran, A Ramachandran, AF Dixon, C Weyer, CC Jensen, CL Gillies, CY Pan, D Simmons, D Simmons, David M Nathan, David Marrero, DE Laaksonen, DJ Freeman, DM Eddy, DM Nathan, DM Nathan, DM Nathan, DW Satterfield, E Marlow, EA Walker, F Rubino, G Bjärås, G Sartor, George A Bray, H Hämäläinen, H Keen, HC Gerstein, J Bosch, J Lindström, J Meece, J Tuomilehto, J Wang, JB Dixon, JC Florez, JC Florez, JD Holcomb, Jill P Crandall, JL Chiasson, JL Chiasson, Jose C Florez, JS Torgerson, K Kosaka, KG Rowley, KM Narayan, L Sjöström, L Sjöström, M Daniel, Mary Hoskin, MC Seidel, MK Mau, MM Engelgau, MM Engelgau, MP Stern, MR Carnethon, NI Teufel, O Laukkanen, P Goede, PS Sever, PW Wilson, R Collins, R Ratner, RF Hamman, RJ Jarrett, RP Trevino, RR Holman, RT Ackermann, RT Ackermann, S Yusuf, SB Heymsfield, SD Long, SE Kahn, SE Kahn, SE Nissen, SL Edelstein, SL Norris, SM Vijgen, Steven E Kahn, Steven M Haffner, T Saaristo, TA Buchanan, V Lyssenko, VV Cook, W Yang, WC Knowler, WC Knowler, WC Knowler, WH Herman, William C Knowler, WJ Pories, WJ Pories, WJ Pories, XR Pan   +93 more
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Loss of Beta‐Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes

MedComm, Volume 7, Issue 2, February 2026.
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Sumit Patel, Zihan Yan, Maria S. Remedi
wiley   +1 more source

Beyond the Michaelis–Menten: Evaluation of a tQSSA‐Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu, Yun Min Song, Sang Kyum Kim, Hwi‐yeol Yun, Soyoung Lee, Jae Kyoung Kim, Jung‐woo Chae   +6 more
wiley   +1 more source

Antioxidant plants and diabetes mellitus [PDF]

, 2015
The incidence of diabetes mellitus (DM) is increasing rapidly and it is expected to increase by 2030. Other than currently available therapeutic options, there are a lot of herbal medicines, which have been recommended for its treatment. Herbal medicines
Abdollahi, Adeneye, Adeneye, Adeneye, Adeneye, Ajabshir, Ajikumaran, Amini, Amiri, Amirmohammadi, Aragão, Ardalan, Ardalan, Ardalan, Asadi, Asadi-Samani, Asgari, Asgary, Asgary, Aslan, Aslan, Ayodhya, Badole, Bagheri, Bagheri, Bahmani, Bahmani, Bahmani, Baradaran, Baradaran, Baradaran, Baradaran, Baradaran, Bavarva, Beladi-Mousavi, Beladi-Mousavi, Bhaskar, Boussageon, Cemek, Chakrabarti, Chandra, Chausmer, Chen, Delfan, Deutschländer, Dewanjee, Dhanabal, Dhanabal, Dimo, Dimo, Eidi, Eurich, Fatima, Fikree, Ghaderian, Ghamarian, Gholamhoseinian, Gohari, Gokce, Greenland, Habibuddin, Hajian, Hajivandi, Hannan, Heidarian, Hulbert, Hung, Isah, Ju, Jung, Kafeshani, Kamgang, Kamtchouing, Kamtchouing, Karimi, Kazemi, Khookhor, Kim, Kotowaroo, Krisanapun, Kumar, Leu, Li, Lima, Madihi, Madihi, Mai, Mardani, Mathews, Meddah, Miller, Miura, Mogharabi, Momo, Motamedi, Murugesh, Narendhirakannan, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nasri, Nazar, Nazar, Ndiaye, Odetola, Ojewole, Okokon, Oliveira, Pandikumar, Pareek, Park, Park, Rabiei, Rabiei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaei, Rafieian-Kopaie, Rafieian-Kopaie, Rahimi, Rahimi, Rahimi, Rahimian, Rajagopal, Raut, Rauter, Roshan, Rouhi, Saki, Sangameswaran, Schoenfelder, Setorki, Shahbazian, Shamsi, Sharma, Shen, Shinde, Shirwaikar, Shirzad, Shirzad, Shirzad, Shoji, Sivajothi, Somani, Song, Sriplang, Subash-Babu, Suzuki, Taghikhani, Taheri, Tamadon, Tamadon, Tamadon, Tavafi, Tavafi, Tavafi, Tavakoli, Tolouian, Turdi, Venkatesh, Wiernsperger, Zanatta, Zheng   +183 more
core   +3 more sources

Secretion from Islets and Single Islet Cells following Cryopreservation

Cell Transplantation, 1999
The ability to cryopreserve pancreatic islets has allowed the development of low-temperature banks that permit pooling of islets from multiple donors and allows time for sterility and viability testing.
Jonathan R. T. Lakey Ph.D., Craig A. Aspinwall, Thomas J. Cavanagh, Robert T. Kennedy   +3 more
doaj   +1 more source

Structure determination of tolbutamide [PDF]

, 1981
N-​[(Butylamino)​carbonyl]​-​4-​methylbenzenesulfonamide, is an antidiabetic drug which crystd. in orthorhombic space group Pn21a, with a 20.16(2)​, b 9.05(1)​, c 7.85(1) Å; Z = 4, d.(exptl.) = 1.24 and d.(calcd.) = 1.25 for Z = 4.
Nirmala, K.A., Sake Gowda, D.S.
core   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MS/MS

Biochemistry Research International, 2018
Oldenlandia diffusa has been used to treat various cancers. Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine. Currently, the problem that remains is the effective treatment in drug-drug interaction situation.
Yiping Lin, Yanli Wei, Xiaoxia Hu, Meilling Wu, Xiaoqian Ying, Mingxing Ding   +5 more
doaj   +1 more source

K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A, Comini, L, Ferrari, R, Hubank, M, Knight, RA, Latchman, DS, Lawrence, KM, Pasini, E, Scarabelli, T, Stephanou, A, Tinker, A, Townsend, PA   +11 more
core  

Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons [PDF]

, 2002
The expression and properties of ionic channels were investigated in dissociated neurons from neonatal and adult rat intracardiac ganglia. Changes in the hyperpolarization-activated and ATP-sensitive K+ conductances during postnatal development and their
A.A Harper, Anderson, Armour, BoSmith, Cuevas, D.J Adams, Gootman, Hirst, Hogg, Hogg, Huang, Liu, Quigley, R.C Hogg, Thompson, Thompson, Wallick, Xi-Moy   +17 more
core   +1 more source