Results 71 to 80 of about 16,123 (208)
Journal of Pharmaceutical Analysis, 2016 A sensitive and selective method using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC–ESI–MS) to determine the concentration of torasemide in human plasma samples was developed and validated ...
Lin Zhang +3 more
doaj +1 more source
Hypoglycemic effect of tolbutamide mediated by argentaffine cells
, 1960 The hypoglycemic effect of tolbutamide (Orinase) was completely eliminated in dogs in which both the submaxillary glands and the complete gastrointestinal tract were removed. It is postulated that argentaffine cells are mediating the hypoglycemic action
J. C. Calandra, Z. Z. Godlowski
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The characteristics of the microsomal hydroxylation of tolbutamide
, 1991 The in vitro metabolism of tolbutamide to the hydroxymethyl derivative was studied using hepatic microsomal homogenates. The hydroxymethyl metabolite was quantitated by HPLC. The hepatic microsomal hydroxylase was completely inhibited by carbon monoxide
Serge St-Hilaire, Pierre M. Bélanger
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Frontiers in Pharmacology, 2014 According to traditional Chinese medicine theories, Euphorbiae Pekinensis Radix and Glycyrrhizae Radix shouldn’t be used together in one prescription, because their interaction leads to an unexpected consequence.
Xinmin eWang +5 more
doaj +1 more source
eFood, Volume 7, Issue 3, June 2026.Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
Phase-Transition Thermodynamics of Tolbutamide
Tolbutamide is an active pharmaceutical substance used in the treatment of type 2 diabetes. In this work, we report the first measurement of the vapor pressure above the liquid and crystalline phases of tolbutamide employing fast scanning calorimetry ...
Boris N. Solomonov (1577815) +4 more
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Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels [PDF]
, 1996 Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel that is regulated by protein kinase A and cytosolic nucleotides. Previously, Sheppard and Welsh reported that the sulfonylureas glibenclamide and tolbutamide reduced ...
Schultz, B.D. +4 more
core +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
In Vitro Effects of Carbutamide and Tolbutamide on Isolated Frog Muscle
, 1958 Carbutamide and tolbutamide, sulfonylurea compounds which reduce the blood glucose concentration in intact animals, do not act like insulin in isolated frog muscle.
R. H. Dodd, D. R. H. Gourley
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Secretion from Islets and Single Islet Cells following Cryopreservation
Cell Transplantation, 1999 The ability to cryopreserve pancreatic islets has allowed the development of low-temperature banks that permit pooling of islets from multiple donors and allows time for sterility and viability testing.
Jonathan R. T. Lakey Ph.D. +3 more
doaj +1 more source