Results 71 to 80 of about 20,169 (222)

In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States

Molecules, 2017
Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder.
Agnieszka Szkudlarek, Danuta Pentak, Anna Ploch, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk   +4 more
doaj   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Nokwanda N. Ngcobo, Ntethelelo H. Sibiya
wiley   +1 more source

Determination of torasemide in human plasma and its bioequivalence study by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry

Journal of Pharmaceutical Analysis, 2016
A sensitive and selective method using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC–ESI–MS) to determine the concentration of torasemide in human plasma samples was developed and validated ...
Lin Zhang, Rulin Wang, Yuan Tian, Zunjian Zhang   +3 more
doaj   +1 more source

Oleate induces K_ATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge [PDF]

, 2017
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.The unsaturated fatty acid, oleate exhibits anorexigenic properties reducing food intake and hepatic glucose output.
Abdul-Ghani, Arany, Ashford, Beall, Beall, Beall, Boden, Bränström, Burke, Carrillo, Chai, Cintra, Claret, Craig Beall, Cruciani-Guglielmacci, De Feo, de Vries, Declercq, Dunn-Meynell, Echtay, Evans, Frederich, Gonzalez, Gremmels, Hisadome, Hoang, Ibrahim, Jabůrek, Jo, Julia M. Vlachaki Walker, Kang, Kim, Krauss, Lam, Lam, Lameloise, Larsson, Larsson, Le Foll, Levi, Levin, Levin, MacDonald, Mai, Malingriaux, Mao, Marc P.M. Soutar, Mathur, McGarry, Medvedev, Michael L.J. Ashford, Miki, Mirshamsi, Morgan, Murphy, Natali, Obici, Obici, Oprescu, Parton, Perry, Pocai, Richieri, Rory J. McCrimmon, Ruiz-Ramírez, Sanchis, Selma Dadak, Silver, Song, Stanley, Tucker, Wang, Wang, Zackova, Zhang, Zhang, Zhang, Zhou   +77 more
core   +3 more sources

Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial K+ buffering in central white matter

Experimental Physiology, Volume 111, Issue 3, Page 1313-1329, 1 March 2026.
Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley   +1 more source

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. [PDF]

, 2016
AIMS/HYPOTHESIS: Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeostasis and participate in the detection of hypoglycaemia.
Ashford, FB, Ashford, ML, Beall, C, Dadak, S, Du, Q, Gallagher, J, Hamilton, DL, Haythorne, E, Jovanović, A, Logie, L, McCrimmon, RJ, Soutar, MP, Wright, K   +12 more
core   +1 more source

Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells

The Journal of Physiology, Volume 604, Issue 5, Page 1820-1839, 1 March 2026.
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira, Daniel Morales‐Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Angel Cogolludo, Francisco Perez‐Vizcaino, Maria Sancho   +7 more
wiley   +1 more source

Microscale Affinity Chromatography for Biointeraction Analysis: Strategies, Principles and Applications

Journal of Separation Science, Volume 49, Issue 2, February 2026.
ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage, Nigar Sultana Pinky, B. K. Sajeeb, Md Masudur Rahman, Harshana Olupathage, Samiul Alim, Isaac Kyei, Zoe Zingler, Sanduni Heenkenda   +8 more
wiley   +1 more source

In vitro and in vivo assessment of CYP2C9–mediated herb–herb interaction of Euphorbiae Pekinensis Radix and Glycyrrhizae Radix

Frontiers in Pharmacology, 2014
According to traditional Chinese medicine theories, Euphorbiae Pekinensis Radix and Glycyrrhizae Radix shouldn’t be used together in one prescription, because their interaction leads to an unexpected consequence.
Xinmin eWang, Yunru ePeng, Xinyue eJing, Dawei eQian, Yuping eTang, Jin-ao eDuan   +5 more
doaj   +1 more source