Results 1 to 10 of about 989,753 (307)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin [PDF]

Kaohsiung Journal of Medical Sciences
Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported.
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
doaj   +2 more sources

The contrasting effects of two antimalarial drugs on insulin secretion [PDF]

Cellular and Molecular Life Sciences
Quinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu, Fengran Xiong, Qianrui Zhang, Ruxuan Zhao, Chenyang Zhang, Gang Wei, Jinkui Yang   +6 more
doaj   +2 more sources

Molecular and Cellular Bases of Lipodystrophy Syndromes

Frontiers in Endocrinology, 2022
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
Jamila Zammouri, Camille Vatier, Camille Vatier, Emilie Capel, Martine Auclair, Caroline Storey-London, Elise Bismuth, Héléna Mosbah, Héléna Mosbah, Bruno Donadille, Bruno Donadille, Sonja Janmaat, Sonja Janmaat, Bruno Fève, Bruno Fève, Isabelle Jéru, Isabelle Jéru, Isabelle Jéru, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux   +20 more
doaj   +1 more source

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges

Frontiers in Endocrinology, 2022
Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a mild hyperglycemia, mainly due to a higher blood glucose threshold for ...
José Timsit, José Timsit, José Timsit, Cécile Ciangura, Cécile Ciangura, Cécile Ciangura, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Cécile Saint-Martin, Cécile Saint-Martin, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot   +14 more
doaj   +1 more source

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases, 2022
Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National
H. Mosbah, B. Donadille, C. Vatier, S. Janmaat, M. Atlan, C. Badens, P. Barat, S. Béliard, J. Beltrand, R. Ben Yaou, E. Bismuth, F. Boccara, B. Cariou, M. Chaouat, G. Charriot, S. Christin-Maitre, M. De Kerdanet, B. Delemer, E. Disse, N. Dubois, B. Eymard, B. Fève, O. Lascols, P. Mathurin, E. Nobécourt, A. Poujol-Robert, G. Prevost, P. Richard, J. Sellam, I. Tauveron, D. Treboz, B. Vergès, V. Vermot-Desroches, K. Wahbi, I. Jéru, M. C. Vantyghem, C. Vigouroux   +36 more
doaj   +1 more source

THE HYPOPHYSIS AND SECRETION OF INSULIN [PDF]

Journal of Experimental Medicine, 1942
The ability of the pancreas, from various types of dogs, to correct diabetic hyperglycemia has been studied (Table XI). The pancreas from one animal was united by a vascular union with the neck blood vessels of another dog which had been pancreatectomized for 20 hours. The time necessary to reduce the blood sugar level to 120 mg.
Houssay, Bernardo Alberto, Foglia, Virgilio G., Smyth, F. S., Rietti, Ciro T., Houssay, Alberto B.   +4 more
openaire   +3 more sources

Insulin secretion assays in an engineered MIN6 cell line

MethodsX, 2023
Insulin secretion from pancreatic beta cells is crucial for maintaining glucose homeostasis. The murine insulinoma derived MIN6 cell line is commonly used as a model for insulin secretion studies. However, its glucose responsiveness wanes with passaging,
Liu Yang, Wenbiao Chen
doaj   +1 more source

Calmodulin and insulin secretion [PDF]

Diabetologia, 1982
It is clear that calcium ions are of considerable importance as a second messenger in insulin secretion. There is increasing evidence that calmodulin, a ubiquitous intracellular regulatory protein that mediates calcium-dependent processes, has a fundamental role in stimulus-secretion coupling.
S, Tomlinson, S W, Walker, B L, Brown
openaire   +2 more sources

MiR-184 regulates insulin secretion through repression of Slc25a22 [PDF]

PeerJ, 2013
Insulin secretion from pancreatic β-cells plays an essential role in blood glucose homeostasis and type 2 diabetes. Many genes are involved in the secretion of insulin and most of these genes can be targeted by microRNAs (miRNAs).
Sumiyo Morita, Takuro Horii, Mika Kimura, Izuho Hatada   +3 more
doaj   +2 more sources

Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Metabolites, 2021
Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while ...
Alexis C. Wood, Elizabeth T. Jensen, Alain G. Bertoni, Gautam Ramesh, Stephen S. Rich, Jerome I. Rotter, Yii-Der I. Chen, Mark O. Goodarzi   +7 more
doaj   +1 more source