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Pancreatic Thyrotropin Releasing Hormone and Mechanism of Insulin Secretion
Cellular Physiology and Biochemistry, 2018 Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin.
Vladimír Štrbák
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Journal of Diabetes Research, 2017 The dynamics of insulin secretion were characterized in response to a variety of physiological and pharmacological stimulators and other compounds in perifused pseudoislets generated from cells of the EndoC-βH1 β-cell line.
Hiroki Teraoku, Sigurd Lenzen
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Secrets of insulin and IGF-1 regulation of insulin secretion revealed [PDF]
Biochemical Journal, 2004 There has been ongoing controversy over the respective roles of insulin-like growth factor-1 receptors and insulin receptors in controlling insulin release from β-cells of the pancreas. An acute knock-down experiment exploiting small interfering RNA approaches provides a resolution: both are required.
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Scientific Reports, 2017 In obesity fasting levels of both glucagon and insulin are elevated. In these subjects fasting levels of the free fatty acid palmitate are raised. We have demonstrated that palmitate enhances glucose-stimulated insulin secretion from isolated human ...
H. Kristinsson +5 more
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PLoS ONE, 2016 Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin sensitivity, yet most T2D loci identified to date influence insulin secretion.
Jacob M Keaton +15 more
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The Journal of Maternal-Fetal & Neonatal MedicineObjectives This study aimed to develop an efficient method for evaluating islet function in pregnant women by analyzing the peak times of plasma glucose and insulin secretion during an oral glucose tolerance test.Methods This prospective study included ...
Huaying Ye, Yangyang Chang, Huaping Li
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Insulin secretion and capsaicin [PDF]
The American Journal of Clinical Nutrition, 2007 Alevizos, Alevizos +3 more
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JCI InsightInsulin secretion from pancreatic β cells is initiated by membrane potential depolarization, followed by activation of voltage-gated Ca2+ channels to trigger Ca2+-mediated insulin vesicle fusion with the β cell plasma membrane.
Tarek Mohamed Abd El-Aziz +7 more
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The Journal of Clinical InvestigationPancreatic β cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here, we report that succinate receptor 1 (SUCNR1) is expressed in β cells and is upregulated in hyperglycemic states in mice and ...
Joan Sabadell-Basallote +19 more
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