Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis
Nature Communications, 2022 How pancreatic islets of Langerhans are built during development is incompletely understood. Here the authors find that Synaptotagmin-13 mediates remodeling of cell-matrix adhesion to regulate endocrine cell egression and islet morphogenesis.
Mostafa Bakhti +17 more
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Effect of different fractions of Hibiscus rosa sinensis leaf extract on islets of Langerhans and antioxidant activity in non-obese diabetic (NOD) mouse [PDF]
, 2011 The present investigation was undertaken to study the effect of Hibiscus rosa sinensis leaf extract fractions on islets of Langerhans, total antioxidant activity in non-obese diabetic (NOD) mouse. Two sets of experiments were conducted.
Moqbel, Fahmi S., Naik, Prakash R.
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In Vivo Imaging of Transplanted Pancreatic Islets
Frontiers in Endocrinology, 2018 The beta-cells in the islets of Langerhans in the pancreas secrete insulin and play an important role in glucose homeostasis. Diabetes, characterized by hyperglycemia, results from an absolute or a relative deficiency of the pancreatic beta-cell mass ...
Donghee Kim +3 more
doaj +1 more source
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. [PDF]
, 1995 Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete destruction of the insulin-producing islets of Langerhans.
Bluestone, JA +7 more
core
Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease [PDF]
, 2017 Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing,
Arda, H. Efsun +14 more
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Anchored phosphatases modulate glucose homeostasis. [PDF]
, 2012 Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo +12 more
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Isolation of Adult Porcine Islets of Langerhans
Cell Transplantation, 2000 While human islet allotransplantation is limited due to the shortage of donors, pig islet xenotransplantation appears to be a possible alternative. Enzymatic digestion is the method most commonly used for adult pig islet isolation, but since the description of the semiautomated isolation technique in the late 1980s, yields of pig islet isolations have ...
Toso, Christian +5 more
openaire +5 more sources
Preganglionic innervation of the pancreas islet cells in the rat [PDF]
, 1984 The position and number of preganglionic somata innervating the insulin-secreting β-cells of the endocrine pancreas were investigated in Wistar rats.
Horst, G.J. ter, +4 more
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Jurnal Veteriner, 2012 Morphology, distribution and relative frequency of endocrine cells in the pancreas Bullfrog (Ranacatesbeiana) were studied using conventional and immunohistochemical methods.
I Ketut Mudite Adnyane +3 more
doaj
Вестник трансплантологии и искусственных органов, 2017 Introduction. Extracellular matrix play an essential role in providing structural integrity and physiological support to Langerhans islets in pancreas. Imitation of the native microenvironment can be useful for viability of isolated pancreatic islets in ...
L. A. Kirsanova +3 more
doaj +1 more source