Results 11 to 20 of about 342,036 (317)

The contrasting effects of two antimalarial drugs on insulin secretion [PDF]

Cellular and Molecular Life Sciences
Quinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu, Fengran Xiong, Qianrui Zhang, Ruxuan Zhao, Chenyang Zhang, Gang Wei, Jinkui Yang   +6 more
doaj   +2 more sources

Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men

BMJ Open Diabetes Research & Care, 2021
Introduction It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations.
Stephanie A Amiel, Riccardo C Bonadonna, Louise M Goff, Meera Ladwa, Oluwatoyosi Bello, Olah Hakim, Fariba Shojaee-Moradie, Maria Linda Boselli, Geoff Charles-Edwards, Janet Peacock, A Margot Umpleby   +10 more
doaj   +1 more source

Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion

Molecular Metabolism, 2022
Objectives: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here,
Liu Yang, Margret A. Fye, Bingyuan Yang, Zihan Tang, Yue Zhang, Sander Haigh, Brittney A. Covington, Kai Bracey, Justin W. Taraska, Irina Kaverina, Shen Qu, Wenbiao Chen   +11 more
doaj   +1 more source

On insulin secretion [PDF]

Diabetologia, 1981
Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells.
openaire   +2 more sources

European lipodystrophy registry: background and structure

Orphanet Journal of Rare Diseases, 2020
Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein, Claire Adams, Baris Akinci, Giovanni Ceccarini, Maria Rosaria D’Apice, Alessandra Gambineri, Raoul C. M. Hennekam, Isabelle Jeru, Giovanna Lattanzi, Konstanze Miehle, Gabriele Nagel, Giuseppe Novelli, Ferruccio Santini, Ermelinda Santos Silva, David B. Savage, Paolo Sbraccia, Jannik Schaaf, Ekaterina Sorkina, George Tanteles, Marie-Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Elena Vorona, David Araújo-Vilar, Martin Wabitsch   +24 more
doaj   +1 more source

Exploring mechanisms of insulin secretion regulators using C. elegans [PDF]

, 2022
Diabetes mellitus is a group of disorders characterized by disrupted glucose homeostasis. Diabetes is one of the most dangerous diseases worldwide since it affects currently more than 500 million people. The pathogenesis of the disease is associated with
Podraza-Farhanieh, Agnieszka
core   +1 more source

Deoxysugars and Insulin Secretion

Hormone and Metabolic Research, 1977
It has been shown that a deoxysugar, D(+)-digitoxose, inhibits glucose-induced insulin release without inhibiting the glucose oxidation rates of the islets. In the present study the effect on insulin release of several other common deoxysugar (L-fucose, D-fucose, L-rhamnose, 2-deoxy-D-galactose and 2-deoxy-D-ribose) was investigated. We have found that
García-Hermida, Ofelia, Gómez-Acebo, J.   +1 more
openaire   +3 more sources

Calmodulin and insulin secretion [PDF]

Diabetologia, 1982
It is clear that calcium ions are of considerable importance as a second messenger in insulin secretion. There is increasing evidence that calmodulin, a ubiquitous intracellular regulatory protein that mediates calcium-dependent processes, has a fundamental role in stimulus-secretion coupling.
S, Tomlinson, S W, Walker, B L, Brown
openaire   +2 more sources

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on [PDF]

, 2008
In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma
Hills, Claire E., Hodgkin, M. N., Squires, Paul E.   +2 more
core   +1 more source