Results 11 to 20 of about 989,753 (307)
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J. +2 more
core +4 more sources
Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion. [PDF]
PLoS ONE, 2016 BACKGROUND:Insulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas.
Jose E Galgani +6 more
doaj +1 more source
Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
Frontiers in Endocrinology, 2021 BackgroundThe increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes.
Tao Yuan +10 more
doaj +1 more source
Modulation of insulin secretion by RBFOX2-mediated alternative splicing
Nature Communications, 2023 Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly fine-tune ...
Nicole D. Moss +7 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2021 Introduction It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations.
Stephanie A Amiel +10 more
doaj +1 more source
Diabetologia, 1981 Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells.
openaire +2 more sources
European lipodystrophy registry: background and structure
Orphanet Journal of Rare Diseases, 2020 Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein +24 more
doaj +1 more source
Molecular Metabolism, 2022 Objectives: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here,
Liu Yang +11 more
doaj +1 more source
Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]
, 2010 AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ +20 more
core +1 more source
The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on [PDF]
, 2008 In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma
Hills, Claire E. +2 more
core +1 more source