Results 41 to 50 of about 989,753 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

THE INSUFFICIENCY OF INSULIN SECRETION IN SPONTANEOUSLY HYPERTENSIVE RATS [PDF]

, 1992
The influence of the sympathetic nervous system on insulin secretion was investigated in both spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY).
Fujimoto, Chihiro
core  

A new general glucose homeostatic model using a proportional-integral-derivative controller [PDF]

, 2011
The glucose-insulin system is a challenging process to model due to the feedback mechanisms present, hence the implementation of a model-based approach to the system is an on-going and challenging research area.
S.M. Poucher, E.M. Watson, Chappell, M. J. (Michael J.), Yates, J. W. T., Ducrozet, F., M.J. Chappell, Poucher, S. M., J.W.T. Yates, Watson, E. M., F. Ducrozet   +9 more
core   +1 more source

Bromocriptine and insulin secretion

Bioscience Reports, 1982
The dopaminergic drug bromocriptine inhibited the release of insulin from isolated mouse pancreatic islets. The effect was counteracted by haloperidol or pimozide. It is suggested that insulin release may be inhibited through activation of D-2 dopaminergic receptors in the pancreatic beta-cells.
E E, El-Denshary, N A, Ismail, E, Gagerman, J, Sehlin, I B, Täljedal   +4 more
openaire   +2 more sources

Insulin secretion and insulin-producing tumors [PDF]

Expert Review of Endocrinology & Metabolism, 2010
Insulinomas are rare neuroendocrine tumors of pancreatic islet cells that retain the ability to produce and secrete insulin. In contrast to normally differentiated β-cells, insulinoma cells continue to secrete insulin and proinsulin at low blood glucose. This deregulated insulin secretion manifests clinically as fasting hypoglycemia.
Jean-Marc, Guettier, Phillip, Gorden
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism [PDF]

, 2004
The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function.
Pljesa, Steva, Komadina, Ljiljana, Milic, Natasa, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Perunicic-Pekovic, Gordana   +5 more
core  

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Steffens, A.B., P. G. Luiten, van der Gugten, J., Steffens, A.B.,, Gugten, J. van der,, J. van der Gugten, Luiten, P.G.M., A. B. Steffens, Luiten, P.G.M.,, Damsma, G., G. Damsma, Damsma, G.,   +11 more
core   +1 more source

Maturity Onset Diabetes of the Young (MODY): French National Diagnosis and Care Protocol (PNDS, Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases
MODY (Maturity-Onset Diabetes of the Young) is characterized by autosomal dominant mode of inheritance, early onset of diabetes in the absence of autoimmunity directed to pancreatic β-cells, impaired insulin secretory capacity, however, maintained over ...
Danièle Dubois-Laforgue, Bruno Donadille, Cécile Ciangura , Chloé Amouyal, Jean-Baptiste Arnoux, Pascal Barat, Sabine Baron, Jacques Beltrand, Elise Bismuth, Clara Bouché, Jean-Claude Carel, Hélène Cavé, Sophie Christin-Maitre, Delphine Collin-Chavagnac, Christiane Damgé, Brigitte Delemer, Pierre Gourdy , Sophie Jacqueminet, Sonja Janmaat , Marc de Kerdanet, Laurence Kessler, Dominique Langin , Jean-Charles Nault, Jacky Nizard, Michel Polak , Rachel Reynaud, Cécile Saint-Martin, Igor Tauveron, René Valéro, Anne Vambergue, Marie-Christine Vantyghem, Camille Vatier, Marc Nicolino, Christine Bellanné-Chantelot, Corinne Vigouroux   +34 more
doaj   +1 more source

Low, but Physiological, Concentration of GLP-1 Stimulates Insulin Secretion Independent of the cAMP-Dependent Protein Kinase Pathway

Journal of Pharmacological Sciences, 2008
Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations.
Makoto Shigeto, Masashi Katsura, Masafumi Matsuda, Seitaro Ohkuma, Kohei Kaku   +4 more
doaj   +1 more source