Results 31 to 40 of about 342,036 (317)

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

, 2009
Pyruvate cycling has been implicated in glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells. The operation of some pyruvate cycling pathways is proposed to necessitate malate export from the mitochondria and NADP(+)-dependent ...
Gray, Joshua P., Pongratz, Rebecca L., Collis, Leon P., Heart, Emma, Smith, Peter J.S., Cline, Gary W.   +5 more
core   +1 more source

Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. [PDF]

PLoS ONE, 2016
Rosuvastatin is a member of the statin family. Like the other statins it is prescribed to lower cholesterol levels and thereby reduce the risk of cardiovascular events.
Vishal A Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt   +3 more
doaj   +1 more source

A new general glucose homeostatic model using a proportional-integral-derivative controller [PDF]

, 2011
The glucose-insulin system is a challenging process to model due to the feedback mechanisms present, hence the implementation of a model-based approach to the system is an on-going and challenging research area.
S.M. Poucher, E.M. Watson, Chappell, M. J. (Michael J.), Yates, J. W. T., Ducrozet, F., M.J. Chappell, Poucher, S. M., J.W.T. Yates, Watson, E. M., F. Ducrozet   +9 more
core   +1 more source

Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice. [PDF]

PLoS ONE, 2015
Infertility associated with obesity is characterized by abnormal hormone release from reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain insulin sensitivity upon peripheral insulin resistance.
Sara A DiVall, Danny Herrera, Bonnie Sklar, Sheng Wu, Fredric Wondisford, Sally Radovick, Andrew Wolfe   +6 more
doaj   +1 more source

Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center

Orphanet Journal of Rare Diseases
Background Rare syndromes of lipodystrophy and insulin-resistance display heterogeneous clinical expressions. Their early recognition, diagnosis and management are required to avoid long-term complications.
Bruno Donadille, Sonja Janmaat, Héléna Mosbah, Inès Belalem, Sophie Lamothe, Mariana Nedelcu, Anne-Sophie Jannot, Sophie Christin-Maitre, Bruno Fève, Camille Vatier, Corinne Vigouroux   +10 more
doaj   +1 more source

Autoantibodies directed against insulin receptor during the course of Castleman disease: a new case reaffirming autoimmune hypoglycemia as a relapse warning signal

European Journal of Case Reports in Internal Medicine
This case study presents the case of a 54-year-old human immunodeficiency virus (HIV)-positive male who developed type B insulin resistance syndrome (TBIRS) in conjunction with a relapse of human herpesvirus 8 (HHV8)-positive multicentric Castleman ...
Xavier Jannot, Martine Auclair, Martin Martinot, Amin Maazouzi, David Boutboul, Corinne Vigouroux, Yannick Dieudonné   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Steffens, A.B., P. G. Luiten, van der Gugten, J., Steffens, A.B.,, Gugten, J. van der,, J. van der Gugten, Luiten, P.G.M., A. B. Steffens, Luiten, P.G.M.,, Damsma, G., G. Damsma, Damsma, G.,   +11 more
core   +1 more source

Low, but Physiological, Concentration of GLP-1 Stimulates Insulin Secretion Independent of the cAMP-Dependent Protein Kinase Pathway

Journal of Pharmacological Sciences, 2008
Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations.
Makoto Shigeto, Masashi Katsura, Masafumi Matsuda, Seitaro Ohkuma, Kohei Kaku   +4 more
doaj   +1 more source

CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion

Frontiers in Endocrinology, 2021
AimDespite the enormous efforts to understand Congenital hyperinsulinism (CHI), up to 50% of the patients are genetically unexplained. We aimed to functionally characterize a novel candidate gene in CHI.PatientA 4-month-old boy presented severe ...
Yazeid Alhaidan, Yazeid Alhaidan, Yazeid Alhaidan, Yazeid Alhaidan, Henrik Thybo Christesen, Henrik Thybo Christesen, Henrik Thybo Christesen, Elena Lundberg, Mohammed A. Al Balwi, Mohammed A. Al Balwi, Mohammed A. Al Balwi, Klaus Brusgaard, Klaus Brusgaard, Klaus Brusgaard   +13 more
doaj   +1 more source