Results 21 to 30 of about 342,036 (317)

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Persaud, Shanta J.; id_orcid, Jones, Peter M.; id_orcid, Kitsou-Mylona, Isidora, Squires, Paul E., Jones, Peter M., Burns, Christopher J., Persaud, Shanta J.   +6 more
core   +1 more source

Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin

BMC Endocrine Disorders, 2012
Background In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed.
Jones Angus G, Besser Rachel EJ, Shields Beverley M, McDonald Timothy J, Hope Suzy V, Knight Bridget A, Hattersley Andrew T   +6 more
doaj   +1 more source

Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]

, 1984
Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
Steffens, A.B., Steffens, A.B.,, Luiten, P.G.M., Kuipers, F.; id_orcid, Luiten, P.G.M.,, Flik, G., Flik, G.,, Kuipers, F.,, Kuipers, F., Lotter, E.C., Lotter, E.C.,   +10 more
core   +1 more source

Effects of 1,5-anhydro-D-glucitol on insulin secretion both in in vitro and ex vivo pancreatic preparations

Journal of Pharmacological Sciences, 2022
Organ bath experiments are conventionally used to investigate the physiological actions and effects of hormones and drugs on organ responses. We developed an experimental method to reproduce insulin secretion from isolated rat pancreas preparations, to ...
Motoshi Ouchi, Asuka Morita, Keitaro Satoh, Shunsuke Kobayashi, Misao Terada, Hiroe Kon, Keitaro Hayashi, Tatsuya Suzuki, Kenzo Oba, Hitoshi Sugihara, Masahiro Yasutake, Naohiko Anzai, Tomoe Fujita   +12 more
doaj   +1 more source

The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Metabolites, 2021
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber, Nicholas B. Whitticar, Daniel R. Rochester, Kathryn L. Corbin, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source

Pathophysiology of insulin secretion [PDF]

Annales d'Endocrinologie, 2004
Defects in pancreatic islet beta-cell function play a major role in the development of diabetes mellitus. Type 1 diabetes is caused by a more or less rapid destruction of pancreatic beta cells, and the autoimmune process begins years before the beta-cell destruction becomes complete, thereby providing a window of opportunity for intervention.
openaire   +2 more sources

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion

Molecular Metabolism, 2020
Objectives: Glucose-stimulated insulin secretion is a critical function in the regulation of glucose homeostasis, and its deregulation is associated with the development of type 2 diabetes.
Dassine Berdous, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Maxime Jan, Clara Roujeau, Isabel C. Lopez-Mejia, Randall Mynatt, Bernard Thorens   +7 more
doaj   +1 more source

Pancreatic islets isolated from β₂ adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842

Acta Scientiarum: Biological Sciences, 2013
Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice ...
Anderson Carlos Marçal, Ana Paula Couto Davel, Angelo Rafael Carpinelli, Patrícia Chakur Brum, Luciana Venturini Rossoni, Carla Roberta de Oliveira Carvalho   +5 more
doaj   +1 more source

Aging and Insulin Secretion

Experimental Biology and Medicine, 1995
Aging in mammals has often been associated with decreased insulin secretion and a subsequent deterioration in the ability to maintain glucose homeostasis. However, recent studies have demonstrated that factors such as disease, obesity, and physical activity more closely reflect diminished insulin secretion rather than aging per se. Thus, the purpose of
M C, Coordt, R C, Ruhe, R B, McDonald
openaire   +2 more sources

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source