Results 21 to 30 of about 543,808 (360)
A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans [PDF]
, 2008 Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher +4 more
core +1 more source
Dynamin Is Functionally Coupled to Insulin Granule Exocytosis [PDF]
, 2007 The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation.
Gaisano, HY +7 more
core +2 more sources
Calmodulin and insulin secretion [PDF]
Diabetologia, 1982 It is clear that calcium ions are of considerable importance as a second messenger in insulin secretion. There is increasing evidence that calmodulin, a ubiquitous intracellular regulatory protein that mediates calcium-dependent processes, has a fundamental role in stimulus-secretion coupling.
S, Tomlinson, S W, Walker, B L, Brown
openaire +2 more sources
Sleep Disturbances and Glucose Metabolism in Older Adults: The Cardiovascular Health Study. [PDF]
, 2015 ObjectiveWe examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 ...
Biggs, Mary Lou +10 more
core +2 more sources
Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone [PDF]
, 2005 Background: Obesity associated hypertension is likely to be due to multiple mechanisms. Identification of the renin-angiotensin system (RAS) within adipose tissue does, however, suggest a potential causal role for it in obesity-associated hypertension ...
Chetty, Rajkumar +6 more
core +1 more source
E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]
, 2007 Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX +21 more
core +1 more source
BMC Endocrine Disorders, 2012 Background In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed.
Jones Angus G +6 more
doaj +1 more source
Consistency of compact and extended models of glucose-insulin homeostasis: The role of variable pancreatic reserve [PDF]
, 2019 Published compact and extended models of the glucose-insulin physiologic control system are compared, in order to understand why a specific functional form of the compact model proved to be necessary for a satisfactory representation of acute ...
De Gaetano, Andrea +2 more
core +1 more source
Journal of Pharmacological Sciences, 2022 Organ bath experiments are conventionally used to investigate the physiological actions and effects of hormones and drugs on organ responses. We developed an experimental method to reproduce insulin secretion from isolated rat pancreas preparations, to ...
Motoshi Ouchi +12 more
doaj +1 more source