Results 91 to 100 of about 20,169 (222)

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

open access: yesDrug Design, Development and Therapy, 2020
Mei-ling Wu, Yi-ping Lin, Yan-li Wei, Hong-jian Du, Xiao-qian Ying, Wen-zhuang Tan, Bi-e Tang Faculty of Medicine, Jinhua Polytechnic, Zhejiang, People’s Republic of ChinaCorrespondence: Bi-e TangFaculty of Medicine, Jinhua Polytechnic, No.
Wu M   +6 more
doaj  

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood [PDF]

open access: yes, 1973
The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has ...
Brown, TH   +6 more
core  

RNA-sequencing of WFS1-deficient pancreatic islets. [PDF]

open access: yes, 2016
Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in theWFS1gene.WFS1encodes an endoplasmic reticulum resident transmembrane protein.
Hugill, Alison   +2 more
core   +1 more source

ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees

open access: yesScientific Reports, 2017
Honey bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world.
Scott T. O’Neal   +2 more
doaj   +1 more source

Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues

open access: yesPharmaceutics, 2017
Various diseases such as type 2 diabetes (T2D) may alter drug clearance. The objective of this study was to evaluate the effects of T2D on CYP450 expressions and activities using high-fat diet (HFD) as a model of obesity-dependent diabetes in C57BL6 mice.
Sarah Maximos   +4 more
doaj   +1 more source

Nanocrystallization of Rare Tolbutamide Form V in Mesoporous MCM-41 Silica [PDF]

open access: yes, 2018
Encapsulation of pharmaceuticals inside nanoporous materials is of increasing interest due to their possible applications as new generation therapeutics, theranostic platforms, or smart devices.
Fabian, Laszlo   +4 more
core   +2 more sources

New Aspects of Neurotransmitter Release and Exocytosis: Involvement of Ca2+/Calmodulin-Dependent Phosphorylation of Synapsin I in Insulin Exocytosis

open access: yesJournal of Pharmacological Sciences, 2003
: The exocytosis of insulin from pancreatic β-cells is closely related to intracellular elevation of Ca2+. The effects of Ca2+ may be mediated by Ca2+/calmodulin-dependent protein kinase II (CaMKII).
Hideyuki Yamamoto   +3 more
doaj   +1 more source

Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs [PDF]

open access: yes, 2018
Introduction: Sulfonylurea antidiabetics are insulin secretogogues useful in the treatment of type 2 diabetic patients. The probability of adverse drug interactions is high in patients taking sulfonylureas and other drugs including herbal medicines ...
Balasubramaniam, Rajkapoor.   +1 more
core   +2 more sources

Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes [PDF]

open access: yes, 2014
In a previous study we reported the presence of a large conductance K+ channel in the membrane of endoplasmic reticulum (ER) from rat hepatocytes.
Eliassi, Afsaneh   +3 more
core  

Treatment of Diabetes With Oral Hypoglycemic Drugs [PDF]

open access: yes, 1966
Oral hypoglycemic drugs now available are of two types. The biguanides, of which phenformin (DBI) is the only one available, increase glucose utilization by muscles.
Moss, James M.
core   +1 more source

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