Results 91 to 100 of about 16,123 (208)
Structural optimization and vibrational analysis of an antidiabetic drug: tolbutamide
, 2015 The purpose of this study is to investigate the vibrational spectrum of tolbutamide by ab initio techniques in combination with experimental studies.
Çağrı Çırak (536796) +4 more
core +1 more source
Pharmaceutics, 2017 Various diseases such as type 2 diabetes (T2D) may alter drug clearance. The objective of this study was to evaluate the effects of T2D on CYP450 expressions and activities using high-fat diet (HFD) as a model of obesity-dependent diabetes in C57BL6 mice.
Sarah Maximos +4 more
doaj +1 more source
Tolbutamide potentiates the volume-regulated anion channel current in rat pancreatic beta cells
, 2004 Aims/hypothesis. Hypoglycaemic sulphonylureas are thought to stimulate insulin release by binding to a sulphonylurea receptor, closing KATP channels and inducing electrical activity.
Brown, P. D., Davies, S., Best, L.
core +1 more source
, 2000 Arginine vasopressin (AVP), bombesin, and ACh increase cytosolic free Ca2+and potentiate glucose-induced insulin release by activating receptors linked to phospholipase C (PLC).
Christof Schöfl +5 more
core +1 more source
Solubility of Tolbutamide and Chlorpropamide in Supercritical Carbon Dioxide
, 2018 Tolbutamide and chlorpropamide are oral hypoglycemic drugs that are used to treat diabetic patients. In the context of employing these drugs in green pharmaceutical applications that make use of supercritical fluids, the solubility of tolbutamide and ...
Manna, Luigi +5 more
core +1 more source
Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria
1. The effect of tolbutamide on the oxidation rate, respiratory control index and P/0 ratio of intact rat liver mitochondria was studied. 2. Addition of more than 30 mg% tolbutamide apparently increased the state 4 respiration rate and decreased RCI ...
KATSUMATA, KAZUO, HAGIHARA, MASAKO
core
Effects of Self-Assembled Monolayers on Selective Crystallization of Tolbutamide
, 2016 Selective crystallization of tolbutamide on SAMs with the similar molecule structure of tolbutamide and the functional groups of methyl, trifluoromethyl, and phenyl respectively was studied through characterizations of XRD and crystal morphologies. It is
Anyuan Liu (2139871) +6 more
core +1 more source
Gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma
, 1972 An improved method for the gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma is described. The drugs are extracted into toluene, back-extracted into alkali and methylated with dimethylsulphate.
D R REDMAN, L F PRESCOTT
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, 1996 Mephenytoin, phenytoin and tolbutamide are metabolised by the cytochrome P-450 (CYP) 2C family. Recently, it has been shown that phenytoin and tolbutamide are metabolised by CYP2C9/10 whereas mephenytoin is metabolised by CYP2C19.
Desager, Jean-Pierre +2 more
core
, 2004 Congenital hyperinsulinism (CHI) is related to two main histological pancreas anomalies: focal adenomatous hyperplasia and diffuse beta-cell hypersecretion. Pharmacological tests to measure acute insulin responses (AIR) to peripheral i.v.
Irina Giurgea +38 more
core +1 more source