Results 101 to 110 of about 16,123 (208)

Modification of the hypoglycaemic response to tolbutamide and insulin by mebanazine—an inhibitor of monoamine oxidase

, 1965
Following reports of clinical changes in the carbohydrate metabolism of diabetic patients receiving mebanazine, possible interactions between mebanazine, adrenaline, tolbutamide and insulin have been studied in rats.
A M Barrett
core   +1 more source

Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine’s Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes

Pharmaceutics
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co ...
Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt   +5 more
doaj   +1 more source

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.

, 1986
The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic beta-cells was investigated using different configurations of the patch clamp technique.
Rorsman, Patrik, Rorsmann, P., Ohno-Shosaku, T, Ohnoshosaku, T., Trube, G., Trube, G, Rorsman, P   +6 more
core   +1 more source

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

, 1999
ATP-sensitive potassium channels (K(ATP)) are formed from four pore-forming Kir6.2 subunits complexed with four regulatory sulfonylurea receptor subunits (SUR1 in pancreatic beta-cells, SUR2A in heart).
Ashcroft, SJ, Ashcroft, FM, Ashfield, R, Gribble, FM, Ashcroft, Frances   +4 more
core   +1 more source

Tolbutamide [PDF]

, 2020
openaire   +3 more sources

Clinical Experience with Tolbutamide [PDF]

BMJ, 1957
G, WALKER, J D, SLATER, E K, WESTLAKE, J D, NABARRO   +3 more
openaire   +2 more sources

Relevance of the KATP channel function for the basal insulin hypersecretion of islets from female NZO mice. [PDF]

J Endocr Soc
Asuaje Pfeifer M, Brozek J, Grupe K, Wanitschke F, Scherneck S, Rustenbeck I.   +5 more
europepmc   +1 more source

Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse.

, 1993
The functional state of beta cells may influence the rate of their destruction in Type 1 (insulin-dependent) diabetes mellitus. We examined the effect of diazoxide, which inhibits insulin secretion, or tolbutamide, which stimulates insulin secretion ...
SIGNORE, Alberto, Williams AJ, Pozzilli P., Xu S, Gale EA, Krug J, Beales PE, Procaccini E   +7 more
core  

Physiologically based pharmacokinetic modeling of fluconazole: interpretation of gender-dependent pharmacokinetics and cytochrome P450 inhibition. [PDF]

Front Pharmacol
Ishida K, Tanna RS, Yang J, Lai Y.
europepmc   +1 more source

Partial restoration of counterregulatory circulating glucagon by dapagliflozin and low-dose glibenclamide in men with type 1 diabetes: in vitro studies and randomised clinical crossover trial. [PDF]

EBioMedicine
Gao R, Spiliotis I, Dou H, Hill TG, Kothegala L, Miranda C, Abiakam N, Coleman RL, White S, Adler A, Rorsman P.   +10 more
europepmc   +1 more source