Results 101 to 110 of about 20,169 (222)

Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine’s Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes

Pharmaceutics
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co ...
Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt   +5 more
doaj   +1 more source

Comparative study of the hypoglycemic and biochemical effects of Catharanthus roseus (Linn) g. apocynaceae (Madagascar periwinkle) and chlorpropamide (diabenese) on alloxan-induced diabetic rats [PDF]

, 2005
The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes were compared in alloxan-induced diabetic rats.
Iweala, E. E. J., Okeke, C. U.
core   +1 more source

Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs

Frontiers in Microbiology
Type 2 diabetes mellitus (T2DM) is an obesity-related disease claiming substantial global mortality annually. Current animal models of T2DM remain limited, with low success rates in establishing porcine models of high-fat diet (HFD)-induced T2DM.
Yanjun Wu, Jiayuan Mo, Jiayuan Mo, Qianguang Wang, Jialong Li, Jia Wei, Nuo Zhang, Yuanqiu Dong, Xiang Zhu, Taofeng Lu, Sicheng Huang, Sicheng Huang   +11 more
doaj   +1 more source

Impact of Fusarium mycotoxins on in vitro activity of major hepatic cytochrome P450 biotransformation enzymes in pigs [PDF]

, 2017
C
Croubels, Siska, Devreese, Mathias, Schelstraete, Wim   +2 more
core   +1 more source

The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]

, 1980
Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J, Francavilla, A, Jones, AF, Starzl, TE   +3 more
core  

Tolbutamide [PDF]

, 2020
openaire   +3 more sources

Clinical Experience with Tolbutamide [PDF]

BMJ, 1957
G, WALKER, J D, SLATER, E K, WESTLAKE, J D, NABARRO   +3 more
openaire   +2 more sources

The intravenous glucose tolerance test and the behaviour of the free fatty acids in the detection of latent diabetes mellitus [PDF]

, 1966
Dieterle, P., Eymer, K. P., Hofmann, G. G., Schwarz, K., Scriba, Peter Christian   +4 more
core  

Sesamin exhibits potential food-drug interactions through the inhibition of cytochrome P450s and human UDP-glucuronosyltransferases <i>in vitro</i>. [PDF]

RSC Adv
Yin H, Zhu L, Wang X, Wang Z, Wang H, Liu Y.   +5 more
europepmc   +1 more source

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects [PDF]

Heterozygous mutations in the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ATP-sensitive K(+) channel (K(ATP) channel), are a common cause of neonatal diabetes.
Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM
core