Results 111 to 120 of about 13,288 (170)

Pharmacogenetics of Tolbutamide Metabolism in Humans

Diabetes, 1978
This study was designed to focus on the genetic control of tolbutamide disposition in humans and to provide insight into the potential for high accrued blood levels in individuals receiving fixed dosage regimens. Tolbutamide was administered intravenously to 42 nondiabetic subjects, eight of their relatives, and to five sets of twins.
J, Scott, P L, Poffenbarger
exaly   +3 more sources

Tolbutamide and Truth

Annals of Internal Medicine, 1971
Excerpt To the editor: Dr. Schwartz's article on the tolbutamide controversy (ANNALS75:303-306, 1971) is revealing in its presentation of the moral dilemmas that face the physician-researcher.
openaire   +2 more sources

Hepatotoxicity of Tolbutamide in Dogs

Journal of the American Veterinary Medical Association, 1970
SUMMARY Three normal dogs were given sodium tolbutamide in daily oral doses of 30, 65, or 130 mg./kg.; a fourth served as the control. By day 37, the 2 that were given the larger doses became debilitated and had to be killed. They had developed hypoglycemia, degranulation of pancreatic beta cells, reduction in extractable pancreatic insulin, and ...
R B, Wilson, W D, Wilson
openaire   +2 more sources

Tolbutamide in the Treatment of Parkinsonism

JAMA, 1961
A RECENT preliminary report on the use of tolbutamide in paralysis agitans stated that 11 of 15 patients with this disorder showed considerable decrease in rigidity, tremor, or both, after the administration of this hypoglycemic agent. 1 Improvement of mask-like facies and speech was also noted in several patients. The authors found that the effect was
G L, HELLER, R N, DEJONG, K R, MAGEE
openaire   +2 more sources

Protracted tolbutamide hypoglycemia

The American Journal of Medicine, 1963
Abstract Three cases of prolonged tolbutamide-induced hypoglycemia are reported. Four additional cases, with hypoglycemia greater than twenty-four hours duration, are collected from the literature. The high mortality rate may result, in part, from clinical unfamiliarity with this complication of tolbutamide administration.
P, CUSHMAN, J J, DUBOIS, E, DWYER, J L, IZZO   +3 more
openaire   +2 more sources

Tolbutamide-induced Hemolytic Anemia

Diabetes, 1977
A 67-year-old female diabetic is presented who developed a Coombs'-positive hemolytic anemia after a year of treatment with tolbutamide. An IgG antibody was identified in the patient's serum that caused the agglutination of both the patient's red blood cells and tolbutamide-coated erythrocytes in the absence of complement. Such a reaction did not occur
P, Malacarne, G, Castaldi, M, Bertusi, G, Zavagli   +3 more
openaire   +2 more sources

TOLBUTAMIDE

The Lancet, 1971
  +7 more sources

Potentiation of Tolbutamide by Dicumarol

Annals of Internal Medicine, 1967
Excerpt The "Drug Explosion" has bred a litter of dilemmas. Simpler was life for the patient of yesteryear who was given a sugarcoated pill.
openaire   +2 more sources

TOLBUTAMIDE AND PROPRANOLOL

The Lancet, 1968
O, De Divitiis, F, Giordano, B, Gallo, A, Jacono   +3 more
openaire   +2 more sources