Results 51 to 60 of about 20,169 (222)
Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons
Frontiers in Cellular Neuroscience, 2014 Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak +6 more
doaj +1 more source
Scientific Reports, 2021 Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes.
Mohammad Nur-e-Alam +8 more
doaj +1 more source
Cisapride induced hypoglycemia via the KCNH6 potassium channel
Frontiers in Endocrinology, 2022 Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes in human and mice. Cisapride is a stomach–intestinal motility drug used to treat gastrointestinal dysfunction.
Jing Lu +7 more
doaj +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source
E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]
, 2007 Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX +21 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2482-2496, May 2026.Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng +5 more
wiley +1 more source
Post-hypoxic recovery of respiratory rhythm generation is gender dependent. [PDF]
PLoS ONE, 2013 The preBötzinger complex (preBötC) is a critical neuronal network for the generation of breathing. Lesioning the preBötC abolishes respiration, while when isolated in vitro, the preBötC continues to generate respiratory rhythmic activity.
Alfredo J Garcia +3 more
doaj +1 more source
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]
, 1990 An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi +19 more
core +1 more source