Results 51 to 60 of about 16,123 (208)
SGLT‐2 Inhibitors are Associated With a Lower Risk of Multiple Myeloma
European Journal of Haematology, Volume 117, Issue 5, Page 1347-1357, November 2026.ABSTRACT Aims We aimed to investigate drug response of sodium‐glucose transport protein‐2 inhibitors (SGLT2i) in multiple myeloma (MM), as SGLT2i have potential favorable effects on conditions related to MM. Methods We conducted a pharmacoepidemiologic study with a US nationwide health insurance claim data using Cox models to investigate the ...
Enze Liu +6 more
wiley +1 more source
Efflux Transport of Tolbutamide Across the Blood-brain Barrier
, 1998 In an attempt to determine the reason for the low brain distribution of tolbutamide, we have demonstrated the transport of tolbutamide from the brain to the blood via a non-P-glycoprotein efflux transport system which is inhibited by sulphonamides.
Hideyasu Murakami +6 more
core +1 more source
Scientific Reports, 2021 Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes.
Mohammad Nur-e-Alam +8 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago +15 more
wiley +1 more source
Cisapride induced hypoglycemia via the KCNH6 potassium channel
Frontiers in Endocrinology, 2022 Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes in human and mice. Cisapride is a stomach–intestinal motility drug used to treat gastrointestinal dysfunction.
Jing Lu +7 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley +1 more source
Effect of tolbutamide on myocardial energy metabolism
, 1983 Exposure of rat hearts perfused with 5 mM glucose and 5 mM acetate to tolbutamide led to a dramatic stimulation in glucose utilization and glycolytic flux.
S. W. Schaffer +2 more
core +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source
THE TREATMENT OF DIABETES MELLITUS WITH ORAL TOLBUTAMIDE
, 1957 Experience in the treatment of 76 diabetic patients with tolbutamide is described. In 25 patients the drug was discontinued after trials of from 1 week to several months because of poor diabetic control.
Allen Gold
core +1 more source
Annals of the New York Academy of Sciences, Volume 1563, Issue 1, September 2026.Glucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Samaneh Fatehi +2 more
wiley +1 more source