Results 51 to 60 of about 15,995 (210)
BK channels reveal novel phosphate sensitivity in SNr neurons. [PDF]
PLoS ONE, 2012 Whether large conductance Ca(2+)-activated potassium (BK) channels are present in the substantia nigra pars reticulata (SNr) is a matter of debate. Using the patch-clamp technique, we examined the functional expression of BK channels in neurons of the ...
Juan Juan Ji +9 more
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg +4 more
wiley +1 more source
Efflux Transport of Tolbutamide Across the Blood-brain Barrier
, 1998 In an attempt to determine the reason for the low brain distribution of tolbutamide, we have demonstrated the transport of tolbutamide from the brain to the blood via a non-P-glycoprotein efflux transport system which is inhibited by sulphonamides.
Hideyasu Murakami +6 more
core +1 more source
Scientific Reports, 2021 Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes.
Mohammad Nur-e-Alam +8 more
doaj +1 more source
SGLT‐2 Inhibitors are Associated With a Lower Risk of Multiple Myeloma
European Journal of Haematology, EarlyView.ABSTRACT Aims We aimed to investigate drug response of sodium‐glucose transport protein‐2 inhibitors (SGLT2i) in multiple myeloma (MM), as SGLT2i have potential favorable effects on conditions related to MM. Methods We conducted a pharmacoepidemiologic study with a US nationwide health insurance claim data using Cox models to investigate the ...
Enze Liu +6 more
wiley +1 more source
Cisapride induced hypoglycemia via the KCNH6 potassium channel
Frontiers in Endocrinology, 2022 Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes in human and mice. Cisapride is a stomach–intestinal motility drug used to treat gastrointestinal dysfunction.
Jing Lu +7 more
doaj +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2682-2692, August 2026.Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
wiley +1 more source
Effect of tolbutamide on myocardial energy metabolism
, 1983 Exposure of rat hearts perfused with 5 mM glucose and 5 mM acetate to tolbutamide led to a dramatic stimulation in glucose utilization and glycolytic flux.
S. W. Schaffer +2 more
core +1 more source
Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K+ channels from pancreatic B-cells [PDF]
, 1988 The effects of intracellular purine nucleotides on tolbutamide-induced block of ATP-dependent K+ channels from mouse pancreatic B-cells were studied using the patch-clamp technique.
G. Trube +9 more
core +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source