Results 31 to 40 of about 16,123 (208)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

PLoS Biology, 2007
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta ...
Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman   +8 more
doaj   +1 more source

KATP Channels Mediate Differential Metabolic Responses to Glucose Shortage of the Dorsomedial and Ventrolateral Oscillators in the Central Clock

Scientific Reports, 2017
The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP ...
Jyh-Jeen Yang, Ruo-Ciao Cheng, Pi-Cheng Cheng, Yi-Chi Wang, Rong-Chi Huang   +4 more
doaj   +1 more source

Effect of tolbutamide on plasma renin activity.

, 1979
The effect of tolbutamide on renin secretion in rats was studied in vivo, and in vitro. Administration of tolbutamide in doses of 12.5 and 25 mg/kg body wt ip to two groups of rats produced no significant change in plasma renin activity compared to the ...
N K Sherma, D R Rovner, V V Gossain, A M Michelakis   +3 more
core   +1 more source

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

Acta Pharmaceutica Sinica B, 2022
Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of influence on animal longevity.
Zhifan Mao, Wenwen Liu, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu, Jian Li   +8 more
doaj   +1 more source

BINDING OF TOLBUTAMIDE TO GLYCATED HUMAN SERUM ALBUMIN [PDF]

, 2011
The presence of elevated levels of glucose in blood during diabetes can lead to the non-enzymatic glycation of serum proteins such as human serum albumin (HSA). This study examined the changes that occur in binding of the sulfonylurea drug tolbutamide to
David S. Hage, Joseph, K.S., Hage, David S., Jeanethe Anguizola, K.S. Joseph, Anguizola, Jeanethe   +5 more
core   +1 more source

Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats

Brazilian Journal of Medical and Biological Research, 2005
We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid
A.R.A. Rodrigues, M.S.A. Castro, J.N. Francischi, A.C. Perez, I.D.G. Duarte   +4 more
doaj   +1 more source

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo.
Yiping Lin, Yanli Wei, Xiaoxia Hu, Mei-Ling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, Liman Qiao   +8 more
doaj   +1 more source

Hypoglycaemic agents: variants of tolbutamide

, 1964
Further new variants of tolbutamide (and two new imidazolines) are described.
V Petrow, D F Hayman, A M Wild, G B Jackman, O Stephenson   +4 more
core   +1 more source

Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera, Francesco Basoccu, Andrea Porcheddu   +2 more
wiley   +2 more sources

Synthesis and characterization of tolbutamide–molybdenum complex by thermal, spectral and X-ray studies

Journal of Saudi Chemical Society, 2010
Synthesis and characterization of molybdenum complex with tolbutamide (an oral antidiabetic drug) have been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of L2M type.
S. A. Iqbal, George Jacob, I. Zaafarany
doaj   +1 more source