Results 31 to 40 of about 20,169 (222)

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

PLoS Biology, 2007
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta ...
Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman   +8 more
doaj   +1 more source

Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]

, 2016
open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon, Angelo Avogaro, Camilla Luni, Catalin Dacian Ciubotaru, Fabio Mammano, Gian Paolo Fadini, Nicola Elvassore, Onelia Gagliano, Silvia Galvanin, Valentina Scattolini   +9 more
core   +2 more sources

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]

, 2016
Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I., Elhachmane, M., Gopel, S., Pedersen, MORTEN GRAM   +3 more
core   +1 more source

KATP Channels Mediate Differential Metabolic Responses to Glucose Shortage of the Dorsomedial and Ventrolateral Oscillators in the Central Clock

Scientific Reports, 2017
The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP ...
Jyh-Jeen Yang, Ruo-Ciao Cheng, Pi-Cheng Cheng, Yi-Chi Wang, Rong-Chi Huang   +4 more
doaj   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
core   +1 more source

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo.
Yiping Lin, Yanli Wei, Xiaoxia Hu, Mei-Ling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, Liman Qiao   +8 more
doaj   +1 more source

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

Acta Pharmaceutica Sinica B, 2022
Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of influence on animal longevity.
Zhifan Mao, Wenwen Liu, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu, Jian Li   +8 more
doaj   +1 more source

Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats

Brazilian Journal of Medical and Biological Research, 2005
We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid
A.R.A. Rodrigues, M.S.A. Castro, J.N. Francischi, A.C. Perez, I.D.G. Duarte   +4 more
doaj   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor I. Binding characteristics [PDF]

, 1994
Glimepiride is a novel sulfonylurea drug for treatment of non-insulin-dependent diabetes mellitus with higher blood sugar lowering efficacy in diabetic patients than glibenclamide raising the question whether this characteristics is in line with ...
Aguilar-Bryan, Ashcroft, Ashcroft, Benovic, Bhathena, Boyd, Boyd, Boyd, Carpentier, Chick, French, Gaines, Geisen, Geisen, Gerich, Gylfe, Kaubisch, Kolterman, Kramer, Kramer, Müller, Nelson, Nelson, Niki, Niki, Niki, Niki, Panten, Popov, Praz, Schmid-Antomarchi, Schmid-Antomarchi, Sturgess, Sugiura, Weiland, Yalow   +35 more
core   +1 more source