Results 31 to 40 of about 13,288 (170)

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo.
Yiping Lin, Yanli Wei, Xiaoxia Hu, Mei-Ling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, Liman Qiao   +8 more
doaj   +1 more source

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

Acta Pharmaceutica Sinica B, 2022
Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of influence on animal longevity.
Zhifan Mao, Wenwen Liu, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu, Jian Li   +8 more
doaj   +1 more source

Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats

Brazilian Journal of Medical and Biological Research, 2005
We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid
A.R.A. Rodrigues, M.S.A. Castro, J.N. Francischi, A.C. Perez, I.D.G. Duarte   +4 more
doaj   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Synthesis and characterization of tolbutamide–molybdenum complex by thermal, spectral and X-ray studies

Journal of Saudi Chemical Society, 2010
Synthesis and characterization of molybdenum complex with tolbutamide (an oral antidiabetic drug) have been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of L2M type.
S. A. Iqbal, George Jacob, I. Zaafarany
doaj   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Frontiers in Pharmacology, 2022
Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in ...
Yawen Yuan, Yawen Yuan, Qingfeng He, Shunguo Zhang, Min Li, Zhijia Tang, Xiao Zhu, Zheng Jiao, Weimin Cai, Xiaoqiang Xiang   +9 more
doaj   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

An antioxidant activity of Cinnamonum tamala improves histopathological alterations and biochemical parameters in alloxan induced diabetic rats

Asian Journal of Medical Sciences, 2019
Background: Diabetic mellitus is a multifactorial disorder associated with its devastating consequences has assumed epidemic proportion. Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the
Mamata Laxmikant Pochhi
doaj   +1 more source

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

Integrative Medicine Research, 2017
Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and ...
Manodeep Chakraborty, Mohammed Gulzar Ahmed, Ananya Bhattacharjee   +2 more
doaj   +1 more source

Natural products embedded crown ethers as potent insulin secretory agents

Pakistan Journal of Pharmaceutical Sciences, 2021
Natural products embedded crown ethers were prepared by utilizing bioactive natural products including chrysin, tetrahydroisoquinoline (THIQ), and biochanin-A.
Nuzhat Arshad, Abdul Hameed, Jamshed Hashim, Tahseen Iqbal, Iqra Munir, Syed Abid Ali, Maha Sharif, Deedar Ali, Shumaila Javed, Rahman M Hafizur   +9 more
doaj   +1 more source