Results 21 to 30 of about 15,995 (210)
Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria [PDF]
, 1973 1973-031. The effect of tolbutamide on the oxidation rate, respiratory control index and P/0 ratio of intact rat liver mitochondria was studied. 2. Addition of more than 30 mg% tolbutamide apparently increased the state 4 respiration rate and decreased ...
KATSUMATA, KAZUO, HAGIHARA, MASAKO
core +1 more source
Zagazig Journal of Pharmaceutical Sciences, 1997 A perfusion system was conducted for more than 6 hours in response to glucose (16.7mM), theophylline (5 mM ) and tolbutamide (100 µg/ml) to give an insight about the B-cell secretory capacity. Continuous exposure of the isolated pancreas to glucose (16.7
Hassan El-Fayoumi
doaj +1 more source
Development and Structural Characterization of UTE-156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase. [PDF]
Adv Sci (Weinh)The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Tamayo-Jaramillo D +8 more
europepmc +2 more sources
Xiao chai hu tang for liver diseases: A literature review
World Journal of Traditional Chinese Medicine, 2017 The objective of this study is to summarize the pharmacological effects and the mechanisms of action of Xiao Chai Hu Tang (XCHT, Minor Bupleurum Decoction) on liver diseases, so as to give relevant researchers a valuable insight and benefit patients with
Yi Wang +3 more
doaj +1 more source
Within-Sulfonylurea-Class Evaluation of Time to Intensification with Insulin (ZODIAC-43). [PDF]
PLoS ONE, 2016 Previous studies have shown that many within-class differences exist between sulfonylureas (SUs), however, whether differences exist regarding the time it takes between initiating an SU and the need to intensify treatment with insulin is unclear. The aim
Dennis Schrijnders +5 more
doaj +1 more source
Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala +3 more
doaj +1 more source
Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2016 PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity
Toshiro Niwa, Yurie Imagawa
doaj +1 more source
Molecules, 2017 Shenxiong glucose injection (SGI), a traditional Chinese medicine (TCM) preparation, has been widely used for the treatment of various cardiovascular and cerebrovascular diseases for many years.
Jia Sun +11 more
doaj +1 more source
PLoS Biology, 2007 Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta ...
Patrick E MacDonald +8 more
doaj +1 more source