Results 21 to 30 of about 13,288 (170)
Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala +3 more
doaj +1 more source
Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin
Molecules, 2017 Glycation process occurs in protein and becomes more pronounced in diabetes when an increased amount of reducing sugar is present in bloodstream. Glycation of protein may cause conformational changes resulting in the alterations of its binding properties
Agnieszka Szkudlarek +4 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2016 PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity
Toshiro Niwa, Yurie Imagawa
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Host-Guest Chemistry of Tolbutamide
Molecules, 2006 The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search.
Rosa M. Claramunt +2 more
doaj +1 more source
Molecules, 2017 Shenxiong glucose injection (SGI), a traditional Chinese medicine (TCM) preparation, has been widely used for the treatment of various cardiovascular and cerebrovascular diseases for many years.
Jia Sun +11 more
doaj +1 more source
Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera +2 more
wiley +2 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
PLoS Biology, 2007 Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring beta ...
Patrick E MacDonald +8 more
doaj +1 more source
Scientific Reports, 2017 The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP ...
Jyh-Jeen Yang +4 more
doaj +1 more source