Acta Pharmaceutica Sinica B, 2022 Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of influence on animal longevity.
Zhifan Mao, Wenwen Liu, Yunyuan Huang
exaly +3 more sources
Catching new modulated high-pressure phases of δ-chlorpropamide: when the experimental setup matters [PDF]
IUCrJThe antidiabetic drug chlorpropamide [1-(4-chlorophenyl)sulfonyl-3-propylurea, CPA] has one of the highest numbers of reported polymorphs, making it an excellent model system for studying structural responses to pressure or temperature.
Nikita E. Bogdanov +4 more
doaj +2 more sources
Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Lepr db mice [PDF]
BMC Complementary Medicine and Therapies, 2022 Background Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells.
N. M. Mkolo +5 more
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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets [PDF]
Frontiers in ImmunologyBackgroundType 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction.
Huahua Li +4 more
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Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs [PDF]
Genes and EnvironmentBackground Previously, Japanese Environmental Mutagen and Genome Society/Mammalian Mutagenicity Study Group/Toxicogenomics Study Group (JEMS/MMS toxicogenomic study group) proposed 12 genotoxic marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15 ...
Chie Furihata, Takayoshi Suzuki
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Chlorpropamide-alcohol flushing and plasma chlorpropamide concentrations in diabetic patients on maintenance chlorpropamide therapy [PDF]
Diabetologia, 1983 Forty-three diabetic patients on maintenance chlorpropamide (100-750 mg daily) drank 0.2 ml/kg 90% ethanol after equilibration in a room controlled at 20 degrees C. Twenty-five patients had already noted marked alcohol flushing since starting chlorpropamide therapy (group A), while 13 had not observed this (group B).
R M, Hillson +4 more
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Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility
Pharmaceuticals, 2022 The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API ...
Mafalda C. Sarraguça +3 more
doaj +1 more source
Heliyon, 2021 Introduction: Increase in the prevalence of type-2 diabetes in Sub-Sahara Africa has created the need for robust treatment and management programs. However, an effective diabetes management program requires a high annual budget that most countries in ...
Isaac Kyei-Barffour +8 more
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Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala +3 more
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Halogen Bonding in Sulphonamide Co-Crystals: X···π Preferred over X···O/N?
Molecules, 2023 Sulphonamides have been one of the major pharmaceutical compound classes since their introduction in the 1930s. Co-crystallisation of sulphonamides with halogen bonding (XB) might lead to a new class of pharmaceutical-relevant co-crystals. We present the
Tobias Heinen +3 more
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