Results 11 to 20 of about 3,073 (184)

Antidiabetic effect of chloroform - methanol extract of Abrus precatorius linn seed in alloxan diabetic rabbit

Journal of Applied Sciences and Environmental Management, 2005
The antidiabetic effect of chloroform-methanol extract of Abrus precatorious seed, was studied in alloxan diabetic rabbits. The effect was compared to that of chlorpropamide - a known antidiabetic drug in the class of sulphonylurea and a control group ...
CC Monago, EO Alumanah
doaj   +2 more sources

Form (III) of artemisinin: discovery and crystallographic characterization of a new high-pressure polymorph. [PDF]

Acta Crystallogr B Struct Sci Cryst Eng Mater
The polymorphic behaviour of the three forms of artemisinin was investigated using single‐crystal X‐ray diffraction in a diamond anvil cell, with notable observation of a pressure‐induced phase transition from form (II) to form (III).Artemisinin (ART) is mainly used for the treatment of malaria and exhibits polymorphism with two known crystalline forms.
Fetah B, Connor LE, Warren MR, Doherty CL, Oswald IDH.   +4 more
europepmc   +2 more sources

Two Patients With Extremely Long Type 1 Diabetes Duration With Very Few Complications and Remaining Insulin Secretion. [PDF]

Clin Case Rep
ABSTRACT We present two patients with > 80 years with type 1 diabetes (T1D), but with minor complications. Their history and risk factors are characterized as are factors conferring resilience against angiopathy. Amazingly, both had clearly detectable C‐peptide.
Sjöholm Å, Espes D.
europepmc   +2 more sources

Conformational polymorphism of the antidiabetic drug chlorpropamide [PDF]

, 2011
In this paper, the main features of Raman spectroscopy, one of the first choice methods in the study of polymorphism in pharmaceuticals, are presented taking chlorpropamide as a case of study.
Mendes Filho, J., Martins, F. T., J. Ellena, S. N. Faudone, F. T. Martins, S. L. Cuffini, C. C. P. da Silva, M. W. C. Caetano, S. B. Honorato, J. Mendes Filho, Cuffini, Silvia Lucia, Da Silva, C. C. P., Ayala, A. P., Caetano, M. W. C., Honorato, S. B., Ellena, J., Faudone, Sonia Nerina, A. P. Ayala, Siesler, H. W., H. W. Siesler   +19 more
core   +2 more sources

Simultaneous Quantification of Antidiabetic Agents in Human Plasma by a UPLC-QToF-MS Method. [PDF]

PLoS ONE, 2016
An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the simultaneous quantification of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and ...
Mariana Millan Fachi, Letícia Bonancio Cerqueira, Letícia Paula Leonart, Thais Martins Guimarães de Francisco, Roberto Pontarolo   +4 more
doaj   +1 more source

A Sensitive, Simple, and Fast LC–MS/MS Method for Quantification of Remifentanil in Human Plasma: Applications in Critically Ill Patients’ Plasma during Extracorporeal Membrane Oxygenation

Separations, 2023
A sensitive, simple, and fast liquid chromatography–tandem mass spectrometry (LC–MS/MS) bioanalytical method was developed to determine remifentanil in human plasma and prevent its instability by esterases during quantification.
Soon Uk Chae, Ji Seon Kim, Chae Bin Lee, Seong Jun Jo, Kyung Lok Min, Min Jung Chang, Soo Kyung Bae   +6 more
doaj   +1 more source

Roux-en-Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice. [PDF]

Physiol Rep
Abstract The impact of Roux‐en‐Y gastric bypass (RYGB) on indole metabolism and AhR signaling is poorly understood. Therefore, we tested the hypothesis that RYGB changes the indole metabolite profile in the gut, leading to changes in AhR signaling. To test this hypothesis, we developed a mouse model of RYGB that recapitulates the human procedure. Given
Wang A, Agabao-Tucker ME, Goodson ML, Ehrlich AK, Cummings BP.   +4 more
europepmc   +2 more sources

Identification of free radicals formed in gamma-irradiated chlorpropamide and procainamide hydrochloride pharmaceutical raw materials by EPR spectroscopy [PDF]

, 2023
In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic ...
Osmanoğlu, Yunus Emre, Sütçü, Kerem
core   +1 more source

The Role of Vasopressin V2 Receptor in Drug-Induced Hyponatremia

Frontiers in Physiology, 2021
Hyponatremia is frequently encountered in clinical practice and usually induced by renal water retention. Many medications are considered to be among the various causes of hyponatremia, because they either stimulate the release of arginine vasopressin ...
Sua Kim, Chor Ho Jo, Gheun-Ho Kim, Gheun-Ho Kim   +3 more
doaj   +1 more source

Where do sulphonylureas fit in the type 2 diabetes guidelines?

South African Family Practice, 2014
Sulphonylureas act by binding to sulphonylurea receptors and stimulating insulin secretion from pancreatic beta cells. This class of oral hypoglycaemic agents is still widely used in the management of type 2 diabetes in patients where lifestyle changes ...
Gail Mkele
doaj   +1 more source