Results 51 to 60 of about 190,214 (268)

Identification and validation of parthanatos-related genes in end-stage renal disease

Renal Failure
Background End-Stage Renal Disease (ESRD) is a severe chronic kidney disease with a rising global incidence, often accompanied by various complications, severely impacting patients’ quality of life. Parthanatos plays a crucial role in the pathogenesis of
Xuan Dai, Lianfang Yuan
doaj   +1 more source

Contribution of us and ct for diagnosis of intra peritoneal focal fat infarction (iffi): a pictorial review

Journal of the Belgian Society of Radiology, 2010
The term IFFI – for Intraperitoneal Focal Fat Infarction – includes various acute abdominal clinical conditions in which focal fatty tissue necrosis represents the common pathologic denominator.
B Coulier
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Acute abdomen presentation in dengue fever during recent outbreak

Journal of Acute Disease, 2017
Objective: To evaluate the etiology, clinical profile and outcome of acute abdomen presentation in Dengue Fever (DF).Methods: This clinical prospective study was done on confirmed cases of DF admitted in the department of medicine during recent epidemic (
Bal Kishan Gupta, Hardeva Ram Nehara, Sahil Parmar, Shyam Lal Meena, Suresh Gajraj, Jigyasa Gupta   +5 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Case Report: Beyond the monophasic myth: relapsing Baló’s concentric sclerosis with residual disability

Frontiers in Human Neuroscience
BackgroundBaló’s concentric sclerosis (BCS) is a rare demyelinating disorder with a striking radiological signature. Its potential for relapse and the impact of vascular comorbidities on disease course remains underrecognized.Case presentationA 52-year ...
Weiya Li, Weiya Li, Weiya Li, Weiya Li, Weiya Li, Zhao Jin, Chensijia Zhang, Lele Wang, Mengyi Zhao, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Qian Li, Qian Li, Qian Li, Qian Li, Qian Li   +20 more
doaj   +1 more source

Acute Surgical Abdomen

Journal of Investigative Medicine High Impact Case Reports, 2014
Background . Pulmonary embolism is a common and potentially lethal condition. Most patients who die from massive pulmonary embolism do so within the first few hours of the event.
Nader AL-Mane LRCP & SI MB BCh NUI FCARCSI, Faisal AL-Mane MB BCh MRCPI FRCPC, Zein Abdalla MB BS MS FRCA, Joe McDonnell MB BCh FFARCSI   +3 more
doaj   +1 more source

Hypothermia and the acute abdomen [PDF]

BMJ Case Reports, 2014
A 64-year old man presented to A&E with a 24 h history of persistent hypothermia and increasing confusion. His medical history included congestive heart failure, hypertension and intermittent claudication secondary to distal abdominal aortic occlusion. Examination revealed profound hypothermia—31°C, bilateral reduced power in the lower limbs and no
openaire   +2 more sources

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source