Results 81 to 90 of about 3,350,942 (312)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Imaging Findings of Gastrointestinal Emergency in Infants and Young Children
대한영상의학회지, 2020 Acute abdomen is a condition with sudden abdominal pain that may require immediate surgical treatment. The causes of acute abdomen in pediatric patients are diverse, and can be categorized in broad range from diseases requiring surgery to diseases ...
Ji Young Kim
doaj +1 more source
Epiploic Appendagitis: An Often Misdiagnosed Cause of Acute Abdomen
Case Reports in Gastroenterology, 2019 Epiploic appendages are peritoneal structures that arise from the outer serosal surface of the bowel wall towards the peritoneal pouch. They are filled with adipose tissue and contain a vascular stalk. Epiploic appendagitis is a rare cause of acute lower
V. C. Suresh Kumar +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Identification and validation of parthanatos-related genes in end-stage renal disease
Renal FailureBackground End-Stage Renal Disease (ESRD) is a severe chronic kidney disease with a rising global incidence, often accompanied by various complications, severely impacting patients’ quality of life. Parthanatos plays a crucial role in the pathogenesis of
Xuan Dai, Lianfang Yuan
doaj +1 more source
Journal of the Belgian Society of Radiology, 2010 The term IFFI – for Intraperitoneal Focal Fat Infarction – includes various acute abdominal clinical conditions in which focal fatty tissue necrosis represents the common pathologic denominator.
B Coulier
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Acute abdomen presentation in dengue fever during recent outbreak
Journal of Acute Disease, 2017 Objective: To evaluate the etiology, clinical profile and outcome of acute abdomen presentation in Dengue Fever (DF).Methods: This clinical prospective study was done on confirmed cases of DF admitted in the department of medicine during recent epidemic (
Bal Kishan Gupta +5 more
doaj +1 more source
S1589 A Rare Manifestation of COVID-19 in the Abdomen: Acute Pancreatitis
American Journal of Gastroenterology, 2021 S. Naz +9 more
semanticscholar +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source