Results 51 to 60 of about 11,238 (184)

Nanoparticles Effectively Target Rapamycin Delivery to Sites of Experimental Aortic Aneurysm in Rats. [PDF]

PLoS ONE, 2016
Several drugs targeting the pathogenesis of aortic aneurysm have shown efficacy in model systems but not in clinical trials, potentially owing to the lack of targeted drug delivery.
Takuro Shirasu, Hiroyuki Koyama, Yutaka Miura, Katsuyuki Hoshina, Kazunori Kataoka, Toshiaki Watanabe   +5 more
doaj   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Delayed Manifestations of a Case of Blunt Chest Wall Trauma‐Induced Pseudoaneurysm of the Mitral‐Aortic Intervalvular Fibrosa: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Pseudoaneurysm of the mitral‐aortic intervalvular fibrosa (P‐MAIVF) is a rare condition resulting from dehiscence of the mitral‐aortic intervalvular fibrosa (MAIVF), leading to the formation of a sac communicating with the left ventricular outflow tract (LVOT).
Alisina Mirzaei, Armin Attar, Alireza Moaref, Ahmad Ali Amirghofran   +3 more
wiley   +1 more source

Spatial and single‐cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
This study has used integrated single‐cell RNA sequencing and Visium HD spatial transcriptomics to construct a high‐resolution immune cell atlas of human ascending thoracic aortic aneurysms (ATAA). The analysis reveals distinct immune cell composition and interactions in ATAA tissues, providing new insights into immune dysregulation and vascular ...
Ke Zhen, Zhiyong Du, Pengcheng Wang, Song Liu, Junming Zhu, Zhiyu Qiao, Hongfeng Jiang   +6 more
wiley   +1 more source

Developing and Assessing the Acceptability of an Information Booklet for Patients in Surveillance for Abdominal Aortic Aneurysms: An Intervention Development Study

Health Expectations, Volume 29, Issue 2, April 2026.
ABSTRACT Background In the United Kingdom and Sweden, men aged 65 are offered screening for Abdominal Aortic Aneurysm (AAA). Men with small AAA enter a surveillance programme to monitor growth until the AAA is large enough for referral for treatment. Some men develop anxiety related to having an AAA or being in surveillance. Aim The original aim was to
Cheryl Grindell, Jane Hughes, Elizabeth Lumley, Alan Elstone, Jo Hall, Jonathan Michaels, Akhtar Nasim, Stephen Radley, Phil Shackley, Niall MacGregor Smith, Gerry Stansby, Emily Wood, Alicia O'Cathain   +12 more
wiley   +1 more source

Using Patient-Based Computational Fluid Dynamics for Abdominal Aortic Aneurysm Assessment

Bioengineering
Abdominal aortic aneurysm (AAA) is a dangerous disease and can cause sudden death if it ruptures. This study investigated blood flow behaviors and hemodynamic changes in three categories (small, medium and large diameters) of AAAs using computational ...
Natthaporn Kaewchoothong, Sorracha Rookkapan, Chayut Nuntadusit, Surapong Chatpun   +3 more
doaj   +1 more source

IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

Nature Communications, 2019
Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature ...
Iuliia O. Peshkova, Turan Aghayev, Aliia R. Fatkhullina, Petr Makhov, Elizaveta K. Titerina, Satoru Eguchi, Yin Fei Tan, Andrew V. Kossenkov, Marina V. Khoreva, Lyudmila V. Gankovskaya, Stephen M. Sykes, Ekaterina K. Koltsova   +11 more
doaj   +1 more source

Short Leukocyte Telomere Length is Associated with Abdominal Aortic Aneurysm (AAA) [PDF]

European Journal of Vascular and Endovascular Surgery, 2010
Telomeres are specialised DNA structures present at the ends of linear chromosomes, which shorten with each successive cell division and the length of which represents cellular biological age. The aim of this study was to determine the relationship between abdominal aortic aneurysm (AAA) and white cell telomere length.Peripheral blood samples were ...
Atturu, G, Brouilette, S, Samani, NJ, London, NJ, Sayers, RD, Bown, MJ   +5 more
openaire   +3 more sources

Circulating elastin crosslinking desmosines are associated with arterial wall degradation in older adults with atherosclerosis

Physiological Reports, Volume 14, Issue 7, April 2026.
Circulating desmosines may reflect arterial wall degeneration associated with atherosclerotic disease. Abstract Elastin, an extracellular matrix component that contributes to vascular integrity, is progressively degraded during vascular injury including atherosclerosis.
Hana Inoue, Lisa Takahashi, Hirofumi Tomiyama, Arisa Araki, Toshitaka Nagao, Taishiro Chikamori, Toyonobu Usuki, Utako Yokoyama   +7 more
wiley   +1 more source

Simple renal cysts and bovine aortic arch: markers for aortic disease

Open Heart, 2019
Objective This study aimed to assess the prevalence of thoracic aortic disease (TAD) and abdominal aortic aneurysms (AAA) among patients with simple renal cyst (SRC) and bovine aortic arch (BAA).Methods Through a retrospective search for patients who ...
Adam J Brownstein, Syed Usman Bin Mahmood, Ayman Saeyeldin, Camilo Velasquez Mejia, Mohammad A Zafar, Yupeng Li, John A Rizzo, Neera K Dahl, Young Erben, Bulat A Ziganshin, John A Elefteriades   +10 more
doaj   +1 more source