Results 71 to 80 of about 145,347 (298)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Is Cerebroplacental Ratio A Marker of Impaired Fetal Growth Velocity and Adverse Pregnancy Outcome? [PDF]

, 2016
BACKGROUND: The cerebroplacental ratio has been proposed as a marker of failure to reach growth potential near term. Low cerebroplacental ratio, regardless of the fetal size, is independently associated with the need for operative delivery for presumed ...
Acharya, Amar Bhide, Amer-Wahlin, Arias, Aris Papageorghiou, Asma Khalil, Bahado-Singh, Bahlmann, Baschat, Basky Thilaganathan, Bricker, Buck Louis, Bukowski, Callec, Chang, Cruz-Martinez, de Jong, Deter, DeVore, Ebrashy, Flood, Flood, Gardosi, Gardosi, Gordijn, Gramellini, Hadlock, Iraola, José Morales-Rosello, Khalil, Khalil, Khalil, Makhseed, McIntyre, Mintu Nath, Morales-Roselló, Morales-Roselló, Naila Khan, Nassr, Ogasawara, Pasupathy, Pilliod, Prior, Priya Agarwal, Regan, Robinson, Romero, Sjaarda, Snijders, Souka, Sovio, Vayssière, Yudkin   +52 more
core   +2 more sources

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Prevalence and five-year cumulative incidence of abdominal obesity in Croatian women of childbearing age: the CroHort study [Prevalencija i petogodišnja kumulativna incidencija abdominalne pretilosti u žena fertilne dobi u Hrvatskoj] [PDF]

, 2012
Generalised obesity is increasing in prevalence globally, however trends in abdominal obesity are less well known. In 2003, 1,999 women of childbearing age participated in the Croatian Adult Health Survey, of whom 598 (29.9%) participated in the second ...
Fišter, Kristina, Ivanković, Davor, Kern, Josipa, Koršić, Mirko, Musić Milanović, Sanja, Pavleković, Gordana, Vuletić, Silvije   +6 more
core  

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source

The Finnish Diabetes Risk Score (FINDRISC) and increased body weight

Journal of Medical Science, 2016
Introduction. The Finnish Diabetes Risk Score (FINDRISC) assesses the 10-year type 2 diabetes risk in adults by identifying individuals with overweight or obesity, inadequate physical activity, poor nutrition, or a family or personal history of ...
Joanna Pekar, Rafał Mazur, Małgorzata Kozilewicz, Aleksandra Jóźwiak, Anna Olszewska, Katarzyna Skórzyńska-Dziduszko   +5 more
doaj   +1 more source

A Microfiber‐Reinforced Janus Hydrogel E‐Skin With Recyclable Feature for Multimodal Sensing and Gender‐Specific Physiological Monitoring

Advanced Science, EarlyView.
Hydrogel‐based wearable electronics hold great promise for physiological monitoring in privacy‐sensitive regions. In this study, a polyurethane (PU) microfiber‐reinforced gelatin hydrogel e‐skin is developed, boasting multiple advantages such as ultra‐thinness, high toughness, and long‐term skin conformability.
Yarong Ding, Yufeng Li, Shaozhe Tan, Jiachun Sun, Xu Yang, Xuesi Zhang, Zhenhua Lin, Zhenyu Li, Yue Hao, Yannan Liu, Yingchun Li, Jingjing Chang   +11 more
wiley   +1 more source

Effect of Abdominal Circumference and Fetal Weight on Supine Hypotension during C-Section under Spinal Anesthesia

Pakistan Journal of Medical Research
Background: Spinal anesthesia is the safest and most popular technique used for cesarean section worldwide. Certain maternal and fetal conditions such as increased maternal abdominal circumference and fetal weight can have profound effect on degree of ...
Hubba Ahmed, Zaira Batool, Shaista Rashid, Ashok Perchani, Farjad Sultan   +4 more
doaj   +4 more sources

Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study [PDF]

, 2009
OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications.
Booth, Sarah L., Cheng, Susan, Fox, Caroline S., Hoffmann, Udo, Jacques, Paul F., Keyes, Michelle J., Larson, Martin G., Massaro, Joseph M., McCabe, Elizabeth L., O'Donnell, Christopher J., Robins, Sander J., Vasan, Ramachandran S., Wang, Thomas J., Wolf, Myles   +13 more
core   +3 more sources