Results 61 to 70 of about 1,075,356 (291)

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women [PDF]

, 2013
01.04.14 KB.
Chowienczyk, P, Direk, K, Astle, W, Falchi, M, Tim D Spector, Toby Andrew, Cecelja, M, Chowienczyk, Phil, Andrew, T, Astle, William, Mario Falchi, Phil Chowienczyk, Spector, TD, William Astle, Direk, Kenan, Spector, Tim D, Falchi, Mario; id_orcid, Andrew, Toby, Marina Cecelja, Kenan Direk, Cecelja, Marina   +20 more
core   +3 more sources

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

The landscape of the long non-coding RNAs and circular RNAs of the abdominal fat tissues in the chicken lines divergently selected for fatness

BMC Genomics, 2022
Background Excessive deposition of abdominal fat poses serious problems in broilers owing to rapid growth. Recently, the evolution of the existing knowledge on long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have established their ...
Yang Jing, Bohan Cheng, Haoyu Wang, Xue Bai, Qi Zhang, Ning Wang, Hui Li, Shouzhi Wang   +7 more
doaj   +1 more source

Influence of different fat emulsions with 10 or 20% MCT/LCT or LCT on lipoproteins in plasma of patients after abdominal surgery [PDF]

, 1998
In patients after elective abdominal surgery, different fat emulsions were used to compare their efficacy in total parenteral nutrition and in normalizing plasma lipoprotein levels.
Jauch, Karl-Walter, Wolfram, Günther, Hailer, Susanne, Hailer, Susanne;Jauch, Karl-Walter;Wolfram, Günther   +3 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Abdominal visceral to subcutaneous fat distribution in dogs: computed tomography accuracy and factors associated with distribution

BMC Veterinary Research
Background Abdominal fat distribution, particularly visceral fat, is commonly assessed as a marker of obesity-related and metabolic diseases in people.
Robert B. S. Turner, S. M. Firestone, F. R. Dunshea, C. S. Mansfield   +3 more
doaj   +1 more source

Effects of High-fat Diet on Alternative Splicing of RNA in Abdominal Fat and Liver Tissues of Broilers

Guangdong nongye kexue
【Objective】Excessive deposition of abdominal fat reduces disease resistance and slaughter rate of broilers. RNA alternative splicing is an important regulatory modality that affects gene function.
Guangyu AO, Genghua CHEN, Yilin XIA, Wen LUO   +3 more
doaj   +1 more source

Dietary fat intake and obesity : an empirical study in Greek adults. [PDF]

The empirical evidence concerning the associations between diet, particularly fat intake, and obesity is inconclusive. The aim of the present study was to investigate cross-sectional associations between general and central ...
Lagiou, Areti
core   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source