Results 171 to 180 of about 149,144 (263)

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Minimally invasive approaches for thoracoabdominal injuries. [PDF]

Kardiochir Torakochirurgia Pol
Khodjimatov GM, Yahyoev SMO.
europepmc   +1 more source

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

Extended Focused Assessment with Sonography for Trauma in the Emergency Department: A Comprehensive Review. [PDF]

J Clin Med
Bella FM, Bonfichi A, Esposito C, Zanza C, Bellou A, Sfondrini D, Voza A, Piccioni A, Di Sabatino A, Savioli G.   +9 more
europepmc   +1 more source

Consensus‐Based Recommendations for Yoga as Adjunct Therapy in Eating Disorder Treatment: A Delphi Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study aimed to develop consensus‐based statements, combining the expertise of eating disorder (ED) clinicians and yoga instructors, on key considerations for applying yoga for individuals with anorexia nervosa, bulimia nervosa, and binge‐eating disorder.
Eleanor Trethewey, Subhadra Evans, Shane McIver, Michael de Manincor, Janani Janakiraman, Arvind V. Iyer, Melissa O'Shea   +6 more
wiley   +1 more source

Abbreviated injury scale-guided assessment of traumatic deaths: postmortem CT versus autopsy. [PDF]

Forensic Sci Int Synerg
Likkachai K, Wongwaisayawan S, Siriwes K, Worasuwannarak W.   +3 more
europepmc   +1 more source

Self‐Disgust, Body‐Related Attentional Bias and Body Dissatisfaction: A Virtual Reality and Eye‐Tracking Exploration

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examines the relationships between self‐disgust, body dissatisfaction (BD), and attentional biases (AB) toward weight‐related body areas, exploring whether self‐disgust predicts attentional avoidance and moderates the relationship between BD and AB.
Mariarca Ascione, Klaske A. Glashouwer, Franck‐Alexandre Meschberger‐Annweiler, María Teresa Mendoza‐Medialdea, Bruno Porras‐Garcia, Marta Ferrer‐Garcia, José Gutierrez‐Maldonado   +6 more
wiley   +1 more source

Future directions in the treatment of pelvic fractures with abdominal organ injury: the potential of combined endovascular embolization and external fixation techniques. [PDF]

Front Med (Lausanne)
Ma G, Di Z, Wen Y, Zhang C, Hao H, Li Y, Zhang Y.   +6 more
europepmc   +1 more source

Pancreas-Specific Physical Examination Enabling Early Diagnosis of Pancreatic Injury in Children: A Case Report. [PDF]

Cureus
Ihara T, Nomura O, Ishikawa M, Shimotakahara A, Shimojima N, Mori T.   +5 more
europepmc   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source