Results 111 to 120 of about 997,879 (304)

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Trends in obesity and abdominal obesity in the older adult population of Spain (2000-2010) [PDF]

, 2013
Objective: This work examines the trend in obesity and abdominal obesity in the Spanish population aged 60 years and over during the first decade of the 21st century.
Banegas Banegas, José Ramón, Regidor, Enrique, Rodríguez Artalejo, Fernando, Enrique Regidor, Juan Luis Gutiérrez-Fisac, León-Muñoz, Luz María, JoséR. Banegas, Fernando Rodríguez-Artalejo, Luz M. León-Muñoz, Gutiérrez-Fisac, Juan Luis   +9 more
core   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

The association between body mass index and abdominal obesity with hypertension among South Asian population: findings from nationally representative surveys

Clinical Hypertension
Objective This study aimed to determine the association between body mass index (BMI) and abdominal obesity with hypertension among the South Asian adults (18–69 years).
Rajat Das Gupta, Ateeb Ahmad Parray, Rohan Jay Kothadia, Orindom Shing Pulock, Susmita Dey Pinky, Shams Shabab Haider, Maxwell Akonde, Mohammad Rifat Haider   +7 more
doaj   +1 more source

Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

Redox Biology, 2017
Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications.
Riikka Jokinen, Sini Pirnes-Karhu, Kirsi H. Pietiläinen, Eija Pirinen   +3 more
doaj   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Abdominal obesity: causal factor or simply a symptom of obesity-related health risk

, 2014
Sechang Oh,1 Kiyoji Tanaka,2 Jin-won Noh,3 Rina So,2,4 Takehiko Tsujimoto,2 Hiroyuki Sasai,1,4 Mijung Kim,5 Junichi Shoda11Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Faculty of Health and Sports Science, University of Tsukuba ...
Noh JW, Sasai H, Oh S, So R, Shoda J, Tsujimoto T, Tanaka K, Kim M   +7 more
core  

Prevalence of Overweight, Obesity, and Abdominal Obesity in Polish Adults: Sociodemographic Analysis from the 2016–2020 National Health Program

Introduction: Excessive body weight, particularly the abdominal distribution of adipose tissue, has remained an important public health concern for years.
Alicja Kucharska, Filip Raciborski, Iwona Traczyk, Mariusz Wyleżoł, Bolesław Samoliński, Beata I. Sińska, Mariusz Panczyk, Dorota Szostak-Węgierek, Piotr Samel-Kowalik, Anna Kłak   +9 more
core   +1 more source

Criteria for EASO-collaborating centres for obesity management

, 2011
Obesity is recognised as a global epidemic and the most prevalent metabolic disease world-wide. Specialised obesity services, however, are not widely available in Europe, and obesity care can vary enormously across European regions.
Hermann Toplak, Tsigos, C., Volkan Yumuk, Yves Schutz, Yumuk, V., Schutz, Yves, Roman, Gabriela, Tsigos, Constantine, Dragan Micic, Maximo Maislos, Basdevant, A., Yumuk, Volkan, Nick Finer, Constantine Tsigos, Mathus-Vliegen, E., Schutz, Y., Barbara Zahorska-Markiewicz, Basdevant, Arnaud, Finer, N., Yumuk, Volkan Demirhan, Hainer, V., Finer, Nick, Roman, G., Arnaud Basdevant, Maislos, M., Micic, Dragan, Toplak, Hermann, Micic, D., Toplak, H., Gabriela Roman, Zahorska-Markiewicz, B., Mathus-Vliegen, Elisabeth, Zahorska-Markiewicz, Barbara, Elisabeth Mathus-Vliegen, Vojtech Hainer, Maislos, Maximo, Hainer, Vojtech   +36 more
core   +1 more source