Results 121 to 130 of about 803,848 (312)

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

Splenic cyst deroofing complicated with B lymphoma

World Journal of Surgical Oncology
Background Splenic cysts are uncommon and very rarely malignant therefore their treatment isn’t standardized. In case of symptomatic cysts different surgical approaches have been suggested.
Iago Justo, Carlos Jiménez-Romero, Antonio Suárez, Pablo Vazquez, Enrique Revilla, Carmelo Loinaz, Mercedes Bernaldo de Quirós   +6 more
doaj   +1 more source

Laparoscopic surgery for hernias of the anterior abdominal wall

, 2021
А.А. Теувов, A.M. Baziev, Madina Hagismelovna Tlakadugova, E.M. Pshukova, Azamat Ibrahimovich Sardiyanov   +4 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

The implementation of a robotic surgical platform for the treatment of patients with malignant or pre-malignant pancreatic tumors at the University Medical Center Ljubljana

Radiology and Oncology
Robotic platforms are increasingly employed in the field of minimally invasive pancreatic surgery. It is essential to develop an innovative method that ensures both safety and efficacy, producing outcomes comparable to those of established treatment ...
Petric Miha, Polanco Patricio Marcelo, Grosek Jan, Tomazic Ales, Trotovsek Blaz, Plesnik Bostjan   +5 more
doaj   +1 more source

Operative complications and results of the "SPARC" procedure for stress urinary incontinence [Operativne komplikacije i ishod metode SPARC u liječenju statičke inkontinencije mokraće] [PDF]

, 2009
The aim of this study was to determine the efficacy and operative complications of the suprapubic arc (SPARC) procedure in stress incontinent women with and without previous anti-incontinence surgery.
Babić, Ivan, Gojević, Ante, Gregov, Marija, Kalafatić, Držislav, Lovrić Gršić, Helena, Orešković, Slavko   +5 more
core  

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

2022-RA-901-ESGO Open abdominal vacuum pack technique for the management of severe abdominal complications after cytoreductive surgery in ovarian cancer [PDF]

, 2022
Anne-Sophie Navarro, Carlos Martínez-Gómez, Martina Aida Ángeles, Régis Fuzier, Jean Ruiz, Muriel Picard, Alejandra Martínez, Gwénaël Ferron   +7 more
openalex   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

A Decade-Long Case Series Report on the Surgical Management of Complicated Umbilical Hernia in Patients with Decompensated Liver Cirrhosis Utilizing Incisional Negative Pressure Therapy

Medicina
Background and Objectives. Umbilical hernia is particularly common among patients with liver cirrhosis, affecting about 20% of this group, compared to 3–8.5% in healthy individuals.
Miha Petrič, Danaja Plevel, Uroš Tršan, Blaž Trotovšek   +3 more
doaj   +1 more source