Results 1 to 10 of about 94,309 (299)

Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats

Frontiers in Pharmacology
Co-use of opioids (e.g., fentanyl) and stimulants (e.g., methamphetamine; METH) contributed to >30% of the almost 106,000 fatal overdoses in the United States in 2023.
Jacqueline M. Vazquez, Robert W. Seaman, Drew Caldron, Gregory T. Collins, Gregory T. Collins   +4 more
doaj   +1 more source

Evaluating fentanyl test strips as a harm reduction strategy in rural and urban counties: study protocol for a randomized controlled trial

Trials
Background Opioid-related fatalities are a leading cause of death in Ohio and nationally, with an increasing number of overdoses attributable to fentanyl. Rapid fentanyl test strips can identify fentanyl and some fentanyl analogs in urine samples and are
Ashley Short Mejia, Gary A. Smith, Soledad A. Fernandez, Bridget Freisthler, Christine Grella, Nichole L. Michaels   +5 more
doaj   +1 more source

Determination of Common Metabolites for Methoxylated Fentanyl Analogs

Forensic Sciences
Background/Objectives: The opioid crisis is an ongoing problem in the United States, and fentanyl analogs play a major role in the issue, as novel fentanyl analogs are constantly being developed.
Jillian Morgan, Candice Bridge
doaj   +1 more source

Association between gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery

Molecular Pain, 2016
Background Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene.
Wataru Muraoka DDS, Daisuke Nishizawa PhD, Kenichi Fukuda DDS, PhD, Shinya Kasai PhD, Junko Hasegawa BAgr, Koichi Wajima DDS, PhD, Taneaki Nakagawa DDS, PhD, Kazutaka Ikeda PhD   +7 more
doaj   +1 more source

Intraoperative Isoflurane End-Tidal Concentration during Infusion of Fentanyl, Tramadol, or Fentanyl–Tramadol Combination in Cats

Veterinary Sciences
The aim of this study was to evaluate the end-tidal concentration of isoflurane required, clinical parameters, intraoperative antinociceptive effect, and postoperative analgesia in cats undergoing ovariohysterectomy, receiving fentanyl, tramadol, or ...
Claudia Interlandi, Fabio Bruno, Marco Tabbì, Francesco Macrì, Simona Di Pietro, Elisabetta Giudice, Patrizia Licata, Daniele Macrì, Viola Zappone, Giovanna Lucrezia Costa   +9 more
doaj   +1 more source

Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice

Addiction Neuroscience
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply.
Anthony M. Downs, Gracianne Kmiec, Zoé A. McElligott   +2 more
doaj   +1 more source

Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone

JCI Insight
The high frequency of opioid overdose deaths often involves co-use of alcohol, which is reported in approximately 30% of fentanyl fatalities. Both substances depress respiratory function, and their combined effects can be lethal.
Emma V. Frye, Lyndsay E. Hastings, Aniah N. Matthews, Adriana Gregory-Flores, Janaina C.M. Vendruscolo, Lindsay A. Kryszak, Shelley N. Jackson, Aidan J. Hampson, Nora D. Volkow, Leandro F. Vendruscolo, Renata C.N. Marchette, George F. Koob   +11 more
doaj   +1 more source

Intraoperative fentanyl in endoscopic procedures and their impact on PACU time and costs

Perioperative Medicine
Background Extended stays in the postanesthesia care unit (PACU) pose challenges in high-volume endoscopies. This study investigates the impact of intraoperative fentanyl use on PACU duration, postoperative pain, and financial implications in outpatient ...
Miho Akabane, Kelsey Kukuruza, Timothy Angelotti, Subhas Banerjee, Kazuo Ando   +4 more
doaj   +1 more source

Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone

Toxics
Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate transporter 1 (GLT-1) has been identified as a therapeutic target in several preclinical models of ...
Mohammed S. Alasmari, Fawaz Alasmari, Shakir D. Alsharari, Abdullah F. Alasmari, Nemat Ali, Syed Rizwan Ahamad, Abdullah M. Alghamdi, Aban A. Kadi, Alaa M. Hammad, Yousif S. Mohamed Ali, Wayne E. Childers, Magid Abou-Gharbia, Youssef Sari   +12 more
doaj   +1 more source

Dexmedetomidine Or Fentanyl as An Adjuvant to Single Low-Dose Bupivacaine Intrathecal Anesthesia for Management of Normal Labor Pain, A Randomized Control Study [PDF]

International Journal of Medical Arts
Background: To improve the quality of the analgesia, adjuvants were added to intrathecal bupivacaine. The purpose of this work was to assess the efficacy of intrathecal dexmedetomidine [DEX] and fentanyl in reducing pain during delivery, patient ...
Khaled Shrief, Essam Abd El Wahab, Ismail Ahmed, Hany Ramadan   +3 more
doaj   +1 more source