Results 1 to 10 of about 184,026 (339)

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor

Cell, 2022
Morphine and fentanyl are among the most used opioid drugs that confer analgesia and unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid receptor (μOR).
Youwen Zhuang, Shimeng Guo, Qingtong Zhou   +2 more
exaly   +2 more sources

Fentanyl and its derivatives: Pain-killers or man-killers?

Heliyon
Fentanyl is a synthetic μ-opioid receptor agonist approved to treat severe to moderate pain with faster onset of action and about 100 times more potent than morphine.
Jiri Patocka, Wenda Wu, Patrik Oleksak, Romana Jelinkova, Eugenie Nepovimova, Lenka Spicanova, Pavlina Springerova, Suliman Alomar, Miao Long, Kamil Kuca   +9 more
doaj   +2 more sources

Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment

Neuroscience and Biobehavioral Reviews, 2019
Opioid overdoses, many of which are attributed to use of illicit fentanyl, are currently one of the leading causes of death in the U.S. Although fentanyl has been used safely for decades in clinical settings, the widespread use of illicit fentanyl is a ...
Catherine M Cahill
exaly   +2 more sources

Charting the Fourth Wave: Geographic, Temporal, Race/Ethnicity, and Demographic Trends in Polysubstance Fentanyl Overdose Deaths in the United States, 2010-2021

medRxiv, 2022
Aims: To characterize polysubstance death in the United States during the transition to the fourth wave of the overdose crisis. To characterize co-involved substances in fatal overdose involving synthetic opioids (mainly illicitly manufactured fentanyl ...
Joseph R. Friedman, Chelsea L. Shover
semanticscholar   +1 more source

Prevalence of fentanyl in methamphetamine and cocaine samples collected by community-based drug checking services.

Drug and Alcohol Dependence, 2023
BACKGROUND Overdose deaths involving stimulants and opioids simultaneously have raised the specter of widespread contamination of the stimulant supply with fentanyl.
Karla D. Wagner, Philip Fiuty, Kimberly Page, E.C. Tracy, Maryalice Nocerd, C. Miller, Lina Tarhuni, N. Dasgupta   +7 more
semanticscholar   +1 more source

Fentanyl Absorption, Distribution, Metabolism, and Excretion: Narrative Review and Clinical Significance Related to Illicitly Manufactured Fentanyl

Journal of addiction medicine, 2023
Objectives This narrative review summarizes literature on pharmaceutical fentanyl's absorption, distribution, metabolism, and excretion patterns to inform research on illicitly manufactured fentanyl (IMF).
PharmD H. Elizabeth Bird, P. M. Andrew S. Huhn, P. M. Kelly E. Dunn   +2 more
semanticscholar   +1 more source

Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of EGFR

BMC Anesthesiology, 2022
Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain management. Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian cancer ...
Kai Xiao, Qinghong Zheng, Lei Bao
doaj   +1 more source

Effects of neonatal fentanyl on late adolescent opioid-mediated behavior

Frontiers in Neuroscience, 2023
IntroductionBecause of the steady increase in the use of synthetic opioids in women of childbearing age, a large number of children are at risk of exposure to these drugs prenatally or postnatally through breast milk.
Cynthia A. Crawford, Jordan A. Taylor, Ginny I. Park, Jasmine W. Rios, Joseph Bunch, Constance J. Greenwood, David Y. Lopez Sanchez, Diego J. Gonzales   +7 more
doaj   +1 more source

Assessment of two brands of fentanyl test strips with 251 synthetic opioids reveals “blind spots” in detection capabilities

Harm Reduction Journal, 2023
Background Fentanyl test strips (FTS) are a commonly deployed tool in drug checking, used to test for the presence of fentanyl in street drug samples prior to consumption.
Kathleen L. Hayes, Marya Lieberman
doaj   +1 more source

Trends in seizures of powders and pills containing illicit fentanyl in the United States, 2018 through 2021.

Drug and Alcohol Dependence, 2022
BACKGROUND Prevalence of fentanyl-laced counterfeit prescription pills has been increasing in the US, possibly placing a wider population at risk for unintentional exposure.
J. Palamar, D. Ciccarone, Caroline Rutherford, K. Keyes, Thomas H. Carr, L. Cottler   +5 more
semanticscholar   +1 more source