Results 11 to 20 of about 94,309 (299)

Abuse potential of fentanyl and fentanyl analogues [PDF]

open access: yesBioImpacts
Introduction: In this perspective review, we evaluated the clinical management of fatal fentanyl overdose in several routes of administration, concentrating on both legally prescribed and illegally produced formulations. Methods: A literature search was conducted on Web of Science, PubMed, and Google Scholar databases, using the following keywords ...
Anusha Thumma   +5 more
openaire   +5 more sources

Fentanyl, carfentanil and other fentanyl analogues in Canada’s illicit opioid supply: A cross-sectional study

open access: yesDrug and Alcohol Dependence Reports
Background: Despite the increase in fentanyl-involved overdose deaths in Canada, there have been no national-level studies evaluating the proportion of illicit opioids containing fentanyl or fentanyl analogues in Canada.
Robert A. Kleinman
exaly   +3 more sources

Fentanyl Induces Behavioral Sensitization and Decreases Class IIa HDAC Expression-Activity in Brain as Measured by [18F]TFAHA PET Imaging in Female and Male Rats [PDF]

open access: yesBrain Sciences
Background: Although fentanyl significantly contributes to opioid-related morbidity and mortality, little is known about the epigenetic changes that may influence long-term neuronal adaptations.
Cameron J. Davidson   +10 more
doaj   +2 more sources

Role of intranasal fentanyl in breakthrough pain management in cancer patients [PDF]

open access: yesCancer Management and Research, 2010
Wojciech LeppertDepartment of Palliative Medicine, Poznan University of Medical Sciences, Poznan, PolandAbstract: Fentanyl is a strong opioid analgesic, which is commonly used in the form of a transdermal patch for the treatment of chronic cancer pain ...
Wojciech Leppert
doaj   +2 more sources

Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of EGFR

open access: yesBMC Anesthesiology, 2022
Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain management. Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian cancer ...
Kai Xiao, Qinghong Zheng, Lei Bao
doaj   +1 more source

Identifying Fentanyl with Mass Spectral Libraries [PDF]

open access: yes, 2021
Synthesis, distribution and abuse of fentanyl, a synthetic opioid, has led to a critical worldwide epidemic. Mass spectral library searching for opioids remains unresolved despite being central to law-enforcement involving identification ...
Anthony J., Kearsley, Arun, Moorthy
core   +1 more source

Assessment of two brands of fentanyl test strips with 251 synthetic opioids reveals “blind spots” in detection capabilities

open access: yesHarm Reduction Journal, 2023
Background Fentanyl test strips (FTS) are a commonly deployed tool in drug checking, used to test for the presence of fentanyl in street drug samples prior to consumption.
Kathleen L. Hayes, Marya Lieberman
doaj   +1 more source

Mass Spectral Character of Fentanyl Analogues [PDF]

open access: yesFayixue Zazhi, 2019
Objective To provide the reference for the identification of unknown fentanyl analogues by studying the characteristic ions and main fragmentation pathways of fentanyl analogues in the modes of collision induced dissociation (CID) and electron ionization
YAN Jin, HUA Zhen-dong, JIA Wei, et al.
doaj   +1 more source

Effects of neonatal fentanyl on late adolescent opioid-mediated behavior

open access: yesFrontiers in Neuroscience, 2023
IntroductionBecause of the steady increase in the use of synthetic opioids in women of childbearing age, a large number of children are at risk of exposure to these drugs prenatally or postnatally through breast milk.
Cynthia A. Crawford   +7 more
doaj   +1 more source

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

open access: yesComputational and Structural Biotechnology Journal, 2022
Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the recreational drug market and are the main culprits for the opioid crisis, which has been exacerbated by the COVID-19 ...
Bing Xie, Alexander Goldberg, Lei Shi
doaj   +1 more source

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