Results 41 to 50 of about 97,186 (299)

3D Printed Photon Shield Assembly for Low‐Noise Visual Stimulation During Two‐Photon Imaging in Mice

Advanced Materials Technologies, EarlyView.
We present the Photon Shield, an open‐hardware system for low‐noise two‐photon calcium imaging during visual stimulation in mice. Combining a 3D‐printed headplate and rail‐mounted shield substantially reduces stray‐light contamination, as quantitatively verified. Functional validation confirms reliable cortical responses. Open design files enable broad
Gergely Katona, Andrea Slézia, András Dávid, Ábel Petik, Dániel Hillier, István Ulbert, Attila Kaszás   +6 more
wiley   +1 more source

Higher doses of naloxone are needed in the synthetic opioid era

Substance Abuse Treatment, Prevention, and Policy, 2019
There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses.
Ronald B. Moss, Dennis J. Carlo
doaj   +1 more source

Investigation of monoclonal antibody CSX-1004 for fentanyl overdose

Nature Communications, 2023
The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid fentanyl leading to >70,000 overdose deaths annually; thus, new therapies for fentanyl overdose are urgently needed. Here, we present the first clinic-ready,
Paul T. Bremer, Emily L. Burke, Andrew C. Barrett, Rajeev I. Desai   +3 more
doaj   +1 more source

Comparative study of haemodynamic effects of intravenous ketamine-fentanyl and propofol-fentanyl for laryngeal mask airway insertions in children undergoing herniotomy under general anaesthesia in a nigerian tertiary hospital

Nigerian Postgraduate Medical Journal, 2022
Background: Insertion of laryngeal mask airway (LMA) with propofol in children may cause hypotension, laryngospasm and apnoea. Ketamine and fentanyl have been combined separately with propofol to prevent depression of cardiovascular system during LMA ...
Ajibade Okeyemi, Aliyu Zakari Suleiman, Olubukola Olanrewaju Oyedepo, Benjami Olusomi Bolaji, Babajide Majeed Adegboye, Olufemi Adebayo Ige   +5 more
doaj   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Spectral Barcoding for the Detection of Fentanyl and Fentanyl Analogs Using Raman Spectroscopy

Applied Spectroscopy Practica
Fentanyl and fentanyl analogs are the drugs most often implicated in opioid overdose fatalities. Law and drug enforcement agencies are actively working to remove fentanyl-containing drugs from circulation; however, detection in the field can be ...
Phillip G. Wilcox, Deborah M. Stiffler, Andrew J. Walz, James M. Myslinski, Jason A. Guicheteau   +4 more
doaj   +1 more source

Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]

, 2007
The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Colorimetric detection of fentanyl using a supramolecular displacement assay [PDF]

Fentanyl is a potent synthetic opioid with an alarmingly low lethal dosage of 2 mg. The equipment necessary to detect fentanyl in field settings (e.g., handheld spectrometers) is restricted to highly trained, well-funded, and specialized personnel ...
Patrick, Reust, Piercen, Oliver, Charles R., Mace, Amanda, Code, Andrea C., Mora, Madeline , Vara   +5 more
core   +2 more sources

Weather Attention in Online Discourse and Price Uncertainty in Agricultural Futures Markets

Agribusiness, EarlyView.
ABSTRACT Weather is a central determinant of production risk in agricultural markets, but markets respond not only to weather conditions themselves, but also to how those conditions are noticed, framed, and interpreted in public discourse. In this setting, real‐time online weather discussions may shape price uncertainty by influencing how market ...
Mario A. Ortez, Olga Isengildina Massa, Michael Liam Smith, Nicole Olynk Widmar   +3 more
wiley   +1 more source

Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle

Addiction Neuroscience
The orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrease fentanyl ...
David De Sa Nogueira, Chuhyon Corwin, Yogesh Rakholia, Varnitha Punnuru, Meghana Nampally, Amy S. Kohtz, Gary Aston-Jones   +6 more
doaj   +1 more source