Spectral Barcoding for the Detection of Fentanyl and Fentanyl Analogs Using Raman Spectroscopy
Applied Spectroscopy PracticaFentanyl and fentanyl analogs are the drugs most often implicated in opioid overdose fatalities. Law and drug enforcement agencies are actively working to remove fentanyl-containing drugs from circulation; however, detection in the field can be ...
Phillip G. Wilcox +4 more
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Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
Frontiers in Pharmacology, 2021 Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and suppression of breathing in humans and animals. To date, there is limited evidence as to whether changes in oxidant stress are important factors in any of the actions ...
Santhosh Baby +9 more
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Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle
Addiction NeuroscienceThe orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrease fentanyl ...
David De Sa Nogueira +6 more
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High and Hyper: Fentanyl Induces Psychomotor Side-Effects in Healthy Pigs
Animals, 2023 Analgesic effects of fentanyl have been investigated using behavior. The behavioral effects of fentanyl and possible serotonergic influence are largely unknown.
Nora Digranes +2 more
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Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]
, 2007 The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R. +2 more
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On the challenge of unambiguous identification of fentanyl analogs: exploring measurement diversity using standard reference mass spectral libraries [PDF]
, 2023 Fentanyl analogs are a class of designer drugs that are particularly challenging to unambiguously identify due to the mass spectral and retention time similarities of unique compounds.
William, Wallace +5 more
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A humanized monoclonal antibody attenuates carfentanil self-administration in nonhuman primates
Drug and Alcohol Dependence ReportsApproximately 70 % of fatal drug overdoses in the United States are attributed to fentanyl and fentanyl analogs. Current medications for reversing overdose and treating opioid use disorder might not be as effective against fentanyl and fentanyl analogs ...
Lindsey K. Galbo-Thomma +5 more
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Colorimetric detection of fentanyl using a supramolecular displacement assay [PDF]
Fentanyl is a potent synthetic opioid with an alarmingly low lethal dosage of 2 mg. The equipment necessary to detect fentanyl in field settings (e.g., handheld spectrometers) is restricted to highly trained, well-funded, and specialized personnel ...
Patrick, Reust +5 more
core +1 more source
Correlates of fentanyl preference among people who use drugs in Rhode Island
Harm Reduction JournalBackground Fentanyl is increasingly pervasive in the unregulated drug supply and is a driver of drug overdose deaths in the United States. The aims of this study were to characterize and identify correlates of fentanyl preference among people who use ...
Siena C. Napoleon +8 more
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Indian Journal of Anaesthesia, 2019 Background and Aims: Fentanyl can facilitate controlled intraoperative hypotension by its sympatholytic effect in patients undergoing functional endoscopic sinus surgery (FESS).
Prabhat Choudhary +5 more
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