Results 51 to 60 of about 184,026 (339)

“It wasn’t here, and now it is. It’s everywhere": fentanyl’s rising presence in Oregon’s drug supply

Harm Reduction Journal, 2022
Background Illicit fentanyl has contributed to a drastic increase in overdose drug deaths. While fentanyl has subsumed the drug supply in the Northeastern and Midwestern USA, it has more recently reached the Western USA.
Sarah S. Shin, Kate LaForge, Erin Stack, Justine Pope, Gillian Leichtling, Jessica E. Larsen, Judith M. Leahy, Andrew Seaman, Daniel Hoover, Laura Chisholm, Christopher Blazes, Robin Baker, Mikaela Byers, Katie Branson, P. Todd Korthuis   +14 more
doaj   +1 more source

Investigation of monoclonal antibody CSX-1004 for fentanyl overdose

Nature Communications, 2023
The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid fentanyl leading to >70,000 overdose deaths annually; thus, new therapies for fentanyl overdose are urgently needed. Here, we present the first clinic-ready,
Paul T. Bremer, Emily L. Burke, Andrew C. Barrett, Rajeev I. Desai   +3 more
doaj   +1 more source

Comparative study of haemodynamic effects of intravenous ketamine-fentanyl and propofol-fentanyl for laryngeal mask airway insertions in children undergoing herniotomy under general anaesthesia in a nigerian tertiary hospital

Nigerian Postgraduate Medical Journal, 2022
Background: Insertion of laryngeal mask airway (LMA) with propofol in children may cause hypotension, laryngospasm and apnoea. Ketamine and fentanyl have been combined separately with propofol to prevent depression of cardiovascular system during LMA ...
Ajibade Okeyemi, Aliyu Zakari Suleiman, Olubukola Olanrewaju Oyedepo, Benjami Olusomi Bolaji, Babajide Majeed Adegboye, Olufemi Adebayo Ige   +5 more
doaj   +1 more source

Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice

Scientific Reports, 2023
The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo, Sarah Brunty, Jessica Huffman, Alexis Kastigar, Price E. Dickson   +4 more
doaj   +1 more source

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

Translational Psychiatry, 2019
Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an increasing public health threat in the United States and elsewhere.
Ying Han, Wei Yan, Yongbo Zheng, M. Z. Khan, K. Yuan, Lin Lu   +5 more
semanticscholar   +1 more source

Criminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado’s criminal legal penalties

BMC Global and Public Health
Background In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk.
Katherine LeMasters, Samantha K. Nall, Cole Jurecka, Betsy Craft, Paul J. Christine, Ryan Goodman, Jessie Henderson, Robert Haywood-James, Angela Williams, Grace Wittner, Joshua A. Barocas   +10 more
doaj   +1 more source

Efficacy of Intrathecal Fentanyl for Cesarean Delivery: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis.

Anesthesia and Analgesia, 2020
BACKGROUND Fentanyl and morphine are the 2 most commonly added opioids to bupivacaine for spinal anesthesia during cesarean delivery. Numerous clinical trials have assessed efficacy and safety of different doses of fentanyl added to intrathecal ...
V. Uppal, S. Retter, M. Casey, S. Sancheti, K. Matheson, D. McKeen   +5 more
semanticscholar   +1 more source

Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry [PDF]

, 2017
The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the
Moore, Amanda Marie
core  

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Pharmacokinetic Profile of Fentanyl in the Koala (Phascolarctos cinereus) after Intravenous Administration, and Absorption via a Transdermal Patch

Animals, 2021
Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA).
Fumie Tokonami, Benjamin Kimble, Merran Govendir   +2 more
doaj   +1 more source