Results 111 to 120 of about 82,878 (275)

Revisiting Ontology to Reshape Transgenerational Justice

Global Policy, EarlyView.
ABSTRACT This article develops a philosophical framework for understanding transgenerationality as a foundational concept for intergenerational justice. Drawing on social ontology and the philosophy of action, it introduces the notion of transgenerational civitas—a temporally extended community composed of past, present and future generations.
Tiziana Andina
wiley   +1 more source

Low‐Carbon Transition and Active Management: Evidence From Emerging Market Funds

Business Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT Previous literature finds mixed evidence on the performance of emerging mutual funds and how investors are becoming more aware of investing in companies involved in low‐carbon emission activities. Given the opportunities that emerging markets and sustainable investing offer to active management, this study aims to fill a gap in the literature ...
Juan Carlos Matallín‐Sáez, Amparo Soler‐Domínguez, Diego Víctor de Mingo‐López   +2 more
wiley   +1 more source

Navigating through uncertainty—Experience from the UK national VEXAS MDT

British Journal of Haematology, EarlyView.
Summary The objective of this study was to describe the establishment, structure and influence of the United Kingdom national multidisciplinary team (MDT) for vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic (VEXAS) syndrome and to assess its clinical outputs and perceived value among participating clinicians.
Daniel Pietsch, Austin Kulasekararaj, Sinisa Savic, on behalf of VEXNET‐UK MDT, Adam Al‐Hakim, Tanya Basu, Catherine Cargo, Onima Chowdhry, James Galloway, Eiphyu Htut, Stephen Jolles, Arvind Kaul, Helen Lachmann, Calman A. MacLennan, Anoop Mistry, Elspeth Payne, James Poulter, Farzana Rahman, Manoj Raghavan, Rachel Tattersall, Roochi Trikha, Villyn Yong, Taryn Youngstein, Anna Babb, Celia Beynon, Sarah Bingham, Nuno Borges, Jenny Bosworth, Carlos Campani, Marian Chan, Shikha Chattree, Niall Conlon, Robert Corser, Elena Ganendra, Paraskevi Gkreka, William Gordon, Elisabeth Grey‐Davies, Joanna Haughton, Simona Huica, Pawel Kaczmarek, Alison Laing, Areti Makrygeorgou, Susanna Mathew, Jill Mccormick, Muhammad Mohsin, Vidhya Murthy, Sateesh Nagumantry, Ognjenka Savanovic‐Abel, Shaun Smale, Alex Sternberg, Rosemary Waller, Sarah Westbury   +51 more
wiley   +1 more source

Dust Universes in Higher Dimensions with Gauss–Bonnet Corrections

Universe
We study dust models in higher-dimensional general relativity and the Einstein–Gauss–Bonnet theory in a maximally symmetric spacetime. We show that the dynamics of the model is governed by an Abel differential equation of the second kind.
Sumeekha Singh, Byron P. Brassel, Sunil D. Maharaj   +2 more
doaj   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Single‐Cell Analysis Identified a Recurrent Malignant‐Associated Transcriptional State in Colorectal Cancer

Cancer Science, EarlyView.
Colorectal cancer (CRC) shows high molecular heterogeneity, yet single‐cell data from Japanese patients are limited. We performed scRNA‐seq on tumors and adjacent normal tissues from four Japanese CRC patients and identified a shared malignant cell cluster with high KCNQ1OT1 expression and reduced RASSF6 levels.
Sadahiro Iwabuchi, Kentaro Sawada, Motohiro Kojima, Miho Ozawa, Hiroya Taniguchi, Hideaki Bando, Kazumi Abe, Yuta Kuze, Kiyomi Imamura, Yukie Kashima, Yoshihiko Hirohashi, Atsushi Tajima, Toshihiko Torigoe, Yutaka Suzuki, Takayuki Yoshino, Shinichi Hashimoto   +15 more
wiley   +1 more source

Brain Drain and Productivity Growth: Evidence From South Africa, 1947–2019

Economics of Transition and Institutional Change, EarlyView.
ABSTRACT This paper provides empirical evidence of how high‐level human capital outflow could affect TFP‐based economic development and vice versa. The concern of potential endogeneity between brain drain and economic development is addressed directly.
Johannes Fedderke, Xiaodi Dong
wiley   +1 more source

The status of thegn in late Anglo‐Saxon England

Early Medieval Europe, EarlyView.
This article considers how the term ‘thegn’ was used in tenth‐ and eleventh‐century England. Although commonly thought to indicate members of a face‐to‐face service aristocracy with specific attributes, it has resisted close definition. Examination of references to anonymous thegns in administrative and legal texts suggests that the people meant were ...
Richard Purkiss
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Constant invariant solutions of the Poincare center-focus problem

Electronic Journal of Differential Equations, 2010
We consider the classical Poincare problem $$ frac{dx}{dt}=-y-p(x,y),quad frac{dy}{dt}=x+q(x,y) $$ where $p,q$ are homogeneous polynomials of degree $n geq 2$.
Gary R. Nicklason
doaj