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Single‐Cell Analysis Identified a Recurrent Malignant‐Associated Transcriptional State in Colorectal Cancer

Cancer Science, EarlyView.
Colorectal cancer (CRC) shows high molecular heterogeneity, yet single‐cell data from Japanese patients are limited. We performed scRNA‐seq on tumors and adjacent normal tissues from four Japanese CRC patients and identified a shared malignant cell cluster with high KCNQ1OT1 expression and reduced RASSF6 levels.
Sadahiro Iwabuchi +15 more
wiley +1 more source

Brain Drain and Productivity Growth: Evidence From South Africa, 1947–2019

Economics of Transition and Institutional Change, EarlyView.
ABSTRACT This paper provides empirical evidence of how high‐level human capital outflow could affect TFP‐based economic development and vice versa. The concern of potential endogeneity between brain drain and economic development is addressed directly.
Johannes Fedderke, Xiaodi Dong
wiley +1 more source

Numerical Solutions of Linear Abel Integral Equations Via Boubaker Polynomials Method

مجلة بغداد للعلوم
In this article, a numerical method based on Boubaker polynomials (BPs) was presented to solve the Linear Abel integral (LAI) Eqs of first and second types. The matrices were used to form the (LAI) Eq into a system of linear Eqs.
Jalil Talab Abdullah +2 more
doaj +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source

Financial Statement Information and Equity Value: The Role of Real Options Characteristics

Financial Management, EarlyView.
ABSTRACT This paper examines whether firm‐specific real options characteristics are equity value‐relevant beyond valuation estimates anchored in financial statements. Using extensive historical data for the United Kingdom, we assess and compare the forecast accuracy and explanatory power for stock prices of equity valuation models based on residual ...
Mingyu (Chandler) Chen, Colin Clubb, Tarik Driouchi +2 more
wiley +1 more source

A (2 + 1)-Dimensional Integrable Breaking Soliton Equation and Its Algebro-Geometric Solutions

Mathematics
A new (2 + 1)-dimensional breaking soliton equation with the help of the nonisospectral Lax pair is presented. It is shown that the compatible solutions of the first two nontrivial equations in the (1 + 1)-dimensional Kaup–Newell soliton hierarchy ...
Xiaohong Chen, Tiecheng Xia, Liancheng Zhu +2 more
doaj +1 more source

Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques

Hepatology Research, EarlyView.
The supervised clustering of metabolic dysfunction‐associated steatotic liver disease (MASLD) using a SHapley Additive exPlanations (SHAP)‐converted matrix reveals distinct subpopulations that improved risk stratification for new onset of chronic kidney disease (CKD).
Itaru Hosaka +14 more
wiley +1 more source

Rational solutions and limit cycles of polynomial and trigonometric Abel equations

Electronic Journal of Qualitative Theory of Differential Equations
e study the Abel differential equation $x'=A(t)x^3+B(t)x^2+C(t)x$. Specifically, we find bounds on the number of its rational solutions when $A(t), B(t)$ and $C(t)$ are polynomials with real or complex coefficients; and on the number of rational limit ...
Luis Ángel Calderón
doaj +1 more source

Calibration and discrimination ability of the Dat'AIDS score in people living with HIV aged 70 years and older from the Dat'AIDS cohort

HIV Medicine, EarlyView.
Abstract Objective The Dat'AIDS score was developed to predict 5‐year mortality risk in people living with HIV aged 60 and older. However, its validity in people living with HIV aged 70 years and older needed confirmation. Methods This was a multicentre prospective cohort study in the Dat'AIDS French cohort.
Abeo Mousse +337 more
wiley +1 more source

Missed opportunities to prevent HIV acquisition with pre‐exposure prophylaxis: A mixed methods study of people with recently acquired HIV in the United Kingdom

HIV Medicine, EarlyView.
Abstract Objectives To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom. Methods Data were derived from CASCADE, an international, longitudinal, mixed‐methods study of adults (≥16 years) with recently acquired HIV (≤12 months).
Argyro Karakosta +145 more
wiley +1 more source

mathematics
abel equation
abel differential equation

limit cycle
periodic orbits
periodic solution

error analysis
abel integral equation
analysis