Results 131 to 140 of about 100,646 (310)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Aberrations in Theories of Optical Aberrations
IOSR Journal of Applied Physics, 2017 P. Rama Krishna, D. Karuna Sagar
openaire +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Farbenmischung in Folge der chromatischen Aberration des Auges
, 1903 FARBENMISCHUNG IN FOLGE DER CHROMATISCHEN ABERRATION DES AUGES Farbenmischung in Folge der chromatischen Aberration des Auges (98) (-
Veress, Elemér
core
On the construction of restricted minimum aberration designs
, 2014 Deriving a formula, we show that an optimal moment design has the property that each treatment combination appears as equally often as possible. Modifying the definition of minimum aberration to restricted minimum aberration, we show that the word length
SUEN, CY +5 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Reconstructed wavefront aberration coefficients and residual errors.
, 2016 Reconstructed wavefront aberration coefficients and residual errors.
Zongyang Wang (2550940) +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2013 This thesis deals with the theoretical analysis of rays passing through lenses. Emphasis on optical defects, particularly focusing on spherical aberration lenses. It also includes the preparation of a workplace and the measurement of spherical aberration
Fojtík, Tomáš
core