Results 81 to 90 of about 243,905 (335)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Analysis of the Problems of the Research and Modernization of Emission Units of Analytical Devices of Vacuum Electronics

Applied Sciences
In various electron-optical and ion-beam devices and vacuum electronics installations, emission elements and units are used to extract and form beams of charged particles.
Alpamys T. Ibrayev, Aigerim B. Sagyndyk
doaj   +1 more source

Modelling of optical traps for aerosols

, 2010
Experimental observations suggest that there are differences between the behavior of particles optically trapped in air and trapped in a liquid phase.
Ashkin, Barker, Burnham, Burnham, Daniel R. Burnham, David McGloin, Di Leonardo, Dutra, Farsund, Hertlein, Hopkins, Joykutty, Keen, Knoner, Knox, Labiris, Lang, Li, Maia Neto, Mazolli, McCann, McGloin, McGloin, Metzger, Milne, Mitchem, Nieminen, Nieminen, Richards, Roosen, Stilgoe, Sun, Symes, Theofanidou, Török, Török, Viana, Zhao   +37 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis on Beam Quality of Solid-State Tube MOPA System With Zigzag Beam Path

IEEE Photonics Journal, 2019
All-solid-state tube lasers (ASSTLs) with zigzag beam path combine the attractive properties of rod, slab, and disk lasers. However, the analysis on the beam quality of tube lasers is rarely reported.
Boyu Tian, Zheqiang Zhong, Cong Huang, Xiaomin Zhang, Bin Zhang   +4 more
doaj   +1 more source

Coherent X-ray Diffractive Imaging; applications and limitations

, 2003
The inversion of a diffraction pattern offers aberration-free diffraction-limited 3D images without the resolution and depth-of-field limitations of lens-based tomographic systems, the only limitation being radiation damage.
A. Szoke, Beetz, Chapman, Elser, Fienup, H. He, H. N. Chapman, H. Padmore, He, Heel, Hegerl, Henke, J. C. H. Spence, M. R. Howells, McEwen, McGuire, Meyer-Ilse, Miao, Miao, Miao, Neutze, R. A. London, R. Rosen, S. Marchesini, S. P. Hau-Riege, Sayre, Solem, Solem, Spence, Szoke, Szöke, U. Weierstall, Weierstall, Zuo   +33 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source