Results 101 to 110 of about 55,264 (288)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Just-Noticeable Levels of Aberration Correction

open access: yesJournal of Optometry, 2008
Purpose: The objectives of this study were to determine whether the correction of higher-order aberrations (HOA) would be detectable by “normal” subjects and whether a full correction is necessary or better than a partial correction of the main HOA (i.e.,
Richard Legras, Hélène Rouger
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Snapshot 3D tracking of insulin granules in live cells

open access: yes, 2018
Rapid and accurate volumetric imaging remains a challenge, yet has the potential to enhance understanding of cell function. We developed and used a multifocal microscope (MFM) for 3D snapshot imaging to allow 3D tracking of insulin granules labeled with ...
Alan Selewa   +8 more
core   +1 more source

Systematic Review of Phase Aberration Correction Algorithms for Transcranial Focused Ultrasound

open access: yesiRADIOLOGY
Transcranial focused ultrasound (tFUS) is an emerging modality with strong potential for non‐invasively treating brain disorders. However, the inhomogeneity and complex structure of the skull induce substantial phase aberrations and pressure attenuation;
Mingyu Wang, Zhouyang Xu, Bingbing Cheng
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Recovering pyramid WS gain in non-common path aberration correction mode via deformable lens

open access: yes, 2017
It is by now well known that pyramid based wavefront sensors, once in closed loop, have the capability to improve more and more the gain as the reference natural star image size is getting smaller on the pyramid pin. Especially in extreme adaptive optics
Bergomi, M.   +7 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Active Control of Laser Wavefronts in Atom Interferometers

open access: yes, 2017
Wavefront aberrations are identified as a major limitation in quantum sensors. They are today the main contribution in the uncertainty budget of best cold atom interferometers based on two-photon laser beam splitters, and constitute an important limit ...
Langlois, Mehdi   +3 more
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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