Results 1 to 10 of about 173,192 (362)

N-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stability

mAbs, 2021
Antibody–drug conjugates (ADCs) are targeted therapeutic agents that treat cancers by selective delivery of highly potent cytotoxic drugs to tumor cells via cancer-specific antibodies. However, their clinical benefit is limited by off-target toxicity and
Min Ji Ko, Daehae Song, Juhee Kim, Jae Yong Kim, Jaehyun Eom, Byungje Sung, Yong-Gyu Son, Young Min Kim, Sang Hoon Lee, Weon-Kyoo You, Jinwon Jung   +10 more
doaj   +1 more source

Asymmetric anti-CLL-1×CD3 bispecific antibody, ABL602 2+1, with attenuated CD3 affinity endows potent antitumor activity but limited cytokine release

Journal for ImmunoTherapy of Cancer, 2023
Background Acute myeloid leukemia (AML) is a type of leukemia in adults with a high mortality rate and poor prognosis. Although targeted therapeutics, chemotherapy, and hematopoietic stem cell transplantation can improve the prognosis, the recurrence ...
Eunhee Lee, Yong-Gyu Son, Shinai Lee, Yangmi Lim, Jonghwa Won, Sumyeong Park, Jiseon Yoo, Youngil Koh, Dong-Yeop Shin   +8 more
doaj   +1 more source

From Capillary Electrophoresis to Deep Sequencing: An Improved HIV-1 Drug Resistance Assessment Solution Using In Vitro Diagnostic (IVD) Assays and Software

Viruses, 2023
Background: Drug-resistance mutations were mostly detected using capillary electrophoresis sequencing, which does not detect minor variants with a frequency below 20%.
Sofiane Mohamed, Ronan Boulmé, Chalom Sayada   +2 more
doaj   +1 more source

Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade

Journal for ImmunoTherapy of Cancer, 2021
Background Stimulation of 4-1BB with agonistic antibodies is a promising strategy for improving the therapeutic efficacy of immune checkpoint inhibitors (ICIs) or for overcoming resistance to ICIs.
Lei Fang, Wenqing Jiang, Zhengyi Wang, Su-Hyung Park, Eui-Cheol Shin, Minwoo Jeon, Jaeho Jung, Hyunjoo Kim, Hyung-Don Kim, Shin Hwang, Seongju Jeong, Eunyoung Park, Eunsil Sung, Jaehyoung Jeon, Youngkwang Kim, Ui-jung Jung, Yong-Gyu Son, Youngeun Hong, Hanbyul Lee, Shinai Lee, Yangmi Lim, Jonghwa Won   +21 more
doaj   +1 more source

Detection of derivative 9 deletion by BCR-ABL fluorescence in-situ hybridization signal pattern to evaluate treatment response in CML patients [PDF]

Archive of Oncology, 2009
Background: To evaluate prognostic effect of submicroscopic deletions involving breakage and fusion points of the derivative chromosome 9 and 22 in chronic myeloid leukemia in untreated patients and their follow up samples to correlate with disease ...
Bakshi Sonal R., Shah Pankaj M., Shukla Shilin N., Dalal Esha N., Iyer Ramesh R., Brahmbhatt Manisha M., Gajjar Sarju B., Trivedi Pina J., Patel Beena P.   +8 more
doaj   +1 more source

Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies

Vaccines, 2021
Following the clinical success of cancer immunotherapies such as immune checkpoint inhibitors blocking B7/CTLA-4 or PD-1/PD-L1 signaling and ongoing numerous combination therapies in the clinic,3 bispecific antibodies (BsAbs) are now emerging as a ...
Gihoon You, Jonghwa Won, Yangsoon Lee, Dain Moon, Yunji Park, Sang Hoon Lee, Seung-Woo Lee   +6 more
doaj   +1 more source

New records of lichen genera and species for Colombia

Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, 2022
Dirina paradoxa, Heterocyphelium triseptatum, Julella sublactea, Opegrapha aurantiaca, Peltula steppae, Sarcographina cyclospora and Schistophoron tenue are reported for the first time in Colombia.
Edier Alberto Soto, André Aptroot, Robert Lücking   +2 more
doaj   +1 more source

Autoinhibition of c-Abl [PDF]

Cell, 2002
Despite years of investigation, the molecular mechanism responsible for regulation of the c-Abl tyrosine kinase has remained elusive. We now report inhibition of the catalytic activity of purified c-Abl in vitro, demonstrating that regulation is an intrinsic property of the molecule.
Pluk, Helma, Dorey, Karel, Superti-Furga, Giulio   +2 more
openaire   +5 more sources

Pemanfaatan limbah lumpur aktif (LLA) sebagai adsorben untuk meminimalisir zat pencemar dalam air dan air limbah : Sebuah Ulasan

JLI: Jurnal Litbang Industri, 2020
Artikel review ini merangkum tentang pemanfaatan limbah lumpur aktif (LLA) sebagai  bahan prekursor untuk menghasilkan adsorben dan aplikasinya terhadap material pencemar lingkungan seperti pewarna dan logam berat.  Kinerja adsorben berbasis lumpur (ABL)
Salmariza Sy
doaj   +1 more source

Exploring Reggeon bound states in strongly-coupled N $$ \mathcal{N} $$ = 4 super Yang-Mills

Journal of High Energy Physics, 2022
The multi-Regge limit of scattering amplitudes in strongly-coupled N $$ \mathcal{N} $$ = 4 super Yang-Mills is described by the large mass limit of a set of thermodynamic Bethe ansatz (TBA) equations. A non-trivial remainder function arises in this setup
Theresa Abl, Martin Sprenger
doaj   +1 more source