Results 91 to 100 of about 208,281 (313)

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, EarlyView.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source

Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase [PDF]

, 2011
The Cockayne Syndrome group B (CSB) protein plays important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair.
Bohr, Vilhelm A., Cheng, Wen-Hsing, Indig, Fred E., Inman, Syed Z., Kufe, Donald William, Saxena, Satya P., Stevnsner, Tinna   +6 more
core   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study

Frontiers in Physiology, 2017
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible
Jaemin Shim, Minki Hwang, Jun-Seop Song, Byounghyun Lim, Tae-Hoon Kim, Boyoung Joung, Sung-Hwan Kim, Yong-Seog Oh, Gi-Byung Nam, Young Keun On, Seil Oh, Young-Hoon Kim, Hui-Nam Pak   +12 more
doaj   +1 more source

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Phytotherapy Research, EarlyView.
ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal, Manjusha Pillai, Md. Shimul Bhuia, Muhammad Torequl Islam, Onkar Sharma, Rachna Verma, Eugenie Nepovimova, Kamil Kuca, Dinesh Kumar, Raihan Chowdhury   +9 more
wiley   +1 more source

Uncovering the Drivers of the Equatorial Ocean Surface Winds

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Wind Patterns along the Equator. Shown are daily mean wind patterns along the equatorial basin indicated in Figure 1a as a meridional mean along −2∘$$ -{2}^{\circ } $$ to +2∘$$ +{2}^{\circ } $$ latitude, land cells included, from a 2‐year ICON simulation. Five ocean basins are shown in black. Yellow boxes outline the seasons and ocean basins, which are
Marius Winkler, Tobias Kölling, Juan Pedro Mellado, Bjorn Stevens   +3 more
wiley   +1 more source

Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2018
Suppressor of cytokine signaling 3 (SOCS3) is involved in Bcr-Abl–induced tumorigenesis. However, how SOCS3 interacts with Bcr-Abl and is regulated by Abl kinases remains largely unknown.
Riyue Feng, Xuefei Wang, Jianning Li, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang, Ji-Long Chen   +8 more
doaj  

The Ablative Case in Vergil [PDF]

The Classical Quarterly, 1921
In the course of a note on Aen. VIII. 86 sq. by Dr. J. W. Mackail (Class. Rev. XXXII. 1918, p. 103), the Servian interpretation of line 96 (‘secant placido aequore siluas’: ostendit adeo perspicuam fuisse natuvam fluminis ut in eo apparerent imagines nemorum, quas Troianae naues secabant) is supported with the observation that 'note should be taken of ...
openaire   +2 more sources

Total energy conservation for explaining discrepancies between field observations and the traditional thermal energy balance

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Motivated by discrepancies between field observations and the traditional thermal energy balance derived from the first law of thermodynamics, total energy conservation is applied to derive a generalized thermal energy balance for atmospheric applications. Total energy conservation accounts for all forms of energy variation, including kinetic, thermal,
Jielun Sun, Joseph Tribbia
wiley   +1 more source

Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway

Molecular Cancer, 2019
Background Long noncoding RNAs (lncRNAs), defined as the transcripts longer than 200 nt without protein-coding capacity, have been found to be aberrantly expressed in diverse human diseases including cancer.
Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang, Ji-Long Chen   +9 more
doaj   +1 more source