Results 141 to 150 of about 208,281 (313)

More Cables to Abl [PDF]

open access: yesNeuron, 2000
Chad A. Cowan, Mark Henkemeyer
openaire   +3 more sources

Insights into the clinical, platelet and genetic landscape of inherited thrombocytopenia with malignancy risk

open access: yesBritish Journal of Haematology, EarlyView.
Inherited thrombocytopenia (IT) caused by germline variants in RUNX1, ETV6 or ANKRD26 carries a high risk of developing haematological malignancy. This study examined the clinical, platelet and molecular characteristics of 66 patients with these conditions, who carried 24 distinct genetic variants in the corresponding genes.
Ana Marín‐Quílez   +34 more
wiley   +1 more source

Abnormal high density lipoproteins of abetalipoproteinemia: relevance to normal HDL metabolism

open access: yesJournal of Lipid Research, 1982
We investigated high density lipoprotein (HDL) subfractions in abetalipoproteinemia (ABL) using rate zonal ultracentrifugation. In ABL, HDL2 is the major subfraction, 65% of total mass compared to less than 10% in normal subjects with similar HDL levels.
R J Deckelbaum   +4 more
doaj  

TP‐0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome‐Derived Cell Line

open access: yesCancer Science, EarlyView.
TP‐0903 exerts the antitumor effects through diverse cell‐specific mechanisms, including apoptosis, ferroptosis, and cell cycle disruption. These insights underline the potential of TP‐0903 as a therapeutic agent for hematological malignancies and emphasize the need for further research to fully elucidate the molecular targets of TP‐0903 and optimize ...
Tomoko Kimura‐Hyoda   +10 more
wiley   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

open access: yesCell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far   +4 more
wiley   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Revisiting the “W” Questions

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Chronic myeloid leukemia (CML) has undergone a transformation from a fatal disease to a chronic, manageable condition with the advent of tyrosine kinase inhibitors (TKIs), particularly imatinib. This shift has significantly improved survival rates, and for some patients, achieving deep molecular response (DMR) has made treatment‐free remission
Antonella Bruzzese   +9 more
wiley   +1 more source

Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes in Escherichia coli

open access: yesMicrobiology Spectrum
Antimicrobial blue light (aBL) is a promising non-antibiotic approach to fighting multidrug-resistant bacteria. However, the complete mechanism of aBL action is not fully understood yet.
Beata Kruszewska-Naczk   +4 more
doaj   +1 more source

BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy [PDF]

open access: bronze, 1994
JQ Guo   +9 more
openalex   +1 more source

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