Results 11 to 20 of about 62,826 (275)
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Cell, 2002 Despite years of investigation, the molecular mechanism responsible for regulation of the c-Abl tyrosine kinase has remained elusive. We now report inhibition of the catalytic activity of purified c-Abl in vitro, demonstrating that regulation is an intrinsic property of the molecule.
Pluk, Helma +2 more
openaire +5 more sources
Plants, 2021 We will study the effects of the methanol extract of Sphagneticola trilobata (L.) Pruski (Asteraceae) (MeST) on the growth of leukemia cells that may contain the BCR/ABL gene. This study also clarifies the mechanism of this effect on these cells.
Hoang Thanh Chi +2 more
doaj +1 more source
To Be Able To, or To Be Able Not To? That is The Question
European journal of analytic philosophy, 2019 A type of transcendental argument for libertarian free will maintains that if acting freely requires the availability of alternative possibilities, and determinism holds, then one is not justified in asserting that there is no free will. More precisely: if an agent A is to be justified in asserting a proposition P (e.g. "there is no free will"), then A
Nadine Elzein, Tuomas K. Pernu
openaire +5 more sources
Linguistica Brunensia, 2018 In the article, I look at two constructions that roughly correspond to the English morpheme -ABLE: the first is a synthetic form based on a verb, in which the root is followed by the suffix TEL and the suffix N, while the other is an analytic form with the verb in the infinitive and a form of the verb GIVE and an impersonal SE. I argue for a particular
openaire +4 more sources
Clinical and Translational Medicine, 2023 Background Abelson tyrosine kinase (c‐Abl) is frequently mutated and highly expressed, and promotes non‐small‐cell lung cancer (NSCLC) survival, metastasis and tumorigenesis.
Yuanming He +9 more
doaj +1 more source
An updated checklist of the lichens of St. Eustatius, Netherlands Antilles
MycoKeys, 2018 In the course of a multi-taxon biodiversity inventory for the island of St. Eustatius, lichens were collected from 11 plots representing different vegetation types.
Andre Aptroot, Michael Stech
doaj +3 more sources
Molecular Cancer, 2022 Background Dysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal translocation between human chromosome 9 and 22, is associated with several hematological malignancies ...
Yun Ma +7 more
doaj +1 more source
Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis
Cell Death and Disease, 2021 Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes ...
Shuoyi Jiang +9 more
doaj +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources