Results 21 to 30 of about 62,826 (275)

BCR-ABL affects STAT5A and STAT5B differentially. [PDF]

PLoS ONE, 2014
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5
Michael Schaller-Schönitz, David Barzan, Andrew J K Williamson, John R Griffiths, Iris Dallmann, Karin Battmer, Arnold Ganser, Anthony D Whetton, Michaela Scherr, Matthias Eder   +9 more
doaj   +1 more source

Treatment and management of advanced heart failure in elderly

Monaldi Archives for Chest Disease, 2019
Heart failure (HF) is a life-limiting condition, associated with high morbidity. End-stage, known as advanced heart failure (AHF), is more common among the elderly.
Nidal Tourkmani
doaj   +1 more source

Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with +8, I(17q)(q10) and der(22)t(9;22) After Imatinib Therapy

Journal of Blood Medicine, 2023
Peng Shan,1,2 Hang Dong,1,2 Shilan Li3 1Department of Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, People’s Republic of China; 2Core Unit ...
Shan P, Dong H, Li S
doaj  

MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Molecular & Cellular Oncology, 2018
MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility – working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton.
Jimok Yoon, Jonathan R. Terman
doaj   +1 more source

Distinct effects of Abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature. [PDF]

PLoS ONE, 2014
Abelson tyrosine kinase (Abl) is known to regulate axon guidance, muscle development, and cell-cell interaction in vivo. The Drosophila primary culture system offers advantages in exploring the cellular mechanisms mediated by Abl with utilizing various ...
Lijuan Liu, Chun-Fang Wu
doaj   +1 more source

Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor microenvironment

Journal for ImmunoTherapy of Cancer
Background TIGIT was identified as a target immune checkpoint for overcoming resistance to PD-(L)1-blocking antibodies. However, the clinical efficacies of TIGIT antibodies were moderate in monotherapy and mixed in combination with PD-(L)1 antibodies.
Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung   +9 more
doaj   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment. [PDF]

PLoS ONE, 2009
BACKGROUND:t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome--Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Claudia Oancea, Reinhard Henschler, Malcolm A S Moore, Martin Ruthardt   +4 more
doaj   +1 more source

Abl Is Able to Inhibit Cell Engulfment

PLoS Biology, 2009
Programmed cell death is essential to development—it's how the tiny mitten of a growing hand becomes a glove of individuated fingers, for instance. To dispose of all those cellular corpses, nearby cells (or roving specialists such as the immune system's macrophages) engulf their dead neighbors and digest the remains.
openaire   +5 more sources

İmatinib: Mechanisms of Action and Mechanisms of Resistance Development

Ankara Üniversitesi Tıp Fakültesi Mecmuas, 2012
İmatinib is a specific drug which was developed for the treatment of chronic myelogenous leukemia (KML) and is the pioneer drug in this area. İmatinib mesylate (Glivec) is a derivative of 2-phenylaminopyrimidine.
M. Merve Tuğlu, Mehmet Melli
doaj   +1 more source

Kill Two Birds with One Stone: A Multifunctional Dual‐Targeting Protein Drug to Overcome Imatinib Resistance in Philadelphia Chromosome‐Positive Leukemia

Advanced Science, 2022
The Bcr/Abl plays a central role in Philadelphia chromosome‐positive (Ph+) leukemia because of the constitutively activated Abl tyrosine kinase and its downstream pathways.
Bohan Ma, Hui Feng, Chao Feng, Yi Liu, Hailing Zhang, Jincheng Wang, Wenjuan Wang, Pengcheng He, Fan Niu   +8 more
doaj   +1 more source