Results 31 to 40 of about 217,258 (295)

Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

Cell Death and Disease, 2021
Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes ...
Shuoyi Jiang, Xiaoge Wang, Yuanming He, Hongbiao Huang, Biyin Cao, Zubin Zhang, Jinbao Liu, Qi Wang, Zhenqian Huang, Xinliang Mao   +9 more
doaj   +1 more source

Treatment and management of advanced heart failure in elderly

Monaldi Archives for Chest Disease, 2019
Heart failure (HF) is a life-limiting condition, associated with high morbidity. End-stage, known as advanced heart failure (AHF), is more common among the elderly.
Nidal Tourkmani
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BCR-ABL affects STAT5A and STAT5B differentially. [PDF]

PLoS ONE, 2014
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5
Michael Schaller-Schönitz, David Barzan, Andrew J K Williamson, John R Griffiths, Iris Dallmann, Karin Battmer, Arnold Ganser, Anthony D Whetton, Michaela Scherr, Matthias Eder   +9 more
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A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core   +1 more source

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl [PDF]

, 1999
Cells from individuals with the recessive cancer-prone disorder ataxia telangiectasia (A-T) are hypersensitive to ionizing radiation (I-R). ATM (mutated in A-T) is a protein kinase whose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase,
Arlinghaus, Ralph, Baltimore, David, Chen, Gang, Cong, Feng, Gasser, Paul J., Goff, Stephen P., Lee, Eva Y.-H. P., Liu, Wei, Park, Min S., Song, Binwei, Sung, Patrick, Trujillo, Kelly, Wu, Yun, Xu, Yang, Yuan, Shyng-Shiou F.   +14 more
core   +1 more source

Asymptotic boundary layer method for unstable trajectories : Semiclassical expansions for individual scar wavefunctions. [PDF]

, 2009
We extend the asymptotic boundary layer (ABL) method, originally developed for stable resonator modes, to the description of individual wave functions localized around unstable periodic orbits.
Schomerus, Henning, Vagov, A., Zalipaev, V.   +2 more
core   +2 more sources

MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Molecular & Cellular Oncology, 2018
MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility – working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton.
Jimok Yoon, Jonathan R. Terman
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Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells [PDF]

, 2008
Imatinib inhibits the kinase activity of Bcr-Abl and is currently the most effective drug for treatment of chronic myeloid leukemia (CML). Imatinib also blocks c-Abl, a physiological tyrosine kinase activated by a variety of stress signals including ...
Aulitzky, W. E., Duyster, J., Fanta, S., Miething, C., Skorta, I., Sonnenberg, M., van der Kuip, H.   +6 more
core   +1 more source

Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor microenvironment

Journal for ImmunoTherapy of Cancer
Background TIGIT was identified as a target immune checkpoint for overcoming resistance to PD-(L)1-blocking antibodies. However, the clinical efficacies of TIGIT antibodies were moderate in monotherapy and mixed in combination with PD-(L)1 antibodies.
Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung   +9 more
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Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with +8, I(17q)(q10) and der(22)t(9;22) After Imatinib Therapy

Journal of Blood Medicine, 2023
Peng Shan,1,2 Hang Dong,1,2 Shilan Li3 1Department of Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, People’s Republic of China; 2Core Unit ...
Shan P, Dong H, Li S
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