Results 41 to 50 of about 208,281 (313)

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Atmospheric boundary layer dynamics from balloon soundings worldwide : CLASS4GL v1.0 [PDF]

, 2019
The coupling between soil, vegetation and atmosphere is thought to be crucial in the development and intensification of weather extremes, especially meteorological droughts, heat waves and severe storms.
Meulenberg, Vicky, Miralles, Diego, Petrova, Irina, Santanello, Joseph A, Teuling, Adriaan J, van Heerwaarden, Chiel C, Vilà-Guerau de Arellano, Jordi, Wouters, Hendrik   +7 more
core   +2 more sources

Determining of atmospheric boundary layer heights and its applications to numerical weather prediction models

暴雨灾害, 2022
The Atmospheric Boundary Layer (ABL) links the free atmosphere and the earth surface (land and ocean), and plays a significant role in the initiation and development of rainfall.
Jin WANG, Qianfeng LIAO, Shen YAN, Yi WANG, Jie XIANG   +4 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Similarity theory and calculation of turbulent fluxes at the surface for the stably stratified atmospheric boundary layers [PDF]

, 2006
In this paper we revise the similarity theory for the stably stratified atmospheric boundary layer (ABL), formulate analytical approximations for the wind velocity and potential temperature profiles over the entire ABL, validate them against large-eddy ...
AS Monin, C Yague, DH Lenschow, FTM Nieuwstadt, Igor N. Esau, IN Esau, KP Wittich, KW Ayotte, M Tjernstrom, RJ Beare, Sergej S. Zilitinkevich, SS Zilitinkevich, SS Zilitinkevich, SS Zilitinkevich, SS Zilitinkevich, SS Zilitinkevich, SS Zilitinkevich, T Uttal, U Högström, Z Sorbjan   +19 more
core   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Targeting the oligomerization of BCR/ABL by membrane permeable competitive peptides inhibits the proliferation of Philadelphia Chromosome positive leukemic cells [PDF]

, 2013
The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The constitutive activation of the ABL-kinase in BCR/ABL cells induces the leukemic phenotype.
Beißert, Tim, Goldblum, Amiram, Mahajna, Jamal, Mian, Afsar Ali, Najajreh, Yousef, Oancea, Claudia, Ottmann, Oliver Gerhard, Ruthardt, Martin, Schüll, Marion   +8 more
core  

Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression [PDF]

, 2014
We have previously identified a tyrosine kinase-independent, guanine nucleotide exchange factor (GEF) activity that is contained within the region of p210 BCR/ABL that distinguishes it from p190 BCR/ABL.
Chen, Ru, Fitzpatrick, Ethan R, Hu, Tinghui, Tala, Ilona, Whitehead, Ian P, Williams, David A   +5 more
core   +1 more source

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia. [PDF]

PLoS Genetics, 2015
The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL alone is unable to eradicate Ph(+) leukemia.
Anahita Rafiei, Afsar Ali Mian, Claudia Döring, Anna Metodieva, Claudia Oancea, Frederic B Thalheimer, Martin Leo Hansmann, Oliver Gerhard Ottmann, Martin Ruthardt   +8 more
doaj   +1 more source