Results 41 to 50 of about 217,258 (295)

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Anderson, Ashley Hamilton, Bhatia, Bin Zhang, Branford, Carsten Müller-Tidow, Chen, Chomel, Chu, Copland, Corbin, Daley, Druker, Druker, Druker, Elaine K. Allan, Felsher, Franck E. Nicolini, G. Vignir Helgason, Gabert, Gorre, Gothert, Graham, Hamilton, Hayette, Holyoake, Hughes, Hurtz, Jiang, Jordan, Jordanides, Jorgensen, Konig, Konig, Konig, Koschmieder, Li, Lombardo, Lugo, Mirle Schemionek, Myssina, Notta, Pellicano, Ravi Bhatia, Samanta, Samanta, Schemionek, Scott, Shachaf, Shah, Sharma, Sharma, Sobrinho-Simoes, Steffen Koschmieder, Svetlana Myssina, Talpaz, Tessa L. Holyoake, Valerie G. Brunton, Wang, Weinstein, Weisberg, White   +61 more
core   +2 more sources

Distinct effects of Abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature. [PDF]

PLoS ONE, 2014
Abelson tyrosine kinase (Abl) is known to regulate axon guidance, muscle development, and cell-cell interaction in vivo. The Drosophila primary culture system offers advantages in exploring the cellular mechanisms mediated by Abl with utilizing various ...
Lijuan Liu, Chun-Fang Wu
doaj   +1 more source

Kill Two Birds with One Stone: A Multifunctional Dual‐Targeting Protein Drug to Overcome Imatinib Resistance in Philadelphia Chromosome‐Positive Leukemia

Advanced Science, 2022
The Bcr/Abl plays a central role in Philadelphia chromosome‐positive (Ph+) leukemia because of the constitutively activated Abl tyrosine kinase and its downstream pathways.
Bohan Ma, Hui Feng, Chao Feng, Yi Liu, Hailing Zhang, Jincheng Wang, Wenjuan Wang, Pengcheng He, Fan Niu   +8 more
doaj   +1 more source

Advances and Limitations of Atmospheric Boundary Layer Observations with GPS Occultation over Southeast Pacific Ocean [PDF]

, 2012
The typical atmospheric boundary layer (ABL) over the southeast (SE) Pacific Ocean is featured with a strong temperature inversion and a sharp moisture gradient across the ABL top.
Ao, C. O., Kursinski, E. R., Mannucci, A. J., Wu, D. L., Xie, F.   +4 more
core   +2 more sources

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

npj Parkinson's Disease
Parkinson’s disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of patients ...
Sungwon An, John J. McInnis, Dongin Kim, Yihang Li, Ozge Tasdemir-Yilmaz, Jinhyung Ahn, Brian C. Mackness, Seung-Hwan Kwon, Julia Maeve Bonner, Miran Yoo, Simon Dujardin, Donghwan Kim, Jinyoung Park, Hyesu Yun, Yi Tang, Laurent Pradier, Sumin Hyeon, Daehae Song, Byungje Sung, Rajaraman Krishnan, Brian Spencer, Robert A. Rissman, Jagdeep K. Sandhu, Arsalan S. Haqqani, Jung-Won Shin, Donghwan B. Kim, Hyeran Lee, Jinwon Jung, Weon-Kyoo You, Alexandra T. Star, Christie E. Delaney, Danica B. Stanimirovic, Sergio Pablo Sardi, Sang Hoon Lee, Can Kayatekin   +34 more
doaj   +1 more source

İmatinib: Mechanisms of Action and Mechanisms of Resistance Development

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2012
İmatinib is a specific drug which was developed for the treatment of chronic myelogenous leukemia (KML) and is the pioneer drug in this area. İmatinib mesylate (Glivec) is a derivative of 2-phenylaminopyrimidine.
M. Merve Tuğlu, Mehmet Melli
doaj   +1 more source

Determining of atmospheric boundary layer heights and its applications to numerical weather prediction models

暴雨灾害, 2022
The Atmospheric Boundary Layer (ABL) links the free atmosphere and the earth surface (land and ocean), and plays a significant role in the initiation and development of rainfall.
Jin WANG, Qianfeng LIAO, Shen YAN, Yi WANG, Jie XIANG   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Expanding the horizons of cancer therapy with next-generation 4-1BB agonists: a review of molecular and clinical strategies to maximize efficacy and ensure safety

mAbs
Driven by the substantial limitations of first generation 4–1BB agonists urelumab and utomilumab, the field has shifted toward engineering next-generation molecules with improved therapeutic windows.
Gihoon You, Jungwoo Choi, Chorong Yang, Sora Kim, JuYeun Jeon, Kyungjin Park, Yangsoon Lee, Sang Hoon Lee   +7 more
doaj   +1 more source

New perspectives on the roles of Abl tyrosine kinase in axon patterning

Fly, 2017
The Abelson tyrosine kinase (Abl) lies at the heart of one of the small set of ubiquitous, conserved signal transduction pathways that do much of the work of development and physiology.
Ramakrishnan Kannan, Edward Giniger
doaj   +1 more source