Results 51 to 60 of about 62,826 (275)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said +10 more
wiley +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.Topography of the outer and inner (black line) domains of the simulation (the blue box indicates the region where the probability density functions for Leaf Area Index and wind, temperature and humidity at 2 m above ground are computed). The most common land cover type is also shown over this region for the 3 models to illustrate the differences in ...
Maria A. Jiménez +8 more
wiley +1 more source
An In-house Method for Molecular Monitoring of BCR-ABL
Turkish Journal of Hematology, 2012 OBJECTIVE: At present in Turkey, centers that are able to give reliable RQ-PCR BCR-ABL results are limited in number. We aimed to describe a cost-effective, in-house method for BCR-ABL quantification and to illustrate an example for RQ-PCR validation ...
Hakkı Ogun Sercan +4 more
doaj +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.The evolution of wind gusts is difficult to observe because gusts are short‐lived phenomena that can originate at higher altitudes. During the Field Experiment on Sub‐mesoscale Spatio‐Temporal Variability in Lindenberg (FESSTVaL), novel ground‐based remote‐sensing methodologies were applied to measure wind with Doppler lidars in order to provide the ...
Julian Steinheuer +2 more
wiley +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.Motivated by discrepancies between field observations and the traditional thermal energy balance derived from the first law of thermodynamics, total energy conservation is applied to derive a generalized thermal energy balance for atmospheric applications. Total energy conservation accounts for all forms of energy variation, including kinetic, thermal,
Jielun Sun, Joseph Tribbia
wiley +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.Marine winds near coastal Antarctica are important for sea‐ice variability and ocean circulation. We test the sensitivity of simulated winds to varying uncertain aspects of the atmospheric model configuration. Winds (each configuration a coloured solid line in the figure) are sensitive to model physics, and notably we find that wind stress over a ...
Thomas Caton Harrison +5 more
wiley +1 more source
Frontiers in Microbiology, 2018 Antimicrobial resistance is a threat to public health that requires our immediate attention. With increasing numbers of microbes that are becoming resistant to routinely used antimicrobials, it is vital that we look to other, non-traditional therapies ...
Leon G. Leanse +5 more
doaj +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.This study explores the life cycle of marine fog using a novel L3$$ {\mathrm{L}}^3 $$ coupling method, which integrates large‐eddy simulation (LES), Lagrangian cloud modeling (LCM), and large‐scale dynamics (LSD). Simulations of two fog episodes observed during the FATIMA campaign revealed key insights into the fog's microphysical and dynamic ...
Anup Barve +4 more
wiley +1 more source
Recent progress on nanotechnologies for enhancing blood‐brain barrier permeability
Smart Molecules, EarlyView.In this review, we summarize innovative strategies for harnessing the power of nanotechnology to enhance blood‐brain barrier permeability, a key challenge for central nervous system (CNS) drug delivery. We overview structural innovation of nanocarriers, improvements in targeting strategies, and nanotechnology‐enhanced brain imaging.
Qibin Liu +4 more
wiley +1 more source