Results 61 to 70 of about 217,258 (295)
Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]
, 2011 OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core +2 more sources
Advanced Science, EarlyView.The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan +9 more
wiley +1 more source
Molecular Therapy: Oncolytics, 2020 Chronic myeloid leukemia (CML) is caused by the Philadelphia (Ph+) chromosome carrying the BCR-ABL oncogene, a constitutively active tyrosine kinase. The discovery of imatinib represents a major success story in the treatment against CML.
Liuya Wei +13 more
doaj +1 more source
New records of lichen genera and species for Colombia
Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, 2022 Dirina paradoxa, Heterocyphelium triseptatum, Julella sublactea, Opegrapha aurantiaca, Peltula steppae, Sarcographina cyclospora and Schistophoron tenue are reported for the first time in Colombia.
Edier Alberto Soto +2 more
doaj +1 more source
Relative Humidity as an Indicator for Cloud Formation over Heterogeneous land surfaces [PDF]
, 2008 The influence of land surface heterogeneity on potential cloud formation is investigated using relative humidity as an indicator. This is done by performing numerical experiments using a large-eddy simulation model (LES).
Heerwaarden, C.C., van +1 more
core +2 more sources
Molecular Pathways: BCR-ABL [PDF]
Clinical Cancer Research, 2012 Abstract Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies.
CILLONI, Daniela, SAGLIO, Giuseppe
openaire +3 more sources
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
wiley +1 more source
Abelson Phosphorylation of CLASP2 Modulates its Association With Microtubules and Actin [PDF]
, 2014 The Abelson (Abl) non-receptor tyrosine kinase regulates the cytoskeleton during multiple stages of neural development, from neurulation, to the articulation of axons and dendrites, to synapse formation and maintenance.
Ballif, Bryan A +8 more
core +1 more source
Advanced Science, EarlyView.This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng +7 more
wiley +1 more source
Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade
Cell Communication and Signaling, 2021 The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis.
Jillian Hattaway Luttman +3 more
doaj +1 more source