Results 61 to 70 of about 62,826 (275)

Hyaluronic Acid‐Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis

Small Science, EarlyView.
Hyaluronic acid‐decorated imatinib‐loaded liposomes are developed to specific target CD44 receptor expressed by interstitial lung fibrosis cells, demonstrating higher uptake than empty liposomes. Based on promising in vitro data, they are administered intratracheally and intraperitoneally in a mouse bleomycin model, assessing their ability to decrease ...
Sara Bozzini, Valeria Bincoletto, Laura Pandolfi, Roberta Fusco, Rosanna Di Paola, Salvatore Cuzzocrea, Ilaria Andreana, Barbara Rolando, Eleonora Bozza, Cecilia Bagnera, Manuela Monti, Barbara Stella, Federica Meloni, Silvia Arpicco   +13 more
wiley   +1 more source

The Development of Indo‐Iranian Voiced Fricatives

Transactions of the Philological Society, Volume 123, Issue 1, Page 97-115, March 2025.
Abstract The development of voiced sibilants is a long‐standing puzzle in Indo‐Iranian historical phonology. In Vedic, all voiced sibilants are lost from the system, but the details of this loss are complex and subject to debate. The most intriguing development concerns the word‐final ‐aḥ to ‐o in sandhi.
Gašper Beguš
wiley   +1 more source

Minority Farmer and Rancher Delinquency and Local Cultural Climate: Evidence from Farm Service Agency's County Office Committees

American Journal of Agricultural Economics, EarlyView.
Abstract Farm delinquency is linked to many negative indicators of farm survival, including increased risk of bankruptcy and farm failure. Minority farmers and ranchers (MFR) have been found to exhibit higher rates of delinquency on U.S. Department of Agriculture (USDA) Farm Service Agency (FSA) loans compared to their non‐Hispanic White male ...
Lawson Connor, Bruce L. Ahrendsen, Charles B. Dodson, Logan Moss   +3 more
wiley   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study

Frontiers in Physiology, 2017
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible
Jaemin Shim, Minki Hwang, Jun-Seop Song, Byounghyun Lim, Tae-Hoon Kim, Boyoung Joung, Sung-Hwan Kim, Yong-Seog Oh, Gi-Byung Nam, Young Keun On, Seil Oh, Young-Hoon Kim, Hui-Nam Pak   +12 more
doaj   +1 more source

Total Neoadjuvant Therapy Versus Conventional Neoadjuvant Therapy for Rectal Cancer: Cost Analysis in a Public Healthcare System

ANZ Journal of Surgery, EarlyView.
Costs of neoadjuvant therapy. ABSTRACT Purpose Total neoadjuvant therapy (TNT) has become the standard of care in locally advanced rectal cancer, but its economic impact is unclear. This study compares the cost of TNT with conventional neoadjuvant therapy (CNT), consisting of either short‐course radiotherapy or long‐course chemoradiotherapy, within a ...
Ishraq Murshed, Sergei Bedrikovetski, Ishmam Murshed, Zachary Bunjo, Tracy Fitzsimmons, Michelle Thomas, Tarik Sammour   +6 more
wiley   +1 more source

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

BMC Cancer, 2012
Background Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Mian Afsar, Metodieva Anna, Badura Susanne, Khateb Mamduh, Ruimi Nili, Najajreh Yousef, Ottmann Oliver, Mahajna Jamal, Ruthardt Martin   +8 more
doaj   +1 more source

Genomic variant profiling in blast‐phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations

British Journal of Haematology, EarlyView.
To identify pathogenic somatic and germline gene variants associated with blast‐phase transformation and cancer predisposition in paediatric chronic myeloid leukaemia (CML), n = 19 patients with blast‐phase paediatric CML were analysed with whole genome and targeted panel sequencing and compared to n = 19 patients with chronic phase paediatric CML.
Yvonne Lisa Behrens, Thea Reinkens, Winfried Hofmann, Amelie Gumann, Alisa Förster, Laura Gaschler, Tabita Ghete, Renate Strasser, Jennifer Espenkötter, Bernd Haermeyer, Michaela Losch, Stephanie Sembill, Zofia Wotschofsky, Stephan von Hörsten, Wolfgang Schuh, Nataliya Di Donato, Meinolf Suttorp, Manuela Krumbholz, Tim Ripperger, Brigitte Schlegelberger, Gudrun Göhring, Markus Metzler, Axel Karow   +22 more
wiley   +1 more source

Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2018
Suppressor of cytokine signaling 3 (SOCS3) is involved in Bcr-Abl–induced tumorigenesis. However, how SOCS3 interacts with Bcr-Abl and is regulated by Abl kinases remains largely unknown.
Riyue Feng, Xuefei Wang, Jianning Li, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang, Ji-Long Chen   +8 more
doaj  

Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is a severe disease occurring mainly in the elderly population. Venetoclax (VEN) combined with azacitidine has changed the paradigm of treatment of AML. Nevertheless, approximately 30% of patients are primary refractory to VEN (VEN‐R), with no current therapeutic option.
Sylvain Garciaz, Camille Montersino, Maxence Bourgoin, Arnaud Jacquel, Rémy Castellano, Arnaud Guille, Max Chaffanet, François Bertucci, Marie‐Anne Hospital, José Adélaïde, Patrick Auberger, Norbert Vey, Yves Collette   +12 more
wiley   +1 more source