Results 91 to 100 of about 1,722,355 (254)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Ocular Abnormal Head Posture: A Literature Review. [PDF]

J Curr Ophthalmol, 2021
Akbari MR, Khorrami-Nejad M, Kangari H, Akbarzadeh Baghban A, Ranjbar Pazouki M.   +4 more
europepmc   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Anterior Transposition of the Inferior Oblique Muscle for Primary Unilateral Superior Oblique Muscle Palsy

Türk Oftalmoloji Dergisi, 2011
Pur po se: To evaluate the efficacy and safety of unilateral anterior transposition of the inferior oblique (ATIO) muscle in patients with unilateral superior oblique palsy (SOP).
Hasan Altınkaynak, Serpil Akar, Dilek Alp, Birsen Gökyiğit, Hüseyin Dundar, Necip Kara, Ömer Faruk Yılmaz   +6 more
doaj   +1 more source

Influence of physiotherapy on forward head posture and related problems – a critical review of literature

Forward head posture (FHP) is frequently observed in both patients and the asymptomatic population. FHP is defined as a position in which the external auditory canal is forward to the plumb line that goes through the shoulder.
Burim Gjinovci, Mario Klasic, Zbigniew Wroński   +2 more
core   +1 more source

Relationship between forward head posture with neck pain and disability

, 2019
Introduction: One of the most common poor postures in the head and neck region is the forward head posture (FHP). It seems that improper posture for a long period of time causes abnormal physiological load on the neck.
Raoofi, Zeinab, Emrani, Anita, Sarrafzadeh, Javad, Ghorbanpour, Arsalan   +3 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Photometric analysis of the relationship between craniovertebral angle and facial profile in children aged 10–12 years

Saudi Dental Journal
Background: Head posture deviation is seen in 52.5 % of children aged 6–15 years. Studies have shown that poor posture habits can impair muscle function during craniofacial growth and development.
Maya Rosita, Sarworini B. Budiardjo, Mochamad Fahlevi Rizal   +2 more
doaj   +1 more source

Temperature‐Modulated MEMS Gas Sensor Array Enabled by Physics‐Informed Deep Learning for Thermal‐Runaway Characteristic Gas Discrimination

Advanced Science, EarlyView.
This work presents a 2 × 2 integrated single‐chip MEMS gas sensor array with temperature modulation and deep learning for discriminating thermal‐runaway characteristic gases. The array generates distinct temperature‐modulated response patterns for four characteristic gases (H2, CO, CH4, and CO2), while a HK‐MoE model is developed to achieve robust ...
Qin Luo, Qi Guo, Rongyue Liu, Yilin Li, Haiping Zhu, Wei Zhang, Zhongren Chen, Zhaojun Liu, Xing Cheng   +8 more
wiley   +1 more source