Results 231 to 240 of about 75,608 (325)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Movements induced by optic flow in relation to HINE. [PDF]

open access: yesSci Rep
Pawlak-Andryszczyk Ż   +2 more
europepmc   +1 more source

A Comparative Study on the Irrigation Suitability of Kerala's Rivers Using Fuzzy AHP and Conventional Methods

open access: yesIrrigation and Drainage, EarlyView.
ABSTRACT Food security in Kerala depends on effective irrigation, but poor‐quality irrigation water poses threats such as salinity, sodicity and reduced soil productivity. Although past assessments have been localised, this study presents the first comprehensive, statewide evaluation of irrigation water suitability across 44 major rivers in Kerala.
Raji Karuna   +2 more
wiley   +1 more source

Identification of a De Novo MAGEL2 Pathogenic Variant in Schaaf–Yang Syndrome and the Importance of Paternal Allele Confirmation

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study reports a de novo MAGEL2 pathogenic variant in a patient with Schaaf–Yang syndrome, confirmed through methylation‐sensitive analysis. Combining genomic sequencing with methylation assays helps accurately determine the parental origin of MAGEL2 mutations.
Youn‐Ji Hong   +7 more
wiley   +1 more source

Head and Cervical Posture in Sagittal Skeletal Malocclusions: Insights from a Systematic Review. [PDF]

open access: yesJ Clin Med
Dipalma G   +10 more
europepmc   +1 more source

Mechanistic trials, therapy and developmental science—An exemplar from early autism care

open access: yesJCPP Advances, EarlyView.
Abstract Background Mechanistic design and analysis in clinical trials remains relatively rare in child mental health and autism, despite the considerable value that it could have in developing therapy practice and in illuminating basic science. Clinical trials themselves continue to have insufficient influence on actual clinical practice in child ...
Jonathan Green
wiley   +1 more source

Case Report: An exploration of the neurodevelopmental phenotype of five patients with 48,XXYY during early childhood years. [PDF]

open access: yesFront Endocrinol (Lausanne)
Olaya M   +8 more
europepmc   +1 more source

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