Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
DAMPAK PEMECAHAN SAHAM TERHADAP PERUBAHAN PENGEMBALIAN SAHAM PADA PERUSAHAAN YANG GO PUBLIK DI BURSA EFEK INDONESIA [PDF]
Policy of stock split is the issuer company's efforts to keep the stock remains in the optimal trading range by increasing the number of shares. An information content test is required to see the reaction of a stock split announcement. This study aims to
Nanang, Kurniawan
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
Explaining the Effective Factors on Short Term Abnormal Rate of Return of New Companies' Stock: In Case of Tehran Stock Exchange [PDF]
In this study the existence of abnormal return and its effective factors were examined. The results show that there is positive short term abnormal return during six month after the acceptance of sampled corporations in exchange.
Mohammad Reza Nikbakht +3 more
doaj
The Impact of Conservation Information on Average Abnormal Return: Time Series Analysis
The aims of this research are to examine the impact of conservation-based information to average abnormal return of firms. The data which used in this research are all of the news regarding corporate action especially conservation-based information that ...
Murwatiningsih +3 more
doaj +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Purpose : The result of this research are expected to provide information to the investors to face the similar event so that investors can make decisions to taking profit in the future.
Hadi Cahyono, Hafiz fitradiansyah`
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
THE HIGH-VOLUME RETURN PREMIUM
The objective of this paper is to investigate the role of trading activity in terms of the information it contains about future return. More precisely, we are interested in the power of trading volume in predicting the direction of future return ...
Widuri Kurniasari
doaj

