A combinatorial CAAR-T cell strategy to eliminate factor VIII inhibitors in preclinical models of hemophilia A [PDF]
iScienceSummary: Chimeric autoantibody receptor T (CAAR-T) cell therapy extends CAR-T technology to target autoreactive immune cells, offering a novel approach for treating autoimmune disorders.
Wenjie Li +7 more
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Chimeric autoantibody receptor T cells for targeted depletion of myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-producing B cells [PDF]
Frontiers in ImmunologyAnti-neutrophil cytoplasmic antibody (ANCA) vasculitides are autoimmune disorders driven by autoantibodies against neutrophil granule proteins, myeloperoxidase (MPO) and proteinase 3, which cause necrotizing small-vessel inflammation with prominent lung ...
Heather M. Sosnoski +9 more
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From CAR-T to CAAR-T: redefining targeting strategies in B-cell malignancies through idiotype-directed cellular therapy [PDF]
Frontiers in ImmunologyChimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of selected hematologic malignancies, particularly relapsed or refractory large B-cell lymphoma, B-cell acute lymphoblastic leukemia, and multiple myeloma. However, currently
Tomasz Buczek +3 more
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Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells [PDF]
Frontiers in ImmunologyIntroductionChimeric antigen receptor (CAR) T cells have recently become an important treatment for hematological cancers by efficiently eliminating B cells.
Abigail Cheever +6 more
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Calcium-mediated actin reset (CaAR) mediates acute cell adaptations
eLife, 2016 Actin has well established functions in cellular morphogenesis. However, it is not well understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in particular when cells have to respond to acute signals.
Pauline Wales +24 more
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Chimeric Autoantibody Receptor- and/or Peptide-MHC-Based CAR Therapies for Targeted Elimination of Antigen-Specific B or T Cells in Hypersensitivity Disorders Such as Allergies and Autoimmune Diseases [PDF]
CellsHypersensitivity reactions are dysregulated and potentially devastating immune responses, characterized by a tendency to become chronic. They target either self-proteins or harmless foreign proteins and are driven by both T and B cells. Although numerous
Isidora Protić-Rosić +4 more
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Zora! Festival and The XIIIth CAAR Biennale Conference, Eatonville-Orlando, Florida [PDF]
Литература двух Америк, 2019 The review outlines the history, the major topics and events of the ZORA! Festival of the Arts and Humanities and the XIIIth CAAR biennale conference which took place on January 26 – February 3, 2019 at the UCF, Orlando and Eatonville.
Irina V. Morozova
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Jurnal Siasat Bisnis, 2021 The purpose of this research is to examine the effect of SRI index on abnormal return of added to and deleted stocks of two countries, Indonesia (SRI-KEHATI) and Malaysia (FTSE4GBM).
Klara Petra Theodora Targanski +1 more
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CAR-T therapy: pioneering a new era in the treatment of autoimmune diseases [PDF]
Frontiers in ImmunologyCAR-T therapy, an innovative immunotherapeutic approach, genetically modifies T cells to express CARs, enabling targeted destruction of specific antigen-expressing cells.
Yuanhao Wu +7 more
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Advance in chimeric antigen receptor T therapy in autoimmune diseases [PDF]
Frontiers in ImmunologyAutoimmune diseases are a group of diseases in which the body’s immune system misrecognizes its own antigens resulting in an abnormal immune response, which can lead to pathological damage to or abnormal functioning of its own tissues. Current treatments
Xiaolan Ji +4 more
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