Results 11 to 20 of about 791 (161)

Chimeric Antigen Receptor T-Cells in Myasthenia Gravis: Advances, Safety Challenges, and Future Directions. [PDF]

Muscle Nerve
ABSTRACT This review examines the emerging application of chimeric antigen receptor (CAR) T‐cell therapy in myasthenia gravis (MG), with emphasis on safety, efficacy signals, and future therapeutic potential in treatment‐refractory disease. A comprehensive literature search was conducted across PubMed, medRxiv, bioRxiv, and Google Scholar for studies ...
Hegelmaier T, Duscha A, Desel C, Stassen S, Krzemien T, Hennemann AK, Pappa V, Haghikia A.   +7 more
europepmc   +2 more sources

Association of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios With Three-Vessel Coronary Artery Disease: A Case-Control Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Coronary artery disease (CAD) is a leading cause of mortality worldwide, with inflammation playing a crucial role in its pathogenesis. The neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) are emerging as potential inflammatory biomarkers for CAD severity. This study investigates the association of
Ayazkhoo L, Sistanizad M, Haji Aghajani M, Sadeghi R, Jafari Z, Taherpour N.   +5 more
europepmc   +2 more sources

Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug. [PDF]

HLA
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Schenk HCM, Gille I, Arana C, Rovira J, Palou E, Diekmann F, Roelen DL, Heemskerk MHM, Heidt S.   +8 more
europepmc   +2 more sources

Engineering chimeric autoantibody receptor T cells for targeted B cell depletion in multiple sclerosis model: An in-vitro study

Heliyon, 2023
Background: Recent evidence suggests that B cells and autoantibodies have a substantial role in the pathogenesis of Multiple sclerosis. T cells could be engineered to express chimeric autoantibody receptors (CAARs), which have an epitope of autoantigens ...
Maryam Sahlolbei, Mohammadreza Azangou-Khyavy, Javad Khanali, Babak Khorsand, Aref Shiralipour, Naser Ahmadbeigi, Zahra Madjd, Hossein Ghanbarian, Alireza Ardjmand, Seyed Mahmoud Hashemi, Jafar Kiani   +10 more
doaj   +1 more source

A rule-based theoretical account of social stories to address the double empathy problem

Frontiers in Psychology, 2023
Social Stories™ (SS) is one of the most popular and researched interventions for autistic children. To date, research that focuses on outcomes has been prioritized over the investigation of the psychological mechanisms that inform the intervention.
Louis John Camilleri, Louis John Camilleri, Katie Maras, Mark Brosnan   +3 more
doaj   +1 more source

Futbolcu Transferlerinin Hisse Senedi Fiyatlarına Etkisi: Stoxx Avrupa Futbol Endeksi Üzerine Bir Analiz

Cumhuriyet Üniversitesi İktisadi ve İdari Bilimler Dergisi, 2022
Bu çalışmada STOXX Avrupa Futbol Endeksinde işlem gören 14 futbol kulübünün transfer (satın alma) duyurularına yatırımcıların (futbol kulüplerinin hisse senedi için) tepkisi analiz edilmiştir.
Binali Selman Eren
doaj   +1 more source

Evaluation of VANET Performance for Anonymous Reporting through Coherent, Automatic Address Resolution (CAAR)

Revista Politécnica, 2016
: Due to the unpredictable trajectory of its moving nodes, a VANET is a demanding communication environment. For such dynamic communication infrastructures, when certain requirements neet to be coped, the performance is a critical parameter.
Luis Felipe Urquiza, Ana Fernanda Rodríguez, Carolina Tripp, Mónica Aguilar   +3 more
doaj   +1 more source

Healing With CAARE: An Oasis of Care in the Changing Landscape of Translational Science [PDF]

North Carolina Medical Journal, 2015
There is increasing interest in understanding the impact of clinical and behavioral interventions in real-world settings. In this commentary, we draw on our experiences as partners in community engagement research to illustrate its effectiveness and practicality to reach and serve marginalized individuals across a spectrum of needs.
Mimi M, Kim, Sharon, Elliott-Bynum
openaire   +2 more sources

The impact of corporate spin-offs on shareholders’ wealth: Empirical evidence from India

Cogent Economics & Finance, 2022
Corporate restructuring is a widely adopted mode of improving efficiency and firm performance and has been studied in different country contexts such as the US, Australia, and Europe.
Deeksha Gupta, Rahul Kumar, Subir Chattopadhyay   +2 more
doaj   +1 more source

Like Angler Fish, CAARs Lure Their Prey [PDF]

Molecular Therapy, 2016
Chimeric antigen receptor (CAR) T cells have revolutionized the field of cancer immunotherapy. Genetically redirected killer CD19-CAR T cells have achieved lasting therapeutic effects in patients with B-cell leukemias.1,2 In a brilliant new twist on this system, Ellebrecht et al., as recently reported in Science,3 have conceived of chimeric autoantigen
openaire   +3 more sources