Results 11 to 20 of about 4,062 (173)

A combinatorial CAAR-T cell strategy to eliminate factor VIII inhibitors in preclinical models of hemophilia A [PDF]

iScience
Summary: Chimeric autoantibody receptor T (CAAR-T) cell therapy extends CAR-T technology to target autoreactive immune cells, offering a novel approach for treating autoimmune disorders.
Wenjie Li, Qirui Yang, Shuping Lai, Rongfang Wei, Lisheng Cai, Xue Zhang, Xin He, Yan Chen   +7 more
doaj   +5 more sources

From CAR-T to CAAR-T: redefining targeting strategies in B-cell malignancies through idiotype-directed cellular therapy [PDF]

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of selected hematologic malignancies, particularly relapsed or refractory large B-cell lymphoma, B-cell acute lymphoblastic leukemia, and multiple myeloma. However, currently
Tomasz Buczek, Tomasz Buczek, Aleksandra Butrym, Aleksandra Butrym   +3 more
doaj   +3 more sources

GPIbα CAAR-T cells function like a Trojan horse to eliminate autoreactive B cells to treat immune thrombocytopenia [PDF]

Haematologica
Breakthrough treatment for refractory and relapsed immune thrombocytopenia (ITP) patients is urgently needed. Autoantibody-mediated platelet clearance and megakaryocyte dysfunction are important pathogenic mediators of ITP.
Jie Zhou, Yanyan Xu, Jinhui Shu, Haojie Jiang, Linlin Huang, Min Xu, Junling Liu, Yu Hu, Heng Mei   +8 more
doaj   +3 more sources

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations [PDF]

eLife, 2016
Actin has well established functions in cellular morphogenesis. However, it is not well understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in particular when cells have to respond to acute signals.
Pauline Wales, Christian E Schuberth, Roland Aufschnaiter, Johannes Fels, Ireth García-Aguilar, Annette Janning, Christopher P Dlugos, Marco Schäfer-Herte, Christoph Klingner, Mike Wälte, Julian Kuhlmann, Ekaterina Menis, Laura Hockaday Kang, Kerstin C Maier, Wenya Hou, Antonella Russo, Henry N Higgs, Hermann Pavenstädt, Thomas Vogl, Johannes Roth, Britta Qualmann, Michael M Kessels, Dietmar E Martin, Bela Mulder, Roland Wedlich-Söldner   +24 more
doaj   +5 more sources

Chimeric autoantibody receptor T cells for targeted depletion of myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-producing B cells [PDF]

Frontiers in Immunology
Anti-neutrophil cytoplasmic antibody (ANCA) vasculitides are autoimmune disorders driven by autoantibodies against neutrophil granule proteins, myeloperoxidase (MPO) and proteinase 3, which cause necrotizing small-vessel inflammation with prominent lung ...
Heather M. Sosnoski, William Aguilar, Shawna K. Brookens, David A. Degaramo, John T. Keane, Hyeon-Gyu S. Lewis, Damodar Gullipalli, Wenchao Song, Avery D. Posey, Avery D. Posey   +9 more
doaj   +2 more sources

Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (CAAR)

Clinical Cardiology, 2017
Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5×. It is an uncommon disease that has been diagnosed with increasing frequency
Mario Bollati, Enrico Cerrato, Ivan Nuñez-Gil   +2 more
exaly   +3 more sources

Aortic arch surgery in real-life practice: is the frozen elephant trunk always a better option than conventional aortic arch replacement? [PDF]

Journal of Cardiothoracic Surgery
Objective Management of aortic arch disease (AAD) is complex due to its involvement in multiple aortic segments and the variety of patient presentations.
Maxime Zimmermann, Matteo Pozzi, Fadi Farhat, Marco Vola, Jean-François Obadia, Antoine Millon, Daniel Grinberg   +6 more
doaj   +2 more sources

Bispecific chimeric autoantibody receptor T cells eliminate acetylcholine receptor-specific B cells in myasthenia gravis models [PDF]

Nature Communications
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder mediated by autoantibodies targeting the nicotinic acetylcholine receptor (nAChR), which can lead to severe disability and life-threatening crises.
Niels von Wardenburg, Gregorio Spagni, S. Momsen Reincke, Stephanie Wernick, Hans-Christian Kornau, Viktoria Zinnow, Amelya Keles Slevogt, Lucie Y. Li, Marie A. Homeyer, Sonja Blumenau, Maria Stecklum, Dietmar Schmitz, Andreas Pelz, Valentina Damato, Nicholas Sanderson, Tobias Derfuss, Minh C. Pham, Kevin C. O’Connor, Andreas Meisel, Harald Prüss   +19 more
doaj   +2 more sources

Rice Leaf Disease Classification—A Comparative Approach Using Convolutional Neural Network (CNN), Cascading Autoencoder with Attention Residual U-Net (CAAR-U-Net), and MobileNet-V2 Architectures

Technologies
Classifying rice leaf diseases in agricultural technology helps to maintain crop health and to ensure a good yield. In this work, deep learning algorithms were, therefore, employed for the identification and classification of rice leaf diseases from ...
Ahmed Al Marouf, Reda Sleiman Alhajj, Jon Rokne   +2 more
exaly   +2 more sources

Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR)

International Journal of Cardiology, 2020
BACKGROUND Coronary Aneurysms are a focal dilatation of an artery segment >1.5-fold the normal size of adjacent segments. Although some series have suggested a prevalence of 0.3-12%, data are lacking.
Isaac Pascual, Fatih Arslan, Maria Del Trigo   +2 more
exaly   +2 more sources