Results 241 to 250 of about 293,712 (302)

Obstructive sleep apnea-hypopnea syndrome induced by dexmedetomidine in a patient with long-term sedatives: A case report. [PDF]

Medicine (Baltimore)
Feng Q, Yin H.
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Acute Pancreatitis Associated With Anaphylactic Shock: A Case Report and Literature Review. [PDF]

Cureus
Leclercq G, Guerisse F.
europepmc   +1 more source

The importance of longitudinal evaluation using DAT-SPECT in organophosphate-induced toxic parkinsonism. [PDF]

PCN Rep
Nakao S, Kogoh Y, Funahashi H, Yanoma Y, Azuma M, Ishida Y, Hirano Y.   +6 more
europepmc   +1 more source

A Flexible Wearable Electronics System for Electrocardiographic Assessment of Colchicine Therapy for Post-MI Remodeling. [PDF]

Sensors (Basel)
Huang W, Gong X, Yang M, Huang T, Zhuang Q, Xiao Z, Xiong T, Yang G.   +7 more
europepmc   +1 more source

Acute Liver Failure Associated With Intravenous Amiodarone: A Case Report. [PDF]

Cureus
Davanellos NI, Giannas R, Kouris NI, Argiropoulos D, Apergis M.   +4 more
europepmc   +1 more source

Rare manifestation of paclitaxel-induced cardiotoxicity: A case of restrictive cardiomyopathy in an elderly breast cancer patient.

Indian J Pharmacol
Masum K, Srinivas S, Ramaiah B.
europepmc   +1 more source