Results 261 to 270 of about 293,712 (302)

Lymphocyte abnormality in human myotonic dystrophy and experimental drug‐induced myotonia

Neurology, 1982
In the cytoplasm of peripheral blood lymphocytes in 3 of 13 patients with myotonic dystrophy, myelin-like structures were observed electronmicroscopically. Some were connected to the cytoplasmic membranes, and some were surrounded by a limiting membrane possessing acid phosphatase activity.
A, Hiraoka, T, Kitani, M, Takahashi, S, Tarui   +3 more
openaire   +2 more sources

Behavioral and electrophysiological abnormalities in two rat models of antiretroviral drug-induced neuropathy

Pain, 2015
Painful peripheral neuropathy due to the antiretroviral therapy used to treat HIV is one of the most prevalent side effects occurring in at least 30% of patients living with this infection. We have evaluated the electrophysiological and behavioral effects of d4T and ddC on peripheral large and small nerve fibers in male rats treated with d4T (Sprague ...
Garcia-Perez, Elizabeth; Sola, Roma; Sumalla, Mireia; Serra, Jordi   +4 more
openaire   +2 more sources

Drug-Induced Abnormalities of Liver Heme Biosynthesis

2020
In the liver most of the heme synthesized by the parenchymal cells is apparently destined for the cytochromes of the P450 group, a family of related but distinct hemoproteins under the control of separate genes. Protoporphyrinogen is then oxidized to protoporphyrin by another oxidase and the last enzyme of heme biosynthesis, ferrochelatase, inserts ...
openaire   +1 more source

Drug Induced ECG Abnormalities

American Journal of Critical Care, 2015
Teri M, Kozik, Mary G, Carey, Salah S, Al-Zaiti, Michele M, Pelter   +3 more
openaire   +2 more sources

Drug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management

Drug Discovery Today, 2022
Menglong Li, Zhining Wen
exaly  

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Chiara Corti   +2 more
exaly  

Serologic abnormalities in spontaneous and drug-induced systemic lupus erythematosus.

The Journal of rheumatology, 1975
Extensive serologic changes occur in systemic lupus erythematosus (SLE) which are probably secondary to unknow primary cause(s). The New Zealand hybrid mouse model most likely has a viral-induced disease and does not show many of the clinical features of the human disease.
openaire   +1 more source

Induced pluripotent stem cells — opportunities for disease modelling and drug discovery

Nature Reviews Drug Discovery, 2011
Berta Strulovici, George Q Daley, Daley George Q   +2 more
exaly  

[Drug-induced abnormal behaviors].

Nihon rinsho. Japanese journal of clinical medicine, 2008
Koichi, Kaneko, Kazuyuki, Nakagome
openaire   +1 more source

Induced protein degradation: an emerging drug discovery paradigm

Nature Reviews Drug Discovery, 2016
Craig M Crews, Crews Craig M
exaly